Results 231 to 240 of about 10,236,148 (357)

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Reduced Cortical Pyramidal Neuron Membrane Excitability and Synaptic Function in Parkinsonian Mice and Their Restoration by L-Dopa Treatment: Indirect Mediation by Striatal Dopaminergic Activity. [PDF]

Brain Sci
Chen H, Zhong M, Lin G, Liao FF, Zhou FM.   +4 more
europepmc   +1 more source

Cellular and behavioural effects of the adenosine A_2a receptor antagonist KW‐6002 in a rat model of l‐DOPA‐induced dyskinesia

, 2003
Martin Lundblad, Elisabetta Vaudano, M. Angela Cenci   +2 more
openalex   +2 more sources

Over-expression of renal LAT1 and LAT2 and enhanced L-DOPA uptake in SHR immortalized renal proximal tubular cells [PDF]

, 2004
Maria João Pinho, Paula Serrão, Pedro Gomes, Ulrich Hopfer, Pedro A. José, Patrı́cio Soares-da-Silva   +5 more
openalex   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, EarlyView.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Regulating astrocytic activity in the dorsal striatum mitigates L-dopa-induced dyskinesia in Parkinson's disease. [PDF]

Sci Rep
Ryu YK, Park HY, Kim JE, Seo HH, Lee CH, Kim KS.   +5 more
europepmc   +1 more source

Analyses and Comparisons of the Antimicrobial-Cytotoxic Effects and Molecular Docking Study of L-DOPA and L-DOPA Methyl Ester

Yüksek biyouyumluluk, düşük sitotoksisite ve gelişmiş antibakteriyel özelliklere sahip bileşiklerin sentezlenmesinin artanönemi güncel araştırmalarda açıkça görülmektedir.
Balcı, Hüseyin, Aysan, Arzu, Karaca, Tuğçe Deniz, Sert, Yusuf   +3 more
core  

The Parasitoid Wasp Glyptapanteles porthetriae Induces a Photoperiod‐Dependent Diapause‐Like State in Its Potential Overwintering Host Lasiocampa quercus

Entomologia Experimentalis et Applicata, EarlyView.
We evaluated Lasiocampa quercus as an overwintering host for the koinobiont larval endoparasitoid Glyptapanteles porthetriae by exposing parasitized larvae to different environmental conditions and comparing parasitoid development with that in the primary host Lymantria dispar.
Thomas Zankl, Christa Schafellner
wiley   +1 more source

Probing the Mechanism of l‑DOPA 2,3-Dioxygenase Using Synthetic Derivatives of 3,4-Dihydroxyhydrocinnamic Acid. [PDF]

ACS Omega
Demisew AT, Cohen JR, Gruss EG, Bui JD, Steiner JL, Xhafkollari G, Marasco RN, Betonio M, Strzeminski D, Leyes Porello S, Colabroy KL, Peterson LW.   +11 more
europepmc   +1 more source

Characterization of dermatan sulfate and chondroitin sulfate profiles during brain regeneration in Styela plicata

The FEBS Journal, EarlyView.
Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal, Samara de Oliveira Pimentel, Bruno da Costa Rodrigues, Mauro Sérgio Gonçalves Pavão, Rodrigo Nunes da Fonseca, Cintia Monteiro de Barros   +5 more
wiley   +1 more source