Virtual screening of Microalgal compounds as potential inhibitors of Type 2 Human Transmembrane serine protease (TMPRSS2) [PDF]
arXiv, 2021 More than 198 million cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported that result in no fewer than 4.2 million deaths globally. The rapid spread of the disease coupled with the lack of specific registered drugs for its treatment pose a great challenge that necessitate the development of therapeutic agents from a ...
arxiv
, 2019 Research and Practice in Thrombosis and Haemostasis, Volume 3, Issue S1, Page 1-891, July 2019.
wiley +1 more source
Soybean Cultivars Affecting Performance of Helicoverpa armigera (Lepidoptera: Noctuidae) [PDF]
, 2011 Non
Bahram Naseri, Yaghoub Fathipour
core +1 more source
A folding inhibitor of the HIV-1 Protease [PDF]
arXiv, 2005 Being the HIV-1 Protease (HIV-1-PR) an essential enzyme in the viral life cycle, its inhibition can control AIDS. The folding of single domain proteins, like each of the monomers forming the HIV-1-PR homodimer, is controlled by local elementary structures (LES, folding units stabilized by strongly interacting, highly conserved, as a rule hydrophobic ...
arxiv
Hispidin and Lepidine E: two Natural Compounds and Folic acid as Potential Inhibitors of 2019-novel coronavirus Main Protease (2019-nCoVMpro), molecular docking and SAR study [PDF]
arXiv, 2020 2019-nCoV is a novel coronavirus was isolated and identified in 2019 in Wuhan, China. On 17th February and according to world health organization, a number of 71 429 confirmed cases worldwide, among them 2162 new cases recorded in the last 24 hours. There is no drug or vaccine for human and animal coronavirus.
arxiv
Macrophage HIF‐2α regulates tumor‐suppressive Spint1 in the tumor microenvironment
Molecular Carcinogenesis, 2019 In solid tumors, tumor‐associated macrophages (TAMs) commonly accumulate within hypoxic areas. Adaptations to such environments evoke transcriptional changes by the hypoxia‐inducible factors (HIFs).
Guangxin Ma +9 more
semanticscholar +1 more source
Powerful proteins from polyp possessing predators [PDF]
, 2021 Cnidarians are soft bodied animals possessing complex venom systems which have evolved to allow for the capture of arthropod and vertebrate prey, as well as to defend themselves against such predators.
Robinson P.J. +5 more
core
Purification and characterization of serine proteinase inhibitors from two South African indigenous plants, Acacia karoo and Acacia schweinfurthii [PDF]
, 2009 Serine proteases are known to perform a wide range of functions essential to life; however there has to be some form of control mechanism in place.
Odei-Addo, Frank
core +3 more sources
Repositioning of 8565 existing drugs for COVID-19 [PDF]
arXiv, 2020 The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected near 5 million people and led to over 0.3 million deaths. Currently, there is no specific anti-SARS-CoV-2 medication. New drug discovery typically takes more than ten years.
arxiv
Old Drugs for Newly Emerging Viral Disease, COVID-19: Bioinformatic Prospective [PDF]
arXiv, 2020 Coronavirus (COVID-19) outbreak in late 2019 and 2020 comprises a serious and more likely a pandemic threat worldwide. Given that the disease has not approved vaccines or drugs up to now, any efforts for drug design and or clinical trails of old drugs based on their mechanism of action are worthy and creditable in such circumstances.
arxiv