Results 91 to 100 of about 334,489 (293)

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Accuracy of Diagnosing Optic Neuritis Using DANTE T1-SPACE Imaging

Eye and Brain
Ayaka Shimada,1,2 Kenji Suda,1 Eri Nakano,1 Miho Tagawa,1 Manabu Miyata,1 Satoshi Kashii,1 Takuya Hinoda,3 Yasutaka Fushimi,3 Kimitoshi Kimura,4 Ryusei Nishigori,4 Sinyeob Ahn,5 John Grinstead,6 Akitaka Tsujikawa1 1Department of Ophthalmology and Visual ...
Shimada A, Suda K, Nakano E, Tagawa M, Miyata M, Kashii S, Hinoda T, Fushimi Y, Kimura K, Nishigori R, Ahn S, Grinstead J, Tsujikawa A   +12 more
doaj  

Effects of Exposure to Mild Hyperbaric Oxygen on DSS-Induced Colonic Inflammation and Diarrhea in Rats

Journal of Inflammation Research, 2019
Ai Takemura,1 Tatsuro Egawa,2 Takuji Tanaka,3 Takashi Kuramoto,4 Tatsuya Hayashi,2 Akihiko Ishihara1 1Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan; 2Laboratory of
Takemura A, Egawa T, Tanaka T, Kuramoto T, Hayashi T, Ishihara A   +5 more
doaj  

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Detection of Glaucoma and Other Vision-Threatening Ocular Diseases in the Population Recruited at Specific Health Checkups in Japan

Clinical Epidemiology, 2020
Masakazu Yamada,1 Yoshimune Hiratsuka,2 Tadashi Nakano,3 Yoshiyuki Kita,1 Tomoyuki Watanabe,3 Hiroshi Tamura,4,5 Ryo Kawasaki,6 Tetsuji Yokoyama,7 Shigeru Takano8 1Department of Ophthalmology, Kyorin University School of Medicine, Mitaka, Japan ...
Yamada M, Hiratsuka Y, Nakano T, Kita Y, Watanabe T, Tamura H, Kawasaki R, Yokoyama T, Takano S   +8 more
doaj  

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Stress Fractures of the First Rib Related to Soft Tennis, Associated with the Tennis Ground Stroke

Open Access Journal of Sports Medicine, 2023
Akio Sakamoto, Shuzo Okudaira, Yuta Onishi, Takashi Noguchi, Shuichi Matsuda The Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, JapanCorrespondence: Akio Sakamoto, The Department of Orthopaedic Surgery, Graduate ...
Sakamoto A, Okudaira S, Onishi Y, Noguchi T, Matsuda S   +4 more
doaj  

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Nutritional and clinical outcomes of chemoradiotherapy for clinical T1N0M0 esophageal carcinoma

Cancer Management and Research, 2019
Katsuyuki Sakanaka,1 Kota Fujii,1 Yuichi Ishida,1 Shin’ichi Miyamoto,2 Takahiro Horimatsu,3 Manabu Muto,3 Takashi Mizowaki11Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan ...
Sakanaka K, Fujii K, Ishida Y, Miyamoto S, Horimatsu T, Muto M, Mizowaki T   +6 more
doaj  

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source