Results 41 to 50 of about 1,121,852 (198)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Current Prevalence of Tuberculous Lesions among Slaughtered Cattle in Northeastern States of Nigeria

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2009
An abattoir study on the prevalence of bovine tuberculosis in six cattle-producing states of Nigeria was carried out from 2000 to 2004. Out of 302,700 slaughtered head of cattle examined postmortem, 4.05% (CI: 3.12, 4.98) had tuberculosis lesions.
M. M. Aliyu, J. Y. Adamu, Y. A. Bilyaminu   +2 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Corrélation IMC lésion méniscale chez les adolescents avec rupture de LCA

La Revue Marocaine de Chirurgie Orthopédique et Traumatologique (RMACOT)
La rupture du LCA chez l’enfant est une lésion grave qui expose le genou aux lésions méniscales puis secondairement à moyen terme à l’arthrose, leur incidence augmente constamment depuis les années 90 avec la pratique toujours croissante des activités ...
Yassine El Qadiri, Yassir El Andaloussi, Abdelouahd Soleh , V. Lethai, M. Raad, M. Brax, Mustapha Fadili   +6 more
doaj   +1 more source

Premiers cas authentiques de farcin du boeuf en Afrique Occidentale Française

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1958
Aucun résumé disponible en français.
Georges Mémery, P. Mornet, A. Camara
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Corrélation IRM-ARTHROSCOPIE dans le diagnostic des lésions méniscales et ligamentaires du genou

La Revue Marocaine de Chirurgie Orthopédique et Traumatologique (RMACOT)
Dans le cadre de l’évaluation du niveau de corrélation entre les résultats de l’IRM des lésions méniscales et ligamentaires à ceux de l’arthroscopie, nous rapportons une série comportant 100 cas des patients présentant une suspicion clinique de lésion ...
Abdessalam Achkoun, Rachid Chafik, Mohamed Madhar, Hanane El Haoury   +3 more
doaj   +3 more sources