Results 21 to 30 of about 409 (115)

Oral L-Arg and D-Arg decreased arginine:glycine amidinotransferase protein expression in the liver, but L-Arg increased it in the kidney.

, 2023
Nine-week-old male Sprague-Dawley rats were treated with L-arginine (L-Arg) or D-arginine (D-Arg) at a dose of 1000 mg/kg/d each in drinking water for 16 wks. The control (Con) group received plain drinking water.
Kaushik Desai (314675), Dain (Raina) Kim (16726470), Sarah Martin (1295031)   +2 more
core   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

British Journal of Pharmacology, Volume 178, Issue S1, Page S313-S411, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Doris Koesling, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Michael Russwurm, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +32 more
wiley   +1 more source

Targeted urine metabolomics with a graphical reporting tool for rapid diagnosis of inborn errors of metabolism

Journal of Inherited Metabolic Disease, Volume 44, Issue 5, Page 1113-1123, September 2021., 2021
Abstract The current diagnostic work‐up of inborn errors of metabolism (IEM) is rapidly moving toward integrative analytical approaches. We aimed to develop an innovative, targeted urine metabolomics (TUM) screening procedure to accelerate the diagnosis of patients with IEM.
Laura K.M. Steinbusch, Ping Wang, Huub W.A.H. Waterval, Fons A.P.M. Stassen, Karlien L.M. Coene, Udo F.H. Engelke, Daphna D.J. Habets, Jörgen Bierau, Irene M.L.W. Körver‐Keularts   +8 more
wiley   +1 more source

Plasma creatine and incident type 2 diabetes in a general population‐based cohort: The PREVEND study

Clinical Endocrinology, Volume 94, Issue 4, Page 563-574, April 2021., 2021
Abstract Background Type 2 diabetes is associated with both impaired insulin action at target tissues and impaired insulin secretion in pancreatic beta cells. Mitochondrial dysfunction may play a role in both insulin resistance and impaired insulin secretion. Plasma creatine has been proposed as a potential marker for mitochondrial dysfunction.
Adrian Post, Dion Groothof, Joëlle C. Schutten, Jose L. Flores‐Guerrero, J. Casper Swarte, Rianne M. Douwes, Ido P. Kema, Rudolf A. de Boer, Erwin Garcia, Marge A. Connelly, Theo Wallimann, Robin P. F. Dullaart, Casper F. M. Franssen, Stephan J. L. Bakker   +13 more
wiley   +1 more source

Homoarginine ameliorates diabetic nephropathy independent of nitric oxide synthase‐3

Physiological Reports, Volume 9, Issue 5, March 2021., 2021
Our results indicate that homoarginine mediates renal and cardiac protection in diabetic NOS3‐/‐ mice which will ultimately change our understanding of the mechanism(s) by which homoarginine ameliorate diabetic kidney injury. Homoarginine protective effect in diabetic nephropathy could be mediated via improving mitochondrial function. Abstract Recently
Michael D. Wetzel, Kristen Stanley, Soumya Maity, Muniswamy Madesh, Jean C. Bopassa, Alaa S. Awad   +5 more
wiley   +1 more source

L-arginine:glycine amidinotransferase deficiency protects from metabolic syndrome

, 2013
Item does not contain fulltextPhosphorylated creatine (Cr) serves as an energy buffer for ATP replenishment in organs with highly fluctuating energy demand.
Heerschap, A., Hermans-Borgmeyer, I., Isbrandt, D., Choe, C.U., Nabuurs, C., Marescau, B., Nunes, P.M., Stockebrand, M.C., Hermans Borgmeyer, I., Nunes, P., Morellini, F., Schillemeit, S., Nabuurs, C.I.H.C., Choe, C. U., Neu, A., Sauter, K.   +15 more
core   +2 more sources

Pilot Study on Acute Effects of Pharmacological Intraperitoneal L-Homoarginine on Homeostasis of Lysine and Other Amino Acids in a Rat Model of Isoprenaline-Induced Takotsubo Cardiomyopathy. [PDF]

Int J Mol Sci, 2022
L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys ↔ hArg + Orn; equilibrium constant K(hArg).
Tsikas D, Redfors B.
europepmc   +2 more sources

Image_1_Arginine:Glycine Amidinotransferase Is Essential for Creatine Supply in Mice During Chronic Hypoxia.JPEG

, 2021
Objective: Chronic hypoxia induces pulmonary and cardiovascular pathologies, including pulmonary hypertension (PH). L-arginine:glycine amidinotransferase (AGAT) is essential for homoarginine (hArg) and guanidinoacetate synthesis, the latter being ...
Lena Schmidt-Hutten (11288214), Anika Seniuk (11288211), Chi-un Choe (221251), Kathrin Cordts (11288208), Edzard Schwedhelm (301435), Florian Weinberger (337009), Jorge Duque Escobar (11288217), Juliane Hannemann (23632), Rainer Böger (9423777)   +8 more
core   +1 more source

Image_2_Arginine:Glycine Amidinotransferase Is Essential for Creatine Supply in Mice During Chronic Hypoxia.JPEG

, 2021
Objective: Chronic hypoxia induces pulmonary and cardiovascular pathologies, including pulmonary hypertension (PH). L-arginine:glycine amidinotransferase (AGAT) is essential for homoarginine (hArg) and guanidinoacetate synthesis, the latter being ...
Lena Schmidt-Hutten (11288214), Anika Seniuk (11288211), Chi-un Choe (221251), Kathrin Cordts (11288208), Edzard Schwedhelm (301435), Florian Weinberger (337009), Jorge Duque Escobar (11288217), Juliane Hannemann (23632), Rainer Böger (9423777)   +8 more
core   +1 more source

Homoarginine Levels are Regulated by L-Arginine:Glycine Amidinotransferase and Affect Stroke Outcome: Results from Human and Murine Studies

, 2013
Item does not contain fulltextEndogenous arginine homologues, including homoarginine, have been identified as novel biomarkers for cardiovascular disease and outcomes.
Heerschap, A., Wild, P.S., Gerloff, C., Muller, C., Nabuurs, C., Marescau, B., Boger, R.H., De Deyn, P.P., Grant, P.J., M\"uller, C., Stockebrand, M., Streichert, T., Choe, C. U., Lackner, K., Deyn, P.P. de, Atzler, D., Magnus, T., Carter, A.M., Blankenberg, S., Ojeda, F., Zeller, T., Isbrandt, D., Choe, C.-U., Simova, O., Benndorf, R.A., Schwedhelm, E., L\"uneburg, N., B\"oger, R.H., Luneburg, N., Baldus, S.   +29 more
core   +2 more sources