Results 131 to 140 of about 45,372 (255)

The Role of Kupffer Cells and Liver Macrophages in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]

Biomedicines
Tsomidis I, Tsakou A, Voumvouraki A, Kouroumalis E.   +3 more
europepmc   +1 more source

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

Cell Proliferation, EarlyView.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu, Shifei Song, Ruilin Wang, Ni An, Jinmei Diao, Yuguo Chen, Juan Liu, Guoyue Lv   +7 more
wiley   +1 more source

Preoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis. [PDF]

Cell Rep Med
Zhang Y, Zhang Y, Shen C, Li J, Wang H, Hamad A, Cao C, El Moheb M, Wang Y, Xia Y, Cummins KC, Beane J, Ejaz A, Huang H, Tsung A, Zhang H.   +15 more
europepmc   +1 more source

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

DTX1-mediated degradation of TUBB3 in Kupffer cells mitigates hepatocellular carcinoma progression by regulating M1/M2 polarization. [PDF]

Commun Biol
Sun J, Sun T, Zhang Y, Liu B, Yin L.
europepmc   +1 more source

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

Alpha-Lipoic Acid Reduces NLRP3/ASC Expression and IL-1β Release in Kupffer Cells and Improves Insulin Signaling in FL83B Hepatocytes Exposed to a Conditioned Medium. [PDF]

Food Sci Nutr
Ko CY, Lo YM, Nguyen TKN, Kao ST, Wu CH, Huang WC, Shen SC.   +6 more
europepmc   +1 more source

Commentary on "Desialylated Platelets Maintain Immune Quiescence through Regulating Kupffer Cells". [PDF]

Research (Wash D C), 2023
Li C, Morrell CN.
europepmc   +1 more source

CD68 and F4/80 Markers Demonstrate Inflammatory Synergism Between Apical Periodontitis and Liver Fibrosis in Wistar Rats

International Endodontic Journal, EarlyView.
ABSTRACT Aim To evaluate CD68 and F4/80 glycoproteins in the worsening of apical periodontitis (AP) and liver fibrosis (LF) in Wistar rats. Methodology Thirty‐two Wistar rats were distributed in the following groups (n = 8): C—control; AP—apical periodontitis; LF—liver fibrosis; APLF—AP and LF.
L. V. Barroti, C. Cantiga‐Silva, M. P. Justo, P. H. C. Oliveira, F. D. Faria, J. Goto, E. Ervolino, G. Sivieri‐Araújo, T. N. Pinheiro, L. T. A. Cintra   +9 more
wiley   +1 more source

Infiltrating macrophages replace Kupffer cells and play diverse roles in severe alcohol-associated hepatitis. [PDF]

Cell Mol Immunol
Wang Y, Guan Y, Feng D, Maccioni L, Parra MA, Peiffer B, Mackowiak B, Kuwabara T, Mori K, Mukoyama M, Bataller R, Sun Z, Gao B.   +12 more
europepmc   +1 more source