Results 191 to 200 of about 10,236,148 (357)

Spatiotemporal Progression Patterns of Striatal Dopamine Depletion and Cerebral Hypoperfusion in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background The identification of Parkinson's disease (PD) subtypes is crucial for predicting the disease course and designing personalized therapeutic strategies. Objectives The aim of the study was to characterize the heterogeneity of the spatiotemporal evolutionary patterns of striatal dopamine depletion and cerebral hypoperfusion in PD ...
Yeeun Sun, Youngseok Choi, Chan Wook Park, Han Kyu Na, Hye Sun Lee, Yun Joong Kim, Young H. Sohn, Phil Hyu Lee, Jeyeon Lee, Seok Jong Chung   +9 more
wiley   +1 more source

At the extreme limits of L-DOPA therapy: probable dopamine dysregulation and psychiatric complications in Parkinson's disease. [PDF]

BMJ Neurol Open
Oikarinen N, Ottela E, Rönkä J, Haanpää M, Niemelä S, Lees AJ, Kaasinen V.   +6 more
europepmc   +1 more source

Effects of chronic fructose overload on renal dopaminergic system: alteration of urinary L-dopa/dopamine index correlates to hypertension and precedes kidney structural damage

, 2017
Natalia L. Rukavina Mikusic, Nicolás M. Kouyoumdzian, Julieta S. Del Mauro, Gabriel Cao, Verónica Trida, Mariela M. Gironacci, Ana M. Puyó, Jorge E. Toblli, Belisario E. Fernández, Marcelo R. Choi   +9 more
openalex   +2 more sources

Statistical Analysis Between the Routes of Administration of L-Dopa and Digestive Dysfunctions in Parkinson Disease [PDF]

, 2019
Oana Criciotoiu, Diana Stanca, Daniela-Gabriela Glavan, Cecil Sorin Mirea, Adrian Mită, Veronica Calborean, Victor Gheorman, Ion Udriștoiu, Anda Lorena Dijmărescu, Dragoş Virgil Daviţoiu, Dan Ionuț Gheonea   +10 more
openalex   +1 more source

Gene Therapy for Amino Acid Decarboxylase Deficiency: Clinical and Imaging Outcomes in a French Cohort

Movement Disorders, EarlyView.
Abstract Background Intracerebral gene therapy is effective for amino acid decarboxylase (AADC) deficiency, but relationships between anatomical putaminal coverage, metabolic dynamics, and clinical recovery remain poorly understood. Objectives Assess safety, long‐term efficacy, and clinical–radiological correlations in a genetically diverse European ...
Clément Dunoyer, Gaëtan Poulen, Marie‐Céline François‐Heude, Eline Chauvet‐Piat, Bérénice Lecardonnel, Emmanuel Roze, Marie‐Ange Nguyen Morel, Domitille Gras, Adeline Quintard, Gaelle Baroux, Pierre Meyer, Philippe Coubes, Christophe Milesi, Julien Baleine, Chrystelle Sola, Vivien Szabo, Bénédicte Delye, Jana Haberlova, Mohamed Osman Eltahir Babiker, Mohammed Al Muqbil, Stéphanie Sanchez, Souad Touati, Nicolas Leboucq, Virginie Kouyoumdjian, Sylvia Sanquer, Denis Mariano‐Goulart, Thomas Roujeau, Agathe Roubertie   +27 more
wiley   +1 more source

Disruption of the l-DOPA Receptor Gpr143/OA1-Gene in Mice Creates a Unique Mixed Psychosis-Like Phenotype. [PDF]

Neuropsychopharmacol Rep
Goshima Y, Nakamura H, Koga M, Koyama J, Kimura Y, Vasishth MN, Snyder EY, Asai M, Sakai K, Masukawa D.   +9 more
europepmc   +1 more source

L-Dopa Modulation of Brain Connectivity in Parkinson’s Disease Patients: A Pilot EEG-fMRI Study [PDF]

, 2019
Stefania Evangelisti, Francesca Pittau, Claudia Testa, Giovanni Rizzo, Laura Ludovica Gramegna, Lorenzo Ferri, Ana Coito, Pietro Cortelli, Giovanna Calandra–Buonaura, Fabio Bisquoli, Claudio Bianchini, David Neil Manners, Lia Talozzi, Caterina Tonon, Raffaele Lodi, Paolo Tinuper   +15 more
openalex   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Effects of chemogenetic inhibition of serotonergic raphe-striatal neurons on L-DOPA-induced behaviors and neurochemistry in a rat model of Parkinson's disease. [PDF]

Acta Neuropathol Commun
Budrow CN, Bernal-Conde LD, Sandoval IM, Galfano A, Grezenko H, Velazquez A, Marmion DJ, Flores-Barrera E, Venkatesh S, Coyle M, Meyers K, Nguyen K, Holden H, Tseng KY, Bishop CR, Manfredsson FP.   +15 more
europepmc   +1 more source

Improve the Thermal Conductivity, Insulation Performance and Mechanical Properties of Silicone Rubber by Constructing EG‐PDA‐Cu Hybrid Nanoparticles

Journal of Polymer Science, EarlyView.
In this work, a novel expanded graphite‐supported nano‐copper polydopamine composite was designed and synthesized. The procedure involved first modifying EG via a mussel‐inspired technique to deposit a polydopamine coating, after which Cu2+ ions were reduced to immobilize copper nanoparticles onto the EG‐PDA substrate.
Xingrong Liu, Fan Xia, Dietmar Auhl
wiley   +1 more source