Results 1 to 10 of about 409 (115)

Homoarginine and creatine deficiency do not exacerbate murine ischaemic heart failure. [PDF]

ESC Heart Fail, 2023
Abstract Aims Low levels of homoarginine and creatine are associated with heart failure severity in humans, but it is unclear to what extent they contribute to pathophysiology. Both are synthesized via L‐arginine:glycine amidinotransferase (AGAT), such that AGAT−/− mice have a combined creatine and homoarginine deficiency.
McAndrew DJ, Lake HA, Zervou S, Schwedhelm E, Schneider JE, Neubauer S, Lygate CA.   +6 more
europepmc   +4 more sources

Homoarginine- and Creatine-Dependent Gene Regulation in Murine Brains with l-Arginine:Glycine Amidinotransferase Deficiency [PDF]

International Journal of Molecular Sciences, 2020
l-arginine:glycine amidinotransferase (AGAT) and its metabolites homoarginine (hArg) and creatine have been linked to stroke pathology in both human and mouse studies.
Marit Jensen, Edzard Schwedhelm, Priyadharshini Arunachalam   +2 more
exaly   +3 more sources

Expression of cardiovascular-related microRNAs is altered in L-arginine:glycine amidinotransferase deficient mice. [PDF]

Sci Rep, 2022
In humans and mice, L-arginine:glycine amidinotransferase (AGAT) and its metabolites homoarginine (hArg) and creatine have been linked to cardiovascular disease (CVD), specifically myocardial infarction (MI) and heart failure (HF).
Jensen M, Müller C, Hübner N, Patone G, Saar K, Choe CU, Schwedhelm E, Zeller T.   +7 more
europepmc   +2 more sources

Arginine:Glycine Amidinotransferase Is Essential for Creatine Supply in Mice During Chronic Hypoxia [PDF]

Frontiers in Physiology, 2021
Juliane Hannemann, Kathrin Cordts, Chi-Un Choe   +2 more
exaly   +2 more sources

Influence of homoarginine on creatine accumulation and biosynthesis in the mouse. [PDF]

Front Nutr, 2022
Organisms obtain creatine from their diet or by de novo synthesis via AGAT (L-arginine:glycine amidinotransferase) and GAMT (Guanidinoacetate N-methyltrasferase) in kidney and liver, respectively.
Lygate CA, Lake HA, McAndrew DJ, Neubauer S, Zervou S.   +4 more
europepmc   +2 more sources

Cardiomyocytes from Creatine-Deficient Mice Lacking L-Arginine:Glycine Amidinotransferase (AGAT) Show No Changes in Mitochondrial Organization and Cellular Compartmentation [PDF]

Biophysical Journal, 2013
In cardiac muscle, the creatine kinase (CK) system temporally buffers ADP and ATP concentrations near sites of ATP production and consumption. It has also been suggested to be an important spatial buffer facilitating the transport of ADP and ATP. This was corroborated by a study of CK knockout mice.
Kotlyarova, S, Mandel, M, Sokolova, N, Aksentijevic, D, Lygate, C, Neubauer, S, Vendelin, M, Birkedal, R   +7 more
openaire   +2 more sources

Creatine Deficiency Disorders: Phenotypes, Genotypes, Diagnosis, and Treatment Outcomes. [PDF]

Turk Arch Pediatr, 2023
Mulik C, Mercimek-Andrews S.
europepmc   +1 more source

Determination of equilibria constants of arginine:glycine amidinotransferase (AGAT)-catalyzed reactions using concentrations of circulating amino acids. [PDF]

Amino Acids, 2023
Tsikas D.
europepmc   +1 more source

Creatine Transporter Deficiency Presenting as Failure to Thrive: A Case Report of a Novel SLC6A8 Variant Causing a Treatable but Likely Underdiagnosed Genetic Disorder. [PDF]

J Investig Med High Impact Case Rep, 2023
Tise CG, Palma MJ, Cusmano-Ozog KP, Matalon DR.   +3 more
europepmc   +1 more source

Guanidinoacetate N-methyltransferase deficiency: Case report and brief review of the literature. [PDF]

Radiol Case Rep, 2023
Libell JL, Lakhani DA, Balar AB, Khan M, Carpenter JS, Joseph JT.   +5 more
europepmc   +1 more source