Results 181 to 190 of about 28,023 (246)

Comparison of JB4 plastic resin and standard paraffin methods on student performance and student perspectives in digital histology education: A randomized controlled study

Anatomical Sciences Education, Volume 19, Issue 5, Page 723-731, May 2026.
Abstract This randomized controlled study compared the effectiveness of histological preparations embedded in glycol methacrylate‐based JB4 plastic resin with traditional paraffin blocks in digital histology education. A total of 297 second‐year medical students at Sivas Cumhuriyet University participated.
Zeynep Deniz Şahin İnan, Ezgi Ağadayı   +1 more
wiley   +1 more source

Weighing the Benefits of Improving the Iron Status Against the Risk of Overload—A Narrative Review on Oral Iron Supplementation in Premenopausal Women

BioFactors, Volume 52, Issue 3, May/June 2026.
Iron deficiency is a global phenomenon, particularly prevalent among menstruating females due to dietary factors and uterine bleeding. As first‐line therapy, oral iron therapy effectively improves quality of life but requires consideration of adverse effects. ABSTRACT To this day, women of childbearing age remain the largest group at high risk for iron
Katharina Jans, Patricia Huebbe, Anna P. Kipp, Gerald Rimbach   +3 more
wiley   +1 more source

Impact of Underlying Liver Disease on the Risk and Prognostic Factors of Breast Cancer Liver Metastases: A Retrospective Multicenter Cohort Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Objective To examine factors influencing breast cancer liver metastases (BCLM) and assess the impact of underlying liver diseases (nonalcoholic fatty liver and HBsAg infection) on BCLM development. Methods Patients diagnosed with breast cancer at four affiliated hospitals in China between 2014 and 2024 were included.
Xiaowen Wang, Yuan Zhang, Qiwei Yang, Luo Yang, Yanhui Wang, Xiangxin Zeng, Long Zou, Yujuan Guo, Wenyang Zhou, Yuqi Jiang, Jiezhong Wu, Peng Zhang, Song Zhou, Guangjuan Zheng, Tao Huang, Genshu Wang, Kunpeng Hu   +16 more
wiley   +1 more source

Fibroblast growth factor 10 attenuates advanced liver fibrosis through hepatocyte fibroblast growth factor receptor 2 signalling

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
FGF10‐FGFR2 signaling is progressively impaired during liver fibrosis. FGF10 restoration protects hepatocytes from inflammatory and apoptotic injury. Hepatocyte FGFR2 mediates FGF10‐driven suppression of fibrogenic remodeling through the GSK3β/NF‐κB axis.
Xuanxin Yang, Qingqing Dong, Jiaying Ma, Yawei Yan, Shuangyan Peng, Qiqi Wu, Huan Wang, Tingting Zhang, Panyu Zhang, Zelong Jiang, Chao Lu, Le Li, Xinyi You, Yuandong Xu, Joshua Banda, Zhixiang Mu, Minghua Zheng, Xiaokun Li, Qi Hui, Bingjie Yu, Xiaojie Wang   +20 more
wiley   +1 more source

Melatonin and Quercetin Co‐Treatment Attenuates Hepatic Damage in Diabetic Rats by Mitigating Oxidative Stress and Inflammation

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 5, May 2026.
Quercetin and melatonin, alone or combined, effectively protect the liver in diabetic rats. The antioxidants reduce hyperglycemia, oxidative stress, and inflammation, preventing hepatic damage. ABSTRACT Liver complications in diabetes are very common, contributing to a high mortality rate, making it essential to develop strategies to minimize this ...
Érique Ricardo Alves, Jaiurte Gomes Martins da Silva, Ismaela Maria Ferreira de Melo, Laís Caroline da Silva Santos, Marcelle Mariana Sales de França, Clovis Lapa Neto, Vanessa Bischoff Medina, Francisco de Assis Leite Souza, Leucio Duarte Vieira, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley Teixeira   +10 more
wiley   +1 more source

