Results 111 to 120 of about 234,030 (235)

Integrated Single‐Cell and Spatial Transcriptomics Reveal Convergence on a Senescence‐Associated B Cell–MIF Signaling Axis in Joint Aging and Osteoarthritis Progression

Advanced Science, EarlyView.
Single‐cell and spatial transcriptomics implicate senescent B cells and macrophage migration inhibitory factor (MIF) signaling in aging and osteoarthritic joints. An injectable hydrogel combining quercetin with siRNA targeting MIF attenuates cartilage degeneration in a mouse model of osteoarthritis.
Weida Li, Yi Wang, Yongqing You, Yue Cui, Jiayun Liu, Xingbiao Ma, QiuYu Zhu, Qiang Wu, Zanjing Zhai, Zuyan Lu, Kerong Dai, Ye Sun   +11 more
wiley   +1 more source

CKMT1 Counteracts VDAC1 Oligomerization‐Induced Neuronal Pyroptosis Through Steric Hindrance in Ischemic Stroke

Advanced Science, EarlyView.
CKMT1 inhibits VDAC1 oligomerization via a dual‐region mechanism: its NTD interacts with the VDAC1 C‐terminal domain, while residues 1–39 sterically hinder dimerization, thereby reducing mtDNA leakage and AIM2 inflammasome activation, suppressing neuronal pyroptosis and protecting against cerebral ischemic injury. ABSTRACT Ischemic stroke is one of the
Xiaoyu Wang, Sai Shi, Jianghui Wu, Jingge Zhang, Shuqin Li, Yuyan Hu, Haifeng Yin, Chenguang Zhao, Dong Ma, Xiaohui Xian, Lizhe Liu, Ling Zhao, Xiyun Liu, Zhikai Yu, Lihua Dong, Wenbin Li, Lingyan Zhang, Min Zhang   +17 more
wiley   +1 more source

Exome Sequencing Uncovers Phenotypic and Genotypic Heterogeneity in 196 Indian Families Evaluated for Autoinflammatory Disorders

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autoinflammatory disorders (AIDs) are a clinically heterogeneous group of inborn errors of immunity primarily caused by dysregulation in the innate immune system. Clinical diagnosis is often challenging due to clinical heterogeneity and the overlapping phenotypes with other inborn errors of immunity and monogenic conditions that mimic AIDs ...
Vaishnavi Ashok Badiger, Periyasamy Radhakrishnan, Suma Balan, Anand P. Rao, Prajna Udupa, Karthik Vijay Nair, Bhagesh Hunakunti, Adarsh Pooradan Prasannakumar, Sanket Limaye, Huzail Gani Shaikh, Rohit Naik, Mahesh Janarthanan, Sudharshan Sridharan, Vishal Sondhi, Sheela Nampoothiri, Hitesh Shah, Sabrinath Mahadevan, Mahabaleshwar Mamadapur, Devang Pandya, Katta Mohan Girisha, Abhay Shivpuri, Amita Moirangthem, Jyothi Raghuram, Gandham Sri Lakshmi Bhavani, Sachin Jeevanagi, Girish Subramaniam, Amita Aggarwal, Anju Shukla, Dhanya Lakshmi Narayanan   +28 more
wiley   +1 more source

Endotoxaemia in childhood-onset systemic lupus erythematosus induces low-density granulocytes and extracellular traps of innate immune cells

Lupus Science and Medicine
Background Endotoxaemia without infection in lupus is mentioned with the inconclusive clinical importance.Methods With endotoxaemia and lupus activity (Systemic Lupus Erythematosus Disease Activity Index 2000 score), 46 patients with childhood-onset ...
Kent Doi, Pornpimol Rianthavorn, Asada Leelahavanichkul, Wilasinee Saisorn, Pornpimol Phuengmaung, Chanunya Santiworakul   +5 more
doaj   +1 more source

Lúpus Eritematoso Sistêmico [PDF]

, 2019
O sistema imunológico defende o organismo de possíveis invasores que possam ser maléficos à saúde, como patógenos infecciosos (vírus, bactérias, fungos, protozoários e helmintos) ocasionando infecções, doenças e processos alérgicos.
Beganovic, Sabina, Dos Santos, Luiza Caroline, Dos Santos, Nathalye Caroline, Ribeiro, Camila Nunes De Morais, Cavani, Victória, Navarro, Stephanie Dynczuki, Galvão, Kethelin, Ribas, João Luiz Coelho   +7 more
core  

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

Segmental composition and nerve distribution of the brachial plexus in Galictis cuja

The Anatomical Record, EarlyView.
Abstract Galictis cuja is a neotropical mustelid with terrestrial locomotor habits, yet the anatomy of its brachial plexus has remained undescribed. This study characterizes the origin, organization, and distribution of the brachial plexus nerves in 15 adult specimens (30 antimeres).
Natan da Cruz de Carvalho, Thais Mattos Estruc, Ingrid Bete Palmeira, Julia Fagundes Franco, Emillin Reis Bermudez, Paulo de Souza‐Junior, Marcelo Abidu‐Figueiredo   +6 more
wiley   +1 more source

Fascicle measurement methods do result in lengths that are significantly different

The Anatomical Record, EarlyView.
A recent comparison of the most prevalent methods for measuring fascicles, in situ measurement versus chemical digestion, concluded that the measurements are indistinguishable based on data from different conspecific individuals. However, our study of contralateral muscles of the same individuals shows that the methods clearly result in statistically ...
Katherine M. Clark, Reece A. Brown, Maggie Funderburk, Elise S. Bush, Anthony Herrel, Adam Hartstone‐Rose   +5 more
wiley   +1 more source

EP-073 - LÚPUS INDUZIDO POR ANTITUBERCULOSTÁTICOS - RELATO DE CASO

Brazilian Journal of Infectious Diseases
Introdução: Queixas articulares de diversas etiologias podem ocorrer no contexto da tuberculose (TB). A infecção pelo bacilo, na sua forma extrapulmonar, pode causar artrite crônica, geralmente mono ou oligoarticular, com inflamação sinovial ...
Glauco Igor Viana Santos, Haroldo de Lucena Bezerra, Giulia Viana Santos   +2 more
doaj   +1 more source

Body mass and sex estimation from lower carnassial tooth morphometry in the endangered Iberian wolf (Canis lupus signatus): An ecomorphological analysis of sexual size dimorphism

The Anatomical Record, EarlyView.
Abstract The Iberian wolf (Canis lupus signatus) is an endangered subspecies characterized by highly fragmented populations and increasing human–carnivore conflict across the Iberian Peninsula. Although body mass strongly influences predator–prey dynamics and ecological performance, quantitative assessments of sexual size dimorphism (SSD) and body mass
Leonardo Cotts, Eduardo Rossener, Ricardo Moratelli, Maria da Luz Mathias, Oscar Rocha‐Barbosa   +4 more
wiley   +1 more source