Results 51 to 60 of about 14,587,455 (250)
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Augmentation of Human and Rat Lenticular Glutathione in Vitro by Prodrugs of γ-l-Glutamyl-l-cysteine
, 2016 A marked age-related decrease in glutathione (GSH) levels as well as depression of γ-glutamylcysteine synthetase activity are factors that are believed to render the aged lens more susceptible to oxidative stress and, therefore, to cataractogenesis ...
Ann M. Holleschau (3017697) +3 more
core +1 more source
Some Derivatives of L-Cysteine Aldehyde. An Improved Preparation of S-Benzyl-N-phthaloyl-L-cysteine. Amino Acids XXXI [PDF]
, 1955 A method for the preparation of S-benzyl-N-phthaloyl-L-cysteine with [a]D -167° is described. According to the previously described procedure for the preparation of racemic S-benzyl-N-phthaloyl-cysteine aldehyd , the optically active compound was ...
Bregant, N. +4 more
core +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
, 2019 We have reported previously that L-cysteine-derived hydrogen sulfide (H2S) demonstrates a remarkable neuroprotective effect against hypoxia-ischemic (HI) insult in neonatal animals.
Zhen Wang (72451) +9 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2016 Complex-formation reactions of the l-cysteine-derived ligands αN-acetyl-S-methylene-(2‘-pyridine)-l-cysteine (py-CH2-accys) and αN-acetyl-S-ethylene-2-(2‘-pyridine)-l-cysteine (py-C2H4-accys) with [Pt(en)(H2O)2]2+ and [Pd(en)(H2O)2]2+ were investigated ...
Ralf Alsfasser (2711911) +3 more
core +1 more source
Sensors, 2017 A flow-electrolytic cell that consists of a bare gold wire or of different thiol-compound-modified gold electrodes (such as 2,4-thiazolidinedione, 2-mercapto-5-thiazoline, 2-mercaptothiazoline, l-cysteine, thioglycolic acid) was designed to be used in a ...
Lai-Hao Wang, Yu-Han Zhang
doaj +1 more source