Results 111 to 120 of about 4,706 (212)

Treatment and prevention of HIV/AIDS: Unfinished business. [PDF]

PLoS Med
Fauci AS, Folkers GK.
europepmc   +1 more source

Increasing Efficiency of Detection and Validation of Baleen Whale Call Presence on Large Acoustic Datasets: A Case Study Using Sei Whale Downsweeps Recorded in Atlantic Canada

Marine Mammal Science, Volume 42, Issue 2, April 2026.
ABSTRACT As passive acoustic monitoring (PAM) datasets expand, studies increasingly use automated detectors to analyze baleen whale presence. However, detector errors like false positives (impacting precision, P; proportion of detected calls that are correct), and false negatives (impacting recall, R; proportion of available calls successfully detected)
Gabrielle F. Macklin, Hilary B. Moors‐Murphy, Marty L. Leonard   +2 more
wiley   +1 more source

Head‐to‐head comparison of TKI and CPI first‐line treatment strategies in advanced renal cell carcinoma—Real‐world data from the German research platform CARAT

International Journal of Cancer, Volume 158, Issue 6, Page 1690-1702, 15 March 2026.
What's new? The current standard of care for locally advanced or metastatic renal cell carcinoma (aRCC) is either a combination of two immune checkpoint inhibitors (CPI) or a CPI plus a tyrosine kinase inhibitor (TKI). Here, the authors simulate a head‐to‐head trial comparing the real‐world effectiveness of these combination therapies with TKI ...
Peter J. Goebell, Martin Bögemann, Arnd Nusch, Viktor Grünwald, Lothar Müller, Eyck von der Heyde, Uwe M. Martens, Carolin Lennartz, Michaela Koska, Karin Potthoff, Anja Kaiser‐Osterhues, Carsten Grüllich, Michael Staehler, Martina Jänicke, Dominik Marschner, the CARAT Registry Group   +15 more
wiley   +1 more source

Excited State Opto‐Ionic Reservoir Computing in Hybrid Perovskite Electrochemically‐Gated Luminescent Cells

Advanced Materials, Volume 38, Issue 14, 6 March 2026.
A neuromorphic computing system exploiting opto‐ionic modulation in lead halide perovskite microcrystals demonstrates high‐dimensional reservoir dynamics with diffraction‐limited node resolution. Leveraging ultrafast excited‐state interactions, it achieves efficient computation (800 pJ/node‐operation), robustly distinguishing 4‐bit pulse sequences ...
Philipp Kollenz, Carina Herrle, Leonard Göhringer, Nasrin Solhtalab, Tom Wickenhäuser, Wolfram Pernice, Rüdiger Klingeler, Felix Deschler   +7 more
wiley   +1 more source

Clinical Characteristics of Patients With Advanced Hepatocellular Carcinoma Who Transitioned to Subsequent Therapies Following Systemic Therapy. [PDF]

Cancer Med
Imai K, Takai K, Aiba M, Unome S, Miwa T, Hanai T, Sakai H, Shirakami Y, Suetsugu A, Shimizu M.   +9 more
europepmc   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, Volume 13, Issue 17, 23 March 2026.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Dual‐Targeted Type‐I‐Photosensitizer‐Incorporated Covalent Organic Frameworks Overcome Hypoxia Barriers in Hepatocellular Carcinoma for Precision Therapy

Aggregate, Volume 7, Issue 3, March 2026.
A precise dual‐targeting covalent organic framework (COF) nanoplatform that avoids aggregation‐caused quenching (ACQ) to achieve synergistic high‐efficiency Type I photodynamic therapy and chemotherapy. ABSTRACT There is an urgent need to develop innovative therapeutic strategies for hepatocellular carcinoma (HCC) treatment with severe hypoxia ...
Xiang Wang, Hengrui Li, Yihan Ma, Le Wang, Miao Qin, Rui Lou, Jian Yin, Wenbo Ming, Yong Mao, Jing Hu   +9 more
wiley   +1 more source

Clinical Recommendation for the Use of Injectable Lenacapavir as HIV Preexposure Prophylaxis - United States, 2025. [PDF]

MMWR Morb Mortal Wkly Rep
Patel RR, Hoover KW, Lale A, Cabrales J, Byrd KM, Kourtis AP.   +5 more
europepmc   +1 more source

Growth Standards for Children With Smith–Magenis Syndrome (SMS)

American Journal of Medical Genetics Part A, Volume 200, Issue 3, Page 569-578, March 2026.
ABSTRACT Smith–Magenis syndrome (SMS, OMIM 182290) is a complex syndromic diagnosis marked by neurobehavioral differences and distinct facial dysmorphisms, caused by haploinsufficiency of the retinoic acid‐1 (RAI1) gene either by a pathogenic sequence variant or deletion at chromosome 17p11.2 involving a portion or all of this gene.
Julie Hoover‐Fong, John McGready, Leah Fleming, Kerry Schulze, Folami Duncan, Alexis Leonard, Marie Christine de Blois Boucard, Danilo Moretti‐Ferreira, Andrea L. Gropman, Wendy J. Introne, Ann C. M. Smith   +10 more
wiley   +1 more source

Design and Evaluation of Next-Generation HIV Genotyping for Detection of Resistance Mutations to 28 Antiretroviral Drugs Across 5 Major Classes Including Lenacapavir. [PDF]

Clin Infect Dis
Park SY, Takayama C, Ryu J, Sattah M, Badii Z, Kim JW, Shafer RW, Gorbach PM, Lee HY.   +8 more
europepmc   +1 more source