Results 51 to 60 of about 3,879 (179)

An epigenetic genome-wide screen identifies SPINT2 as a novel tumor suppressor gene in pediatric medulloblastoma.

Cancer Research, 2008
Medulloblastoma (MB) is a malignant cerebellar tumor that occurs primarily in children. The hepatocyte growth factor (HGF)/MET pathway has an established role in both normal cerebellar development as well as the development and progression of human brain
P. Kongkham, P. Northcott, Y. Ra, Y. Nakahara, T. Mainprize, S. Croul, Christian A. Smith, Michael D. Taylor, J. Rutka   +8 more
semanticscholar   +1 more source

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 92 crystal structures [PDF]

arXiv, 2020
Currently, there is no effective antiviral drugs nor vaccine for coronavirus disease 2019 (COVID-19) caused by acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to its high conservativeness and low similarity with human genes, SARS-CoV-2 main protease (M$^{\text{pro}}$) is one of the most favorable drug targets.
arxiv  

Design of a folding inhibitor of the HIV-1 Protease [PDF]

arXiv, 2004
Being HIV-1-PR an essential enzyme in the viral life cycle, its inhibition can control AIDS. Because the folding of single domain proteins, like HIV-1-PR is controlled by local elementary structures (LES, folding units stabilized by strongly interacting, highly conserved amino acids) which have evolved over myriads of generations to recognize and ...
arxiv  

Drug Repurposing to find Inhibitors of SARS-CoV-2 Main Protease [PDF]

arXiv, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the strain of coronavirus that causes coronavirus disease 2019 (COVID-19), the respiratory illness responsible for the COVID-19 pandemic. Currently there is no known vaccine or specific antiviral treatment for COVID-19 and so, there is an urgent need for expedite discovery of new ...
arxiv  

Up‐regulation of SPINT2/HAI‐2 by Azacytidine in bone marrow mesenchymal stromal cells affects leukemic stem cell survival and adhesion

Journal of Cellular and Molecular Medicine, 2018
The role of tumour microenvironment in neoplasm initiation and malignant evolution has been increasingly recognized. However, the bone marrow mesenchymal stromal cell (BMMSC) contribution to disease progression remains poorly explored.
F. M. Roversi, N. M. Cury, M. Lopes, K. Ferro, J. Machado-Neto, M. Alvarez, Gabriela Pereira Dos Santos, Renata Giardini Rosa, A. L. Longhini, A. Duarte, F. Pericole, P. Favaro, J. A. Yunes, S. Saad   +13 more
semanticscholar   +1 more source

Conformations of Proteins in Equilibrium [PDF]

, 2001
We introduce a simple theoretical approach for an equilibrium study of proteins with known native state structures. We test our approach with results on well-studied globular proteins, Chymotrypsin Inhibitor (2ci2), Barnase and the alpha spectrin SH3 domain and present evidence for a hierarchical onset of order on lowering the temperature with ...
arxiv   +1 more source

Novel in vitro inhibitory functions of potato tuber proteinaceous inhibitors

Zeitschrift für Induktive Abstammungs- und Vererbungslehre, 2014
Plant protease inhibitors are a structurally highly diverse and ubiquitous class of small proteins, which play various roles in plant development and defense against pests and pathogens.
M. Fischer, M. Kuckenberg, Robin Kastilan, J. Muth, C. Gebhardt   +4 more
semanticscholar   +1 more source

Characterization of coffee (coffea sp.) genes induced during coffee leaf miner (leucoptera coffeella) infestation [PDF]

, 2018
Orientador: Marcelo Menossi TeixeiraTese (doutorado) - Universidade Estadual de Campinas, Instituto de BiologiaResumo: O café é um dos principais produtos agrícolas mundiais. O Brasil é um dos maiores países produtores e consumidores de café. Assim sendo,
Mondego, Jorge Mauricio Costa
core  

Brown Spider (Loxosceles genus) Venom Toxins: Tools for Biological Purposes [PDF]

