Results 11 to 20 of about 13,238,937 (304)
Crop Journal, 2018 Faba bean (Vicia faba L.) has been identified as a rich source of l-DOPA, which is used in treating Parkinson's disease. Biosynthesis and accumulation of active substances such as l-DOPA in plant tissues may interact with growing conditions and ...
Masoud Hashemi +2 more
exaly +3 more sources
L-Dopa and Schizophrenia [PDF]
Canadian Psychiatric Association Journal, 1976 Previous reports have emphasized the deterioration of schizophrenic patients when given L-Dopa. The authors described a patient with long-standing catatonic schizophrenia who was not helped by conventional therapies but initially responded dramatically to L-Dopa.
P E, Garfinkel, H C, Stancer
openaire +3 more sources
L-Dopa-modified microtubules lead to synapse instability in cultured neurons: possible implications in Parkinson’s disease therapy [PDF]
npj Parkinson's DiseaseL-Dopa, the main Parkinson’s disease treatment, unexpectedly alters the postsynaptic architecture of cultured mouse neurons through its incorporation into α-tubulin via tubulin tyrosine ligase (TTL).
Agustina Zorgniotti +8 more
doaj +2 more sources
L-DOPA functions as a plant pheromone for belowground anti-herbivory communication [PDF]
, 2023 While mechanisms of plant–plant communication for alerting neighbouring plants of an imminent insect herbivore attack have been described aboveground via the production of volatile organic compounds (VOCs), we are yet to decipher the specific components ...
Pickett, J. A. +20 more
core +1 more source
Pyrylium based derivatization imaging mass spectrometer revealed the localization of L-DOPA.
PLoS ONE, 2022 Simultaneous imaging of l-dihydroxyphenylalanine (l-DOPA), dopamine (DA) and norepinephrine (NE) in the catecholamine metabolic pathway is particularly useful because l-DOPA is a neurophysiologically important metabolic intermediate.
Shu Taira +6 more
doaj +1 more source
Bangladesh Journal of Pharmacology, 2023 This study aimed to investigate the effects of levodopa (L-dopa), p-coumaric acid, and combinations in the neuroblastoma (N1E-115) cell. L-dopa and L-dopa plus p-coumaric acid group caused oxidative stress by increasing 12.5 and 3.7-fold in superoxide ...
Nebiye Pelin Turker, Elvan Bakar
doaj +1 more source
Journal of Neurology, Neurosurgery & Psychiatry, 1974 In 10 patients with Parkinsonism, treatment with L-dopa was associated with a rise in the skin conductance level and its fluctuations, an increased electromyographic activity in the frontalis muscle, and with faster reaction times. The change of skin conductance in response to a loud noise also increased and its habituation to the repetition of the ...
T B, Horvath, R A, Meares
openaire +2 more sources
Neurobiology of Disease, 2021 L-dopa is the most effective drug used to date for management of Parkinson's disease symptoms. Unfortunately, long-term administration of L-dopa often results in development of motor disorders, including dyskinesias.
Agustina Zorgniotti +3 more
doaj +1 more source
GABA storage and release in the medial globus pallidus in L-DOPA-induced dyskinesia priming
Neurobiology of Disease, 2020 Levo-dihydroxyphenylalanine (L-DOPA) is the most effective treatment for Parkinson's disease; however, most patients develop uncontrollable abnormal involuntary movements known as L-DOPA-induced dyskinesia.
Haruo Nishijima +10 more
doaj +1 more source
An Overview of Methods for L-Dopa Extraction and Analytical Determination in Plant Matrices
Separations, 2022 L-dopa is a precursor of dopamine used as the most effective symptomatic drug treatment for Parkinson’s disease. Most of the L-dopa isolated is either synthesized chemically or from natural sources, but only some plants belonging to the Fabaceae family ...
Carmen Tesoro +5 more
doaj +1 more source