Results 81 to 90 of about 334,489 (293)

The Great Space Weather Event during February 1872 Recorded in East Asia

, 2018
The study of historical great geomagnetic storms is crucial for assessing the possible risks to the technological infrastructure of a modern society, caused by extreme space-weather events.
Ebihara, Yusuke, Giunta, Alessandra S., Hattori, Kentaro, Hayakawa, Hisashi, Hayakawa, Satoshi, Macdonald, Lee T., Mitsuma, Yasuyuki, Shibata, Kazunari, Silverman, Sam M., Toriumi, Shin, Wild, Matthew N., Willis, David M.   +11 more
core   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Behavior management approach for agitated behavior in Japanese patients with dementia: a pilot study

Neuropsychiatric Disease and Treatment, 2012
Junko Sato,1 Shutaro Nakaaki,2 Katsuyoshi Torii,1 Mizuki Oka,2 Atsushi Negi,1 Hiroshi Tatsumi,3 Jin Narumoto,4 Toshi A Furukawa,5 Masaru Mimura21Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical
Sato J, Nakaaki S, Torii K, Oka M, Negi A, Tatsumi H, Narumoto J, Furukawa TA, Mimura M   +8 more
doaj  

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Three Key Elements of Post-2012 International Climate Policy Architecture [PDF]

We describe three essential elements of an effective post-2012 international global climate policy architecture: a means to ensure that key industrialized and developing nations are involved in differentiated but meaningful ways; an emphasis on an ...
Olmstead, Sheila M., Stavins, Robert N.
core   +3 more sources

Nakajo–Nishimura syndrome and related proteasome-associated autoinflammatory syndromes

Journal of Inflammation Research, 2019
Koichiro Ohmura Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, JapanCorrespondence: Koichiro OhmuraDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of ...
Ohmura K
doaj  

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

Discovery of the First Low-Luminosity Quasar at z > 7

, 2019
We report the discovery of a quasar at z = 7.07, which was selected from the deep multi-band imaging data collected by the Hyper Suprime-Cam (HSC) Subaru Strategic Program survey.
Akiyama, Masayuki, Asami, Naoko, Bosch, James, Furusawa, Hisanori, Goto, Tomotsugu, Gunn, James E., Harikane, Yuichi, Ikeda, Hiroyuki, Imanishi, Masatoshi, Iwasawa, Kazushi, Izumi, Takuma, Kashikawa, Nobunari, Kato, Nanako, Kawaguchi, Toshihiro, Kikuta, Satoshi, Kohno, Kotaro, Komiyama, Yutaka, Koyama, Shuhei, Lee, Chien-Hsiu, Lupton, Robert H., Matsuoka, Yoshiki, Minezaki, Takeo, Miyazaki, Satoshi, Murayama, Hitoshi, Nagao, Tohru, Niida, Mana, Nishizawa, Atsushi J., Noboriguchi, Akatoki, Oguri, Masamune, Ono, Yoshiaki, Onoue, Masafusa, Ouchi, Masami, Price, Paul A., Sameshima, Hiroaki, Schulze, Andreas, Shirakata, Hikari, Silverman, John D., Strauss, Michael A., Sugiyama, Naoshi, Tait, Philip J., Takada, Masahiro, Takata, Tadafumi, Tanaka, Masayuki, Tang, Ji-Jia, Toba, Yoshiki, Utsumi, Yousuke, Wang, Shiang-Yu, Yamashita, Takuji   +47 more
core   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Twist-3 Effects in Polarized Photon Structure

, 2002
The polarized photon structure is described by two spin structure functions $g_1^\gamma$ and $g_2^\gamma$ which can be studied in the future polarized ep or e$^+$e$^-$ colliders.
HIDESHI BABA, KEN SASAKI, TSUNEO UEMATSU, Wandzura S.   +3 more
core   +1 more source