Results 191 to 200 of about 39,473 (264)

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano   +2 more
wiley   +1 more source

Neuroprotective effect of L-DOPA-induced interleukin-13 on striatonigral degeneration in cerebral ischemia. [PDF]

Cell Death Dis
Jeon E, Seo MS, Lkhagva-Yondon E, Lim YR, Kim SW, Kang YJ, Lee JS, Lee BD, Wi R, Won SY, Chung YC, Park ES, Kim E, Jin BK, Jeon MS.   +14 more
europepmc   +1 more source

Zein‐Based Adhesives: Sustainable Extraction and Application in Bioadhesive Technologies

Advanced Engineering Materials, Volume 28, Issue 13, 8 July 2026.
Zein is extracted from corn gluten meal using a simple and scalable process with high yield (~90%). The resulting protein is applied in bioadhesives modified with Ca2+ and Fe3+ ions, exhibiting substrate‐dependent adhesion. The findings demonstrate competitive bonding performance and highlight the role of ionic interactions in tuning adhesion ...
Paula Bertolino Sanvezzo, Daniela Winsley Valereto Friozi, Vinícius de Oliveira, Marcia Cristina Branciforti   +3 more
wiley   +1 more source

A computational strategy to improve the activity of tyrosine phenol-lyase for the synthesis of L-DOPA. [PDF]

Sci Rep
Xu J, Ye S, Guan F.
europepmc   +1 more source

Bridging Stability and Reactivity: Novel Dinucleating Ligand With Rigid Backbone Stabilizes a Cu2O2 Side‐On Peroxido Structure

European Journal of Inorganic Chemistry, Volume 29, Issue 19, 2 July 2026.
The herein‐developed tyrosinase model complex enables the transfer of tyrosinase‐like catalytic oxygenation activity into artificial systems. Therefore, it enables the use of molecular oxygen for oxygenation and oxidation of phenolic substrates at room temperature.
Rosalie Dalhoff, Christine Charlotte Müller, Alexander Hoffmann, Sonja Herres‐Pawlis   +3 more
wiley   +1 more source

L-DOPA Autoxidation: An Empirical Valence Bond Simulation of the Reactive Step. [PDF]

J Phys Chem B
Prah A, Mavri J.
europepmc   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, Volume 15, Issue 27, 17 July 2026.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Intracerebroventricular anaerobic dopamine in Parkinson's disease with L-dopa-related complications: a phase 1/2 randomized-controlled trial. [PDF]

Nat Med
Moreau C, Odou P, Labreuche J, Demailly A, Touzet G, Reyns N, Gouges B, Duhamel A, Barthelemy C, Lannoy D, Carta N, Palas B, Vasseur M, Marchand F, Ollivier T, Leclercq C, Potey C, Ouk T, Baigne S, Dujardin K, Carton L, Rolland AS, Devedjian JC, Foutel V, Deplanque D, Fisichella M, Devos D.   +26 more
europepmc   +1 more source

Minimally Invasive Delivery of Optical Nanosensors Using Injectable Hydrogels

Advanced Materials Interfaces, Volume 13, Issue 14, 21 July 2026.
Injectable peptide hydrogels offer a minimally invasive delivery platform for single‐walled carbon nanotube (SWCNT)‐based near‐infrared fluorescent sensors, enabling real‐time measurement of drug concentrations. Encapsulated SWCNTs show a dose‐dependent fluorescence response across physiologically relevant concentrations and retain their fluorescence ...
Shirel Kleiner, Gili Bisker
wiley   +1 more source

L-Dopa Might Be Insufficient to Suppress Development of Prolactinomas in Dihydropteridine Reductase-Deficiency Patients. [PDF]

JCEM Case Rep
Diaz-Moreno U, Gan CG, Pujari D, Gan HW, Batzios S.   +4 more
europepmc   +1 more source