Ergothioneine Ameliorates Alcoholic Fatty Liver Disease: A Dual Strategy of Accelerated Ethanol Elimination and Reducing Oxidative Stress

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 5, May 2026.
Ergothioneine (EGT) ameliorates alcoholic fatty liver disease via a dual mechanism: accelerating ethanol clearance by protecting ADH/ALDH activity (serum EtOH decreased 54.4%), and reducing oxidative stress/inflammation via antioxidant restoration (GSH‐Px increased 198.2%) and NF‐κB suppression (IL‐1β decreased 67.1%), collectively reversing hepatic ...
Wei Ding, Juan Cao, Cong Guo, Xu Li, Wei Liu, Guohua Xiao   +5 more
wiley   +1 more source

Platelet‐Activating Factor Pathway in Women With Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity

Obesity, Volume 34, Issue 5, Page 1056-1067, May 2026.
Increased hepatic PAFR expression in MASLD is associated with histological disease severity and may contribute to progression through platelet activation, whereas circulating Lp‐PLA2 levels lack discriminatory value as a noninvasive biomarker. ABSTRACT Objective This study aimed to investigate the platelet‐activating factor (PAF) pathway in obesity ...
Joan Duran‐Bertran, Helena Clavero‐Mestres, Razieh Mahmoudian, Sara Muñiz‐Piera, Carmen Aguilar, David Riesco, Javier Camaron, Salomé Martínez, Margarida Vives, Marta París, Fàtima Sabench, Teresa Auguet   +11 more
wiley   +1 more source

Extrahepatic Gene Editing In Vivo Using Organic Solvent‐Free Lipid Nanoparticles

Small, Volume 22, Issue 27, 14 May 2026.
This article highlights a novel, organic solvent‐free lipid nanoparticle (LNP) formulation that avoids cholesterol, thereby reducing hepatic accumulation and immune activation. These BLNPs enable potent, flexible, and scalable gene delivery, supporting personalized medicine and diverse nucleic acid applications.
Michael Streiber, Na Liu, Laurianne Simon, Franziska Adermann, Vivien Bachmann, Lucas Gath, Stephanie Hoeppener, Stephanie Schubert, Oliver Werz, Vincent Lapinte, Marie Morille, Michael Bauer, Adrian T. Press, Ulrich S. Schubert, Anja Traeger   +14 more
wiley   +1 more source

Innovative γ‐Oryzanol and KC2 Based Lipid Nanoparticles: OryKL Platform Provides Safe and Efficient In Vivo mRNA Delivery

Small, Volume 22, Issue 26, 8 May 2026.
Identified through multi‐stage selection process, a formulation combining γ‐oryzanol and DLin‐KC2‐DMA, termed as OryKL, demonstrates unique nano‐structural features, highly efficient mRNA transfection and functional integrity during long‐term storage, enables broad biodistribution and distinct cell tropism following intravenous administration with no ...
Pengkai Shi, Haikun Liu, Ahmed Refaat, Hung Nguyen, Anne Nguyen, Kaiting Miao, Yuyang Song, Sylvain Trépout, Rico F. Tabor, Liliana de Campo, Karlheinz Peter, Mark Louis P. Vidallon, Xiaowei Wang   +12 more
wiley   +1 more source

A Biomimetic Micro‐Nano System Maximizing ‘Active Transport and Retention’ Effect in Solid Tumors

Small, Volume 22, Issue 25, 4 May 2026.
The Active Transport and Retention (ATR) strategy is realized using a biomimetic micro‐nano system (PG@BAM‐LRC), achieving superior tumor accumulation and efficacy in low‐EPR pancreatic tumors. Platelet (PG)‐derived microcarriers enable tumor‐homing and MMP‐9‐responsive release of nanoliposomes (LRC), while berbamine (BAM) promotes transendothelial ...
Kaiyun Yang, Jiajia Su, Alan J. Davidson, Zimei Wu, Wenli Zhang   +4 more
wiley   +1 more source