Results 61 to 70 of about 50,401 (271)

Correlation between Kupffer Cell Infiltration and Liver Parenchymal Cell Damages in Immunosuppressed Drugs-Induced Rats

Majalah Kedokteran Bandung
The liver is the largest organ in the body, composed of both parenchymal and non-parenchymal cells. Chemical substances and various drugs can induce liver injury and involve Kupffer cells which are non-parenchymal cells that release biologically active ...
Agni Febrina Pargaputri, Endah Wahjuningsih, Dwi Andriani   +2 more
doaj   +1 more source

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Arachidonic acid stimulates TNF? production in Kupffer cells via a reactive oxygen species-pERK1/2-Egr1-dependent mechanism

, 2012
Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York; and 2 Department of Medicine III, University Hospital RWTH Aachen, Aachen, GermanyKupffer cells are a key source of mediators of alcohol-induced liver
Cubero, Francisco Javier, Nieto, Natalia, Cubero Palero, Francisco Javier   +2 more
core   +1 more source

One‐Step Preparation of Lanthanide‐Doped Polyurea Multicolor Microspheres for Versatile Fluorescent Applications

Advanced Science, EarlyView.
Lanthanide‐doped polyurea microspheres are prepared via a facile one‐step precipitation polymerization. They exhibit strong hydrogen‐bonding and coordination interactions with excellent properties, including multicolor emission, high quantum yield (75.3%), remarkable stability, redispersibility, and biocompatibility.
Guiyu Zhang, Xiaoxia Yu, Xinhui Wang, Xiang Zheng Kong, Xiangling Gu, Jitao Liu, Shusheng Li, Xiaoli Zhu, Lianbao Cao, Xubao Jiang   +9 more
wiley   +1 more source

Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro [PDF]

, 1993
Since in juvenile rats the liver is the predominant site of erythropoietin (EPO) gene expression, we have used primary cultures of juvenile rat hepatocytes to establish and in vitro system for investigation of oxygen-dependent EPO formation.
Kurtz, Armin, Eckardt, KU, Ratcliffe, P. J., Ratcliffe, Peter, A. Kurtz, C. W. Pugh, Kurtz, A, Eckardt, Kai-Uwe, Pugh, C. W., K. U. Eckardt, Pugh, Christopher, P. J. Ratcliffe   +11 more
core   +1 more source

SLC38A4 promotes Kupffer cell phagocytosis and suppresses tumor liver metastasis

Experimental and Molecular Medicine
Metastasis is the main cause of cancer-related death. The liver is an organ with high metastatic tropism for various malignancies. Hepatic-resident macrophage Kupffer cells are the major non-parenchymal cells in the liver that phagocytize disseminated ...
Jie Li, Yong-Da Liu, Renjie Wang, Xing-Yi Lin, Yi-Qing Zhu, Wan-Peng Lu, Yan-Fang Tang, Xing-Peng Guo, Yu-Han Ai, Ting-Ting Xu, Sen Lin, Mei Huang, Jinghan Wang, Xiao-Ting Zhu, Ji-Hang Yuan   +14 more
doaj   +1 more source

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

Foamy Kupffer cells.

, 2013
CD68 staining of Kupffer cells in liver of Wt-tp (A), Cd36−/−-tp (B) and Msr1−/−-tp (C) mice.
Dieter Lütjohann (186632), Christoph J. Binder (178876), Tim Hendrikx (186627), Kristiaan Wouters (186625), Veerle Bieghs (186620), Ronit Shiri-Sverdlov (186636), Marten H. Hofker (102396), Maria Febbraio (65515), Patrick J. van Gorp (3185088), Marion J. J. Gijbels (169488), Fons Verheyen (325722)   +10 more
core   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells

, 1999
CD14 is a lipopolysaccharide (LPS) receptor distributed largely in macrophages, monocytes, and neutrophils; however, the role of CD14 in activation of Kupffer cells by LPS remains controversial.
Vitor Seabra, Ayako Ikejima, Nobuyuki Enomoto, David A. Brenner, Kenichi Ikejima, Ronald G. Thurman   +5 more
core   +1 more source