Results 71 to 80 of about 50,401 (271)
Advanced Science, EarlyView.Task‐adaptive programmable optics enables label‐free virtual staining through optical‐attention‐guided acquisition and reconstruction. By optimizing wavelength, illumination angle, exposure time, and imaging depth, the framework learns task‐relevant optical measurements, generating clinically interpretable virtual stains with improved fidelity, non ...
Tianyue He +13 more
wiley +1 more source
Hepatic Kupffer cells detection.
, 2019 Sections of liver were immunostained with anti-CD68 antibody to detect Kupffer cells in the liver. Panel A, N group; panel B, N+DDE group; panel C, D group; panel D, D+DDE group. Positive cells were evidenced with black arrows.
Vincenzo Migliaccio (6635675) +4 more
core +1 more source
Effect of Kupffer cells depletion on ABC phenomenon induced by Kupffer cells-targeted liposomes
Asian Journal of Pharmaceutical Sciences, 2019 Accelerated blood clearance (ABC) phenomenon is common in many PEGylated nanocarriers, whose mechanism has not been completely elucidated yet. In this study, the correlation between Kupffer cells (KCs) and ABC phenomenon has been studied by KCs-targeted ...
Chaoyang Lai +8 more
doaj +1 more source
Cells, 2020 A high fat Western-style diet leads to hepatic steatosis that can progress to steatohepatitis and ultimately cirrhosis or liver cancer. The mechanism that leads to the development of steatosis upon nutritional overload is complex and only partially ...
Kira L. Diehl +8 more
doaj +1 more source
Advanced Science, EarlyView.Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta +10 more
wiley +1 more source
High-fat diet increase Kupffer cells and decrease NKT cells.
, 2013 Wild-type C57BL/6 mice were fed either normal diet or high-fat diet for 12 or 16 weeks. Kupffer cells were determined by immunohistochemistry staining or isolated through collagen perfusion.
Min Lian (36697) +4 more
core +1 more source
Alcoholic hepatitis: The pivotal role of Kupffer cells. [PDF]
, 2015 Kupffer cells play a central role in the pathogenesis of alcoholic hepatitis (AH). It is believed that alcohol increases the gut permeability that results in raised levels of serum endotoxins containing lipopolysaccharides (LPS). LPS binds to LPS-binding
Hu, Robert W +4 more
core +1 more source
Advances and perspectives in animal models of human hepatitis A virus
Animal Models and Experimental Medicine, EarlyView.Following HAV infection, humans, non‐human primates, and Ifnar1−/− mice develop characteristic manifestations of hepatitis A, including fecal viral shedding, elevated serum ALT levels, and inflammatory cell infiltration in the liver. In contrast, HAV‐infected human liver chimeric mice exhibit fecal viral shedding but do not develop clinical features of
Jian Li +3 more
wiley +1 more source
The interaction of ceruloplasmin with Kupffer cells.
European journal of cell biology, 1990 The binding and uptake of ceruloplasmin was studied with rat liver cells using gold-labeled probes. Ceruloplasmins from either rat or sheep were used, in which different molecular conformations had been induced according to established biochemical criteria.
DINI L +3 more
openaire +4 more sources
Nature Communications, 2020 Kupffer cells are more resistant to M. tuberculosis when compared with alveolar macrophages. Here the authors show that this distinction is caused by the presence of ornithine and imidazole in Kupffer cells and that these metabolites can drive autophagy ...
Ramya Sivangala Thandi +8 more
doaj +1 more source