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Zwitterionic Mn(III)‐Tetraphenyl Porphyrins: Water‐Soluble MRI Contrast Agents with High Relaxivity

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Mn(III)‐based contrast agents (MBCAs) are promising and potentially safer alternatives to the Gd(III)‐based contrast agents (GBCAs) currently used in MRI. This study reports the synthesis, physicochemical characterization and first in vivo application of novel Mn(III)‐tetraphenylporphyrin chelates, bearing zwitterionic sulfobetaine or N‐oxide groups ...
Darius Ludolfs, Lennart F. V. Spickschen, Stefanie Bredehöft, Verena R. Schulze, Marie Oest, Samila Leon Chaviano, Neus Feliu, Markus Fischer, Marc‐André Fortin, John V. Frangioni, Wolfgang Maison   +10 more
wiley   +1 more source

From LAL-D to MASLD: Insights into the role of LAL and Kupffer cells in liver inflammation and lipid metabolism. [PDF]

Biochim Biophys Acta Mol Cell Biol Lipids
Bradić I, Kuentzel KB, Pirchheim A, Rainer S, Schwarz B, Trauner M, Larsen MR, Vujić N, Kratky D.   +8 more
europepmc   +1 more source

Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance. [PDF]

Hepatology
Gao H, Rocha KCE, Jin Z, Kumar D, Zhang D, Wang K, Das M, Farrell A, Truong T, Tekin Y, Jung HS, Kempf J, Webster NJG, Ying W.   +13 more
europepmc   +1 more source

N-3 Polyunsaturated Fatty Acids Protect against Alcoholic Liver Steatosis by Activating FFA4 in Kupffer Cells. [PDF]

Int J Mol Sci
Kang S, Koh JM, Im DS.
europepmc   +1 more source

Kupffer cells abrogate homing and repopulation of allogeneic hepatic progenitors in injured liver site. [PDF]

Stem Cell Res Ther
Abbas N, You K, Getachew A, Wu F, Hussain M, Huang X, Chen Y, Pan T, Li Y.   +8 more
europepmc   +1 more source

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Amphibia Kupffer cells

Microscopy Research and Technique, 2002
AbstractAmphibia Kupffer cells (i.e., liver resident macrophages) show many common characteristics when compared with Mammalia Kupffer cells: filopodia, microvillous‐like structures, lamellipodia, fuzzy coat, coated vesicles, bristled vacuoles, nonspecific esterase activity, and pinocytotic and phagocytic activity are present both in Amphibia and ...
Marina Scalia
exaly   +3 more sources

Kupffer cells: finding their niche

Nature Reviews Immunology, 2019
Two new studies define the liver-derived signals that promote Kupffer cell development from a common monocyte precursor.
Yvonne Bordon
exaly   +3 more sources

Differentiation and function of Kupffer cells

Medical Electron Microscopy: Official Journal of the Clinical Electron Microscopy Society of Japan, 2004
Kupffer cells are the largest population of tissue macrophages. They are predominantly distributed in the lumen of hepatic sinusoids and exhibit endocytic activity against blood-borne materials entering the liver. Macrophage colony-stimulating factor and other growth factors regulate Kupffer cell differentiation in the fetal and adult period.
Makoto, Naito, Go, Hasegawa, Yusuke, Ebe, Takashi, Yamamoto   +3 more
exaly   +3 more sources

Kupffer Cells in the Liver

Comprehensive Physiology, 2013
Abstract Kupffer cells are a critical component of the mononuclear phagocytic system and are central to both the hepatic and systemic response to pathogens. Kupffer cells are reemerging as critical mediators of both liver injury and repair.
Laura J, Dixon, Mark, Barnes, Hui, Tang, Michele T, Pritchard, Laura E, Nagy   +4 more
openaire   +2 more sources

TNF receptors in Kupffer cells

Journal of Receptors and Signal Transduction, 2011
Somatostatin is a mediator of immune functions and has been used as an antineoplastic agent in animal models and human neoplasias. We have demonstrated that Octreotide inhibits only LPS induced secretion of proinflammatory cytokines including TNFa by Kupffer cells (KC).
Maria, Georgiadou, George, Notas, Costas, Xidakis, Ioannis, Drygiannakis, Ourania, Sfakianaki, Stefanos, Klironomos, Vassilis, Valatas, Elias, Kouroumalis   +7 more
openaire   +2 more sources