Results 201 to 210 of about 14,587,455 (250)

Unraveling the Role of the Multifunctional Groups in the Adsorption of l-Cysteine on Rutile TiO₂(110). [PDF]

J Am Chem Soc
Blanco Garcia M, Perilli D, Daldossi C, Ugolotti A, Giordano M, Dolling DS, Wagstaffe M, Kohantorabi M, Stierle A, Di Valentin C, Noei H.   +10 more
europepmc   +1 more source

Zinc Fingers as Programmable Metalloprotein Scaffolds for Altering Pathogenic Biomolecular Phase Transitions

Advanced Science, EarlyView.
Modular zinc finger (ZF) metalloproteins function as programmable biomolecular scaffolds that modulate pathogenic amyloid assembly. Through direct protein–protein interactions, ZF arrays alter amyloid phase behavior and redirect β‐sheet fibrillization toward nontoxic aggregates.
Seongmin Park, Yunha Hwang, Jimin Kwak, Yuxi Lin, Hye‐Yeon Park, Eunju Nam, Jiyeon Han, Soyeon Park, Hyunyong Kim, Ju‐Eun Kim, Hyun Goo Kang, Jiyong Park, Young‐Ho Lee, Kyoung‐Shim Kim, Chul‐Ho Lee, Seung Jae Lee, Mi Hee Lim   +16 more
wiley   +1 more source

From Surface Energetics to Environmental Functionality: Mechanistic Insights into Hg(II) Removal by L-Cysteine-Modified Silica Gel. [PDF]

Gels
Moran-Salazar RG, Manríquez-González R, Peregrina-Lucano AA, Gutierréz-Ortega JA, Lara A, Orozco-Guareño E, Macias-Lamas AM, Badillo-Camacho J, Shenderovich IG, Vazquez-Lepe M, Gómez-Salazar S.   +10 more
europepmc   +1 more source

Epigenetic Silencing of CYYR1 Promotes Lung Adenocarcinoma Progression Through TRIM21‐Dependent Regulation of HMMR Stability

Advanced Science, EarlyView.
CYYR1 as an epigenetically dysregulated tumor‐suppressive factor that influences oncoprotein stability through TRIM21‐dependent HMMR regulation and reveals a potential therapeutic vulnerability in CYYR1‐deficient LUAD. The graphical illustration was created using FigDraw (www.figdraw.com).
Fengsheng Dai, Jingyi Tang, Huan Rong, Yu Wang, Xiangyi Zhou, Can Xu, Jianhua Wang, Lili Li, Yue Wu, Fei Deng, Dan Yang, Xiao Yang, Renyan Li, Yongzhong Wu, Dongxi Xiang, Tingxiu Xiang   +15 more
wiley   +1 more source

A Plasma-Functionalized ECM Platform for Intraoral Inflammation Control: Comparative Effects of Hyaluronic Acid and N-Acetyl-L-Cysteine on Oral Keratinocyte Response. [PDF]

Polymers (Basel)
Muñoz-González PU, Chevallier P, Desparois L, Avon SL, Chandad F, Mantovani D, Houde VP.   +6 more
europepmc   +1 more source

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source

Early ADME and Preliminary Toxicity Studies of I-152, an <i>N</i>-Acetyl-l-Cysteine/<i>S</i>-Acetylcysteamine Conjugate. [PDF]

Chem Res Toxicol
Bartoccini F, Valeri A, Gregori M, Masini S, Bruschi M, Goracci L, Fraternale A, Piersanti G.   +7 more
europepmc   +1 more source

Functional MXene Inks for Printed Electronics: Chemistry, Rheology, and Devices

Advanced Science, EarlyView.
Functional MXene inks are emerging as building blocks for MXetronics, connecting MXene synthesis, surface functionalization, ink formulation, and advanced printing with device‐level applications. This review maps how composition, stability, rheology, and processability govern printed structures and enable high‐performance sensors, energy‐storage ...
Shahzaib Ali, Faisal Shahzad, Hamza Hussain, Muhammad Abbas, Dae‐Hyun Cho, Doyoung Byun, Hassan A. Arafat   +6 more
wiley   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

L-Cysteine-Catalysed Hydration of Activated Alkynes. [PDF]

Angew Chem Int Ed Engl
González-Rodríguez J, González-Granda S, Lavandera I, Gotor-Fernández V, Mangas-Sánchez J.   +4 more
europepmc   +1 more source