Results 181 to 190 of about 39,513 (265)

Staurosporine Drives Non‐Canonical Melanocyte Maturation by Coupling β‐Catenin Signaling to Actin‐Dependent Dendrite Remodeling

Pigment Cell &Melanoma Research, Volume 39, Issue 5, September 2026.
Staurosporine drives non‐canonical melanocyte maturation through β‐catenin‐dependent actin remodeling. Functional maturation enhances dendrite architecture and melanogenic differentiation without inducing melanocyte proliferation, providing a biological framework for restoring functional melanocytes in acquired hypopigmentary disorders.
Kangning Xu, Lingli Yang, Sylvia Lai, Fei Yang, Yasutaka Kuroda, Daisuke Tsuruta, Ichiro Katayama   +6 more
wiley   +1 more source

Exploring L-tyrosine and L-DOPA biosynthesis in faba bean ( Vicia faba L.)

Xia X, Straube H, Blume D, Mancinotti D, Dueholm B, Escobar-Herrera L, Andersen SU, Geu-Flores F, Sheehan H.   +8 more
europepmc   +1 more source

Dietary L-3,4-dihydroxyphenylalanine (L-DOPA) augments cuticular melanization in Anopheles mosquitos reducing their lifespan and malaria burden. [PDF]

Nat