Results 81 to 90 of about 74,691 (293)

Amiloride reduces portal hypertension in rat liver cirrhosis [PDF]

, 2010
Objective This study aimed to investigate the effect of amiloride on portal hypertension. Amiloride is known to inhibit Na(+)/H(+) exchangers on activated hepatic stellate cells.
Beitinger, Frigga, Bystron, Markus, De Toni, Enrico N., Gerbes, Alexander L., Hartmann, Anna C., Hennenberg, Martin, Steib, Christian J.   +6 more
core   +1 more source

Laparoscopic Delivery of a MnO2‐P‐ICG Patch for Photodynamic Therapy and NK Cell‐Driven Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study proposes a flexible MnO2‐P‐ICG nanofiber patch for laparoscopic treatment of liver tumors. The patch alleviates tumor hypoxia and induces photodynamic therapy (PDT) triggered immunogenic cell death, thereby activating the cGAS‐STING pathway and, in synergy with pachymaran, promoting NK cell–mediated innate immunity. This synergistic strategy
Jie Lin, Haoqi Pan, Ke Wu, Junjie Nan, Jinyao Dai, Yushun Chang, Hao Shen, Qingxuan Ye, Haowen Lu, Yuxuan Shen, Boqiang Liu, Ming Wu, Jicheng Yu, Xiujun Cai, Dong Cen   +14 more
wiley   +1 more source

Kupffer Cells Sense Free Fatty Acids and Regulate Hepatic Lipid Metabolism in High-Fat Diet and Inflammation

Cells, 2020
A high fat Western-style diet leads to hepatic steatosis that can progress to steatohepatitis and ultimately cirrhosis or liver cancer. The mechanism that leads to the development of steatosis upon nutritional overload is complex and only partially ...
Kira L. Diehl, Julia Vorac, Kristina Hofmann, Philippa Meiser, Iris Unterweger, Lars Kuerschner, Heike Weighardt, Irmgard Förster, Christoph Thiele   +8 more
doaj   +1 more source

A Dynamic 3D Human Liver Sinusoid Model for Mechanistic Interrogation of Fontan‐Associated Liver Disease

Advanced Science, EarlyView.
This study presents a perfusable 3D bioengineered liver sinusoid platform that integrates biofabrication, 3D cell culture, controlled hemodynamics, and multiparametric characterization to model Fontan‐associated liver disease. By decoupling pressure and hypoxia effects, the system reveals early mechanobiological and profibrotic responses under ...
Sarah Rezapourdamanab, Mehdi Salar Amoli, Tanmay Mukherjee, Maryam Bagheri, Boeun Hwang, Linqi Jin, Yamini Singh, Sophia Norton, Ashay Vishwas Bongirwar, Shweta Karnik, Lakshmi Prasad Dasi, Reza Avazmohammadi, Rene Romero, Holly D. Bauser‐Heaton, Vahid Serpooshan   +14 more
wiley   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Effect of Kupffer cells depletion on ABC phenomenon induced by Kupffer cells-targeted liposomes

Asian Journal of Pharmaceutical Sciences, 2019
Accelerated blood clearance (ABC) phenomenon is common in many PEGylated nanocarriers, whose mechanism has not been completely elucidated yet. In this study, the correlation between Kupffer cells (KCs) and ABC phenomenon has been studied by KCs-targeted ...
Chaoyang Lai, Cong Li, Mengyang Liu, Qiujun Qiu, Xiang Luo, Xinrong Liu, Ling Hu, Yihui Deng, Yanzhi Song   +8 more
doaj   +1 more source

Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection

Nature Communications, 2020
Kupffer cells are more resistant to M. tuberculosis when compared with alveolar macrophages. Here the authors show that this distinction is caused by the presence of ornithine and imidazole in Kupffer cells and that these metabolites can drive autophagy ...
Ramya Sivangala Thandi, Rajesh Kumar Radhakrishnan, Deepak Tripathi, Padmaja Paidipally, Abul K. Azad, Larry S. Schlesinger, Buka Samten, Sachin Mulik, Ramakrishna Vankayalapati   +8 more
doaj   +1 more source

A hitchhiker's guide to myeloid cell subsets: practical implementation of a novel mononuclear phagocyte classification system [PDF]

, 2015
The classification of mononuclear phagocytes as either dendritic cells or macrophages has been mainly based on morphology, the expression of surface markers, and assumed functional specialization.
Adams, Ajami, Ajami, Bachem, Bachem, Bain, Bain, Balan, Becker, Benson, Bogunovic, Breton, Caton, Caux, Cheong, Chorro, Chou, Cisse, Contreras, Coombes, Crozat, Crozat, Crozat, Desch, Diao, Durand, Edelson, Epelman, Gao, Gatto, Gautier, Geissmann, Geurtsvankessel, Ghosh, Ginhoux, Ginhoux, Ginhoux, Gomez Perdiguero, Grajales-Reyes, Guilliams, Guilliams, Guilliams, Guilliams, Guilliams, Guilliams, Gurka, Hacker, Hashimoto, Helft, Hettinger, Hildner, Hoeffel, Hoeffel, Inaba, Jackson, Jaitin, Jakubzick, Jang, Janssen, Jha, Karsunky, Kashiwada, Kuipers, Lavin, Lee, Lewis, McKenna, Merad, Miller, Molawi, Murray, Naik, Naik, Naik, Ohl, Onai, Onai, Palucka, Persson, Plantinga, Poltorak, Poulin, Pulendran, Randolph, Reynolds, Robbins, Sallusto, Salomon, Satpathy, Saunders, Schiavoni, Schlitzer, Schlitzer, Schraml, Schulz, Scott, Serbina, Shalek, Siddiqui, Sun, Suzuki, Swirski, Tailor, Tamoutounour, Tamoutounour, Tamura, Tussiwand, van Furth, van Furth, Varol, Varol, Varol, Vu Manh, Vu Manh, Vu Manh, Waskow, Wimmers, Wu, Xu, Xue, Yamasaki, Yona, Yona, Zigmond   +123 more
core   +2 more sources

Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes

Advanced Science, EarlyView.
This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang, Ning Lu, Xin‐Xiu Lin, Xu‐Hui Fang, Yi‐Hui Li, Qing‐Peng Luo, Yu‐Ting Peng, Gil Mor, Ai‐Hua Liao   +8 more
wiley   +1 more source

CLEC4F is an inducible C-type lectin in F4/80-positive cells and is involved in alpha-galactosylceramide presentation in liver. [PDF]

PLoS ONE, 2013
CLEC4F, a member of C-type lectin, was first purified from rat liver extract with high binding affinity to fucose, galactose (Gal), N-acetylgalactosamine (GalNAc), and un-sialylated glucosphingolipids with GalNAc or Gal terminus.
Chih-Ya Yang, Jiun-Bo Chen, Ting-Fen Tsai, Yi-Chen Tsai, Ching-Yen Tsai, Pi-Hui Liang, Tsui-Ling Hsu, Chung-Yi Wu, Mihai G Netea, Chi-Huey Wong, Shie-Liang Hsieh   +10 more
doaj   +1 more source