Results 61 to 70 of about 457,288 (287)

Anthelmintic action of plant cysteine proteinases against the rodent stomach nematode, Protospirura muricola, in vitro and in vivo [PDF]

, 2007
Cysteine proteinases from the fruit and latex of plants, including papaya, pineapple and fig, were previously shown to have a rapid detrimental effect, in vitro, against the rodent gastrointestinal nematodes, H eligmosomoides polygyrus (which is found in
Behnke, J.M., Buttle, D.J., Duce, I.R., Lowe, A.E., Stepek, G.   +4 more
core   +3 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Development and validation of a stability indicating green analytical method for the simultaneous estimation of l-glutathione, n-acetyl l-cysteine and Vitamin C in marketed formulation using UV–visible spectroscopy

Future Journal of Pharmaceutical Sciences, 2023
Background An efficient ultraviolet spectrophotometric method has been devised for the simultaneous analysis of l-glutathione, n-acetyl l-cysteine and Vitamin C in combined tablet dosage forms.
Himanshu Chaudhry, Naresh Kumar Rangra
doaj   +1 more source

Formulation studies for eliminating saliva carcinogenic acetaldehyde with L-cysteine containing chewing gum [PDF]

, 2012
Tobacco smoke is a major risk factor for the development of cancers in the upper parts of gastrointestinal tract. It has been estimated that the risk of oral cancer among smokers is 7 10 times higher than for never-smokers.
Kartal-Hodzic, Alma
core  

Iterative focused screening with biological fingerprints identifies selective Asc-1 inhibitors distinct from traditional high throughput screening [PDF]

, 2017
N-methyl-d-aspartate receptors (NMDARs) mediate glutamatergic signaling that is critical to cognitive processes in the central nervous system, and NMDAR hypofunction is thought to contribute to cognitive impairment observed in both schizophrenia and ...
Amoss, Adam, Cassaday, Jason A., Cooke, Andrew J., Culberson, J. Chris, Finley, Michael, Hermes, Jeffrey D., Hurzy, Danielle, Johnson, Eric N., Kutchukian, Peter S., Magliaro, Brian C., O’Donnell, Gregory, Parmentier-Batteur, Sophie, Pascarella, Danette, Schlegel, Kelly-Ann Sondra, Squadroni, Brian, Thomson, Fiona, Uebele, Victor N., Warren, Lee, Zuck, Paul   +18 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

On the selection and design of proteins and peptide derivatives for the production of photoluminescent, red-emitting gold quantum clusters [PDF]

, 2013
Novel pathways of the synthesis of photoluminescent gold quantum clusters (AuQCs) using biomolecules as reactants provide biocompatible products for biological imaging techniques.
A Baksi, A Harriman, A Retnakumari, AM Smith, BĐ Glišić, BĐ Glišić, C Giulivi, CAJ Lin, CAJ Lin, CF Shaw III, CL Liu, CV Durgadas, D Toroz, DM Chevrier, F Wen, G Mező, GA Simms, GS Harms, H Kawasaki, H Kawasaki, H Schmidbaur, H Tsunoyama, H Wei, J Xie, J Xie, JS Mohanty, K Chaudhari, L Shang, L Shang, M Zhu, MAH Muhammed, MAH Muhammed, MS Devadas, PK Xavier, PL Xavier, R Hamouda, S Link, S Si, TH Chen, X Wen, X Yuan, X Yuan, XL Guével, Y Negishi, Y Shichibu, Y Shichibu, Y Wang, YH Lin, YN Tan   +48 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Electrochemical Oxidation of l-selenomethionine and Se-methylseleno-l-cysteine at a Thiol-Compound-Modified Gold Electrode: Its Application in a Flow-Through Voltammetric Sensor

Sensors, 2017
A flow-electrolytic cell that consists of a bare gold wire or of different thiol-compound-modified gold electrodes (such as 2,4-thiazolidinedione, 2-mercapto-5-thiazoline, 2-mercaptothiazoline, l-cysteine, thioglycolic acid) was designed to be used in a ...
Lai-Hao Wang, Yu-Han Zhang
doaj   +1 more source