Results 111 to 120 of about 50,401 (271)
Kupffer Cells in Health and Disease
, 2014 Kupffer cells (KC), the resident macrophages of the liver, represent the largest population of mononuclear phagocytes in the body. Phenotypic, developmental, and functional aspects of these cells in steady state and in different diseases are the focus of this review.
Woltman, Andrea +3 more
openaire +1 more source
Antitumor Immunity Produced by the Liver Kupffer Cells, NK Cells, NKT Cells, and CD8+ CD122+ T Cells
Clinical and Developmental Immunology, 2011 Mouse and human livers contain innate immune leukocytes, NK cells, NKT cells, and macrophage-lineage Kupffer cells. Various bacterial components, including Toll-like receptor (TLR) ligands and an NKT cell ligand (α-galactocylceramide), activate liver ...
Shuhji Seki +3 more
doaj +1 more source
Poly I:C injection elevates the expression of CRACC on Kupffer cells.
, 2013 CRACC expression on alveolar Mϕ, peritoneal Mϕ and Kupffer cells from mice treated with Poly I:C for 18h was analyzed by flow cytometry. Alveolar Mϕ, peritoneal Mϕ and Kupffer cells were identified as F4/80+ cells.
Jun Wang (5906) +6 more
core +1 more source
Scientific ReportsRecombinant adeno-associated viruses (rAAVs) are a platform of choice for gene therapy. However, liver-directed transduction has been hindered by immune responses unpredicted in the pre-clinical models, resulting in therapy failure.
Isabella Ramella Gal +13 more
doaj +1 more source
A Serum lncRNA Signature Determines Oncogenic YAP Activity in Cancer Patients
International Journal of Cancer, EarlyView.Long non‐coding RNAs (lncRNAs) signatures are promising cancer biomarkers, since their dysregulation in tumors is reflected in body fluids. In this study, next‐generation sequencing, bioinformatics, and gene expression data were combined to investigate an lncRNA signature linked specifically to the cancer‐promoting YAP in several cancer types ...
Fabian Rose +24 more
wiley +1 more source
Kupffer cells in high fat diet-induced insulin resistance
, 2011 Kupffer cells are re-emerging as a critical mediator of liver injury. While the role of Kupffer cells in alcoholic liver disease has been well studied, there is a growing appreciation that Kupffer cells are also critical to the development of hepatic ...
american association for the study of the liver: annual meeting - Liver Fibrosis Special Interest Groups Symposium +1 more
core
IL-6 in serum-free cultured hepatocytes and Kupffer Cells.
, 2014 (A) Representative RT-PCR depicting IL-6 from a serum-free rat hepatocyte culture (Heps) at 2 h after attachment (also see Figure 4A) and from fresh Kupffer Cells (KCs) at 15 min after attachment. GAPDH was used as a positive control.
Anne Orr (205891) +12 more
core +1 more source
iMeta, EarlyView.This study presents a cross‐tissue, single‐cell/single‐nucleus transcriptomic atlas spanning from prenatal to postnatal developmental stages in pig, characterizing 83 distinct cell types from 252,033 cells. Through the construction of cross‐tissue transcriptional regulatory networks and pseudotime trajectories, we revealed that organogenesis is driven ...
Rong Zhou +8 more
wiley +1 more source
Targeting kupffer cells with antisense oligonucleotides [PDF]
, 2002 © 2002 Frontiers in Bioscience. All rights reserved.During proinflammatory reactions such as endotoxemia, ischemia-reperfusion and immune reactions, excessive amounts of cytokines and prostanoids are released resulting in liver injury.
Ponnappa, Biddanda C. +1 more
core
Journal of Applied Toxicology, EarlyView.ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima +4 more
wiley +1 more source