Results 51 to 60 of about 74,691 (293)

Inhibition of Kupffer Cell Activity Improves Transplantation of Human Adipose-Derived Stem Cells and Liver Functions

Cell Transplantation, 2013
Numerous approaches to cell transplantation of the hepatic or the extrahepatic origin into liver tissue have been developed; however, the efficiency of cell transplantation remains low and liver functions are not well corrected.
Il-Hwa Hong, Seon-Young Han, Mi-Ran Ki, Young-Mi Moon, Jin-Kyu Park, Sang-Young You, Eun-Mi Lee, Ah-Young Kim, Eun-Joo Lee, Jae-Ho Jeong, Kyung-Sun Kang, Kyu-Shik Jeong D.V.M., Ph.D.   +11 more
doaj   +1 more source

Identification of Plasmodium GAPDH epitopes for generation of antibodies that inhibit malaria infection

Life Science Alliance, 2018
This study reports on the identification of two Plasmodium GAPDH epitope peptides that are responsible for sporozoite–Kupffer cell interaction and act as antigens against malaria infection.
Sung-Jae Cha, Kyle Jarrod McLean, Marcelo Jacobs-Lorena   +2 more
doaj   +1 more source

Heparanase and macrophage interplay in the onset of liver fibrosis [PDF]

, 2017
The heparan sulfate endoglycosidase heparanase (HPSE) is involved in tumor growth, chronic inflammation and fibrosis. Since a role for HPSE in chronic liver disease has not been demonstrated to date, the current study was aimed at investigating the ...
Crescenzi, Marika, Floreani, Annarosa, Masola, Valentina, Onisto, Maurizio, Russo, Francesco Paolo, Secchi, Maria Francesca   +5 more
core   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

A fresh look at augmenter of liver regeneration in rats. [PDF]

, 1999
Augmenter of liver regeneration (ALR) is a hepatotrophic protein originally identified by bioassay in regenerating rat and canine livers following partial hepatectomy and in the hyperplastic livers of weanling rats, but not in resting adult livers.
Abyss, Armendariz-Borunda, Ascoli, Blomquist, Bucher, Bucher, Bucher, Dallman, Dallman, Davies, DeHemptinne, Earp, Evarts, Fausto, Fausto, Fausto, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Gabriel, Gandhi, Gandhi, Geerts, Giorda, Grisham, Hagiya, Hagiya, Harding, Higgins, Hully, Itoh, Koch, LaBrecque, Lambotte, Leffert, Leffert, Makowka, Marchioro, Marchioro, Mars, Masumoto, Mazzaferro, McJunkin, Mead, Meyer, Michalopoulos, Michalopoulos, Naldini, Pause, Rilo, Rubin, Russell, Sakamoto, Sasaki, Schirmacher, Shaw, Siekierka, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Steer, Steiner, Steiner, Subbotin, Teir, Terblanche, Vujanovic, Wang, Wang, Webber, Webber, Yamate, Younger, Zindi   +86 more
core   +1 more source

CD8+ T cell memory is sustained in mice by hepatic stellate cells

Hepatology, EarlyView., 2022
HSC role in memory CD8+ T cell maintenance. Abstract Background and Aims Long‐lasting immunological memory is the ultimate goal of vaccination. Homeostatic maintenance of memory CD8+ cytotoxic T cells (MemCD8TCs) is thought to be mediated by IL‐15/IL‐15R heterodimer (15HD)‐expressing myeloid cells.
Yi‐Ting Chen, Yu‐Chia Su, Yee‐Ern Or, Chin‐Fu Cheng, John T. Kung   +4 more
wiley   +1 more source

Toll-like receptor-mediated signaling cascade as a regulator of the inflammation network during alcoholic liver disease [PDF]

, 2014
Chronic abuse of alcohol leads to various histological abnormalities in the liver. These are conditions collectively known as alcoholic liver disease (ALD). Currently, ALD is considered to be one of the major causes of death worldwide.
Alisi, A., Ceccarelli, S, Nobili, V
core   +1 more source

Divergent Roles of Kupffer Cell TLR2/3 Signaling in Alcoholic Liver Disease and the Protective Role of EGCGSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Toll-like receptor 2 (TLR2) and TLR3 regulate hepatic immunity under pathological conditions, but their functions and potential drug targets in alcoholic liver disease (ALD) remain poorly understood.
Pingping Luo, Fei Wang, Nai-Kei Wong, Yi Lv, Xinxin Li, Mianhuan Li, George L. Tipoe, Kwok-Fai So, Aimin Xu, Shuaiyin Chen, Jia Xiao, Hua Wang   +11 more
doaj   +1 more source

Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver

iScience, 2021
Summary: Nonalcoholic fatty liver disease (NAFLD) is a global health-care problem with limited therapeutic options. To obtain a cellular resolution of pathogenesis, 82,168 single-cell transcriptomes (scRNA-seq) across different NAFLD stages were profiled,
Qi Su, Sun Y. Kim, Funmi Adewale, Ye Zhou, Christina Aldler, Min Ni, Yi Wei, Michael E. Burczynski, Gurinder S. Atwal, Mark W. Sleeman, Andrew J. Murphy, Yurong Xin, Xiping Cheng   +12 more
doaj   +1 more source

Erythropoietin production by fetal mouse liver cells in response to hypoxia and adenylate cyclase stimulation [PDF]

, 1986
This study was done to investigate aspects of control of extrarenal erythropoietin (Ep) production. To this end we studied the effects of three stimuli of renal Ep production in the adult, i.e.
Bauer, Christian, Jelkmann, W., Kurtz, Armin, Malmström, K., Pfuhl, A.   +4 more
core   +1 more source