, 2011
Venomous animals use their venoms as tools for defense or predation. These venoms are complex mixtures, mainly enriched of proteic toxins or peptides with several, and different, biological activities.
Amzallag, Ana Carolina M. Wille, Andrade, Andrea Senff-Ribeiro, Appel, Appel, Barbaro, Barbaro, Barbaro, Barbaro, Barbaro, Barla, Barrett, Bazile, Becker-Pauly, Benting, Bheekha-Escura, Binford, Binford, Binford, Binford, Black, Bommer, Bond, Botzki, Burgess, Burgess, Calvete, Cans, Chaim, Chaim, Chang, Chaves-Moreira, Chen, Chen, Choi, Chuang, Corzo, Corzo, Cramer, Cunha, da Silva, da Silveira, da Silveira, da Silveira, da Silveira, Daly, Daniele Chaves-Moreira, de Castro, De Lima, Dias-Lopes, Dilza Trevisan-Silva, Diochot, Domingos, dos Santos, Dragulev, Duarte, Dumermuth, Dunn, Efferth, Escoubas, Escoubas, Escoubas, Etesse, Feitosa, Felicori, Fernandes Pedrosa, Fernandes-Pedrosa, Fernando Hitomi Matsubara, Flight, Flight, Futrell, Gachet, Gao, Girish, Gnanasekar, Gnanasekar, Gomez, Gomez-Cambronero, Gomis-Rüth, Goolsby, Gremski, Grishin, Gross, Gurevitz, Haeberli, He, Heine, Hinojosa-Moya, Hogan, Hsu, Huwiler, Irving, Jung, Kaiser, Kalapothakis, Kang, Kemparaju, Kim, King, Koh, Krowarsch, Krywko, Kuhn-Nentwig, Kusma, Laskowski, Law, Lee, Li, Liu, Lokeshwar, Lu, Luciano, Luiza Helena Gremski, Lung, Ma, MacDonald, MacDonald, Machado, Magalhaes, Majd, Markovic-Housley, Marsh, McDermott, McGlasson, Menzel, Mirshafiey, Misbah, Mitsutake, Mohrlen, Mota, Mouhat, Muchmore, Mulenga, Murakami, Murakami, Nagaraju, Nagaraju, Neurath, Nicholson, Norton, Norton, Oldemir Carlos Mangili, Olga Meiri Chaim, Otlewski, Paixao-Cavalcante, Paludo, Pauli, Pauli, Platnick, Rafael Bertoni da Silveira, Ramos-Cerrillo, Ramu, Ramu, Rao, Rash, Rash, Rash, Reitz, Ribeiro, Rimphanitchayakit, Rocha-e-Silva, Rodrigues, Rohrmann, Roth, Sales, Schmidtko, Schroeder, Senff-Ribeiro, Shafqat, Shafqat, Sharma, Shuster, Silvio Sanches Veiga, Slaby, Sterchi, Stocker, Stocker, Stocker, Su, Sun, Susini, Swanson, Takahashi, Tambourgi, Tambourgi, Tan, Tedford, Telerman, Trevisan-Silva, Tuynder, Tuynder, Valéria Pereira Ferrer, van de Sande, van Meeteren, Veiga, Veiga, Veiga, Vetter, Villanova, Waldemiro Gremski, Weisel-Eichler, Wood, Wright, Wurm, Yamanouye, Yang, Yarm, Yuan, Zanetti, Zhao, Zhou, Zhu, Zobel-Thropp   +213 more
core   +4 more sources

Predicting inhibitors for SARS-CoV-2 RNA-dependent RNA polymerase using machine learning and virtual screening [PDF]

arXiv, 2020
Global coronavirus disease pandemic (COVID-19) caused by newly identified SARS- CoV-2 coronavirus continues to claim the lives of thousands of people worldwide. The unavailability of specific medications to treat COVID-19 has led to drug repositioning efforts using various approaches, including computational analyses.
arxiv