Results 101 to 110 of about 50,401 (271)

Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions

Drug Delivery, 2018
Because of its multifaceted anti-inflammatory and immunomodulatory effects, delivering type-I interferon to Kupffer cells has the potential to function as a novel type of therapy for the treatment of various types of hepatitis.
Yuki Minayoshi, Hitoshi Maeda, Hiroki Yanagisawa, Keisuke Hamasaki, Yuki Mizuta, Kento Nishida, Ryo Kinoshita, Yuki Enoki, Tadasi Imafuku, Victor Tuan Giam Chuang, Tomoaki Koga, Yukio Fujiwara, Motohiro Takeya, Kayoko Sonoda, Tomohiko Wakayama, Kazuaki Taguchi, Yu Ishima, Tatsuhiro Ishida, Yasuko Iwakiri, Motohiko Tanaka, Yutaka Sasaki, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama   +23 more
doaj   +1 more source

Bidirectional effects of Kupffer cells on hepatocyte proliferation in vitro

, 1991
The control of rat hepatocyte DNA synthesis in vitro by Kupffer cells and transformed perisinusoidal lipocytes, i.e. myofibroblast-like cells was studied.
Meyer, Dieter H., Max G. Bachem, Axel M. Gressner, Bachem, Max G., Gressner, Axel M., Dieter H. Meyer   +5 more
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Antimicrobial properties of Kupffer cells [PDF]

Infection and Immunity, 1988
To characterize the antimicrobial activities of Kupffer cells, I harvested macrophages from livers with a technique involving perfusion with collagenase and DNase. Ninety-nine percent of glass-adherent cells had typical macrophage morphology, 99% were esterase positive, and 60% phagocytosed opsonized zymosan when challenged with four particles per ...
openaire   +2 more sources

Induction of Th1Immune responses following laser ablation in a murine model of colorectal liver metastases

Journal of Translational Medicine, 2011
Background Preliminary experimental studies have suggested that the in situ destruction of tumor tissue by local laser ablation (LA) may also stimulate host immunity against cancer.
Muralidharan Vijayaragavan, Nikfarjam Mehrdad, Malcontenti-Wilson Caterina, Fifis Theodora, Lin Wen, Nguyen Linh, Christophi Christopher   +6 more
doaj   +1 more source

In Vitro Human Liver Model of Nonalcoholic Steatohepatitis by Coculturing Hepatocytes, Endothelial Cells, and Kupffer Cells

, 2019
The liver has a complex and unique microenvironment with multiple cell-cell interactions and internal vascular networks. Although nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease with multiple phases, no proper model ...
Cho, Hyun-Jong, Aly Ung, Nureddin Ashammakhi, Suurmond, Ceri-Anne E., Ali Khademhosseini, Lee, Kang Ju, Khademhosseini, Ali, Junmin Lee, Ashammakhi, Nureddin, Mehmet R. Dokmeci, Soufian Lasli, Han‐Jun Kim, Praveen Bandaru, Kim, Han Jun, van den Dolder, Floor W., Lee, KangJu, Suurmond, Ceri Anne E., Lasli, Soufian, Ahadian, Samad, Hyun‐Jong Cho, Lee, Junmin, Ceri‐Anne E. Suurmond, Bandaru, Praveen, Dokmeci, Mehmet R., Kim, Han-Jun, Floor W. van den Dolder, KangJu Lee, Ung, Aly, Samad Ahadian, Cho, Hyun Jong   +29 more
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PhD

, 2008
dissertationPrevious studies have shown mammalian hepatic adenylate cyclase is stimulated by several compounds including: fluoride ion, guanosine-5-trophosphate (GTP), glucagon, secretin and vasoactive intestinal polypeptide (VIP).
Wincek, Thomas John.
core  

Characterisation of Kupffer cells in some Amphibia

Journal of Anatomy, 2000
A study on the Kupffer cells (KCs) of Amphibia was undertaken in order to compare these cells with those of endothermic animals. Liver tissue and isolated and cultured KCs were studied by light microscopy and by transmission and scanning electron microscopy.
C, Corsaro, M, Scalia, N, Leotta, F, Mondio, G, Sichel   +4 more
openaire   +3 more sources

Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis

Nature Communications
Kupffer cells are liver resident macrophages and play critical role in fatty liver disease, yet the underlying mechanisms remain unclear. Here, we show that activation of G-protein coupled receptor 3 (GPR3) in Kupffer cells stimulates glycolysis and ...
Ting Dong, Guangan Hu, Zhongqi Fan, Huirui Wang, Yinghui Gao, Sisi Wang, Hao Xu, Michael B. Yaffe, Matthew G. Vander Heiden, Guoyue Lv, Jianzhu Chen   +10 more
doaj   +1 more source

Unique protective function of Kupffer cells

, 2017
Kupffer cells The most important function of Kupffer cells is defense against infections and tumor cells. Kupffer cells act as antigen presenting cells and as effector cells that act directly by phagocytosis, or indirectly by activation of other cells, e.
Matoshvili, M.; Tbilisi State Medical University, Dermatology and Venereology, Delibashvili, D., Samkharadze, B., Tophuria, D.; Tbilisi State Medical University Departments: Human Normal Anatomy   +3 more
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Apolipoprotein E is secreted by cultured lipocytes of the rat liver.

Journal of Lipid Research, 1991
Hepatic lipocytes, the retinoid-storing cells of the liver, share several characteristics with vascular smooth muscle cells. To determine whether they also share the characteristic of apolipoprotein E secretion, we have compared the relative mRNA ...
G Friedman, LM Liu, SL Friedman, JK Boyles   +3 more
doaj   +1 more source