Results 231 to 240 of about 245,162 (297)

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, EarlyView.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

Texture and Color Enhancement Imaging for the Kyoto Classification of Gastritis: Evaluation of Visibility and Color Differences. [PDF]

DEN Open
Oki S, Takeda T, Akazawa Y, Ueyama H, Ikeda Y, Arii S, Sai T, Uemura Y, Iwano T, Yamamoto M, Uchida R, Utsunomiya H, Suzuki N, Abe D, Ikeda A, Yatagai N, Matsumoto K, Ueda K, Hojo M, Nojiri S, Nagahara A.   +20 more
europepmc   +1 more source

Belarus and the Kyoto Protocol: opportunities and challenges [PDF]

, 2003
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core  

An ATP‐Mediated Antibiotic β‐Peptide Nanofiber That Kills Multidrug‐Resistant Bacteria via a Multistage Mechanism

Advanced Science, EarlyView.
The 3K‐AP system forms infinite supramolecular fibrils that undergo controlled degradation into shorter fragments upon enzymatic hydrolysis. Multitechnique imaging reveals a stepwise bacteriolytic mechanism involving bacterial entrapment, disassembly into lethal constructs, and associated extracellular vesicle release, highlighting the dynamic ...
Sohini Chakraborty, Kamal el Battioui, Dániel Molnár, Bálint Jezsó, Lejla Daruka, Tasvilla Sonallya, Tünde Juhász, Rita Hirmondó, Imola Cs. Szigyártó, Loránd Románszki, Natália Tőkési, Daniel Pinkas, Eszter Házy, Olivér Pavela, Andrea Bodor, Zoltán Varga, István Mándity, Mihály Kovács, Csaba Pál, Kata Horváti, Judit Tóth, Tamás Beke‐Somfai   +21 more
wiley   +1 more source

Nivolumab with definitive chemoradiotherapy for oesophageal squamous cell carcinoma (NOBEL): a multicentre, single-arm, phase 2 feasibility trial. [PDF]

EClinicalMedicine
Nomura M, Sakanaka K, Shimizu J, Ohashi S, Katada C, Watanabe A, Amanuma Y, Minashi K, Kato K, Kojima T, Nagashima K, Kim I, Tada H, Nakakura A, Muto M.   +14 more
europepmc   +1 more source

Metal‐Supramolecular Drug Delivery System Empowered Meningeal Lymphatic Vessels‐Bridged Intracranial‐Peripheral Dual Immune Modulation for Reversing Glioblastoma Immune Suppression

Advanced Science, EarlyView.
A novel metal‐supramolecular nanoplatform (FLM@VC) enables efficient brain delivery via meningeal lymphatic vessels (MLVs), bypassing the blood‐brain barrier (BBB) through subcutaneous administration. It reprograms tumor‐associated macrophages (TAMs) and remodels the MLVs to promote DC trafficking and CD8+ T cell activation.
Chenxi Zhang, Zhongsheng Xu, Xiaowen Xu, Zening Zhang, Ranran Luo, Pengchen Ren, Yingying Luo, Qiuchi Wu, Xinyu Liu, Guodong Liu, Xiaojing He, Yun Liu   +11 more
wiley   +1 more source

Smartphone based cognitive behavioural therapy for adults with no or minimal depressive symptoms in Japan: an exploratory secondary analysis of RESiLIENT trial. [PDF]

Lancet Reg Health West Pac
Toyomoto R, Tajika A, Luo Y, Sakata M, Akechi T, Nakayama T, Kondo N, Fukuma S, Horikoshi M, Wason JMS, Noma H, Furukawa TA.   +11 more
europepmc   +1 more source

Forecasting Root Rot Disease through Predictive Microbial Functional Profiling

Advanced Science, EarlyView.
Predicting soil‐borne disease moves beyond observation with a framework that elevates microbial functional genes into reliable forecasting biomarkers. By coupling targeted qPCR assays for core stress‐response genes with machine learning, this method detects root rot risks in pre‐symptomatic soils with over 80% accuracy.
Chuan You, Peng Ren, Ying Guan, Kai Gong, Zhen Hua, Wuxian Zhou, Xinlan Mei, Yikui Wang, Xiaofang Wang, Yangchun Xu, Qirong Shen, Zhong Wei   +11 more
wiley   +1 more source

Developmental dynamics of cellular specialization during proanthocyanidin accumulation in persimmon fruit. [PDF]

Plant Physiol
Fujiwara Y, Nishiyama S, Kusumi A, Okamoto-Furuta K, Yamane H, Yonemori K, Tao R.   +6 more
europepmc   +1 more source

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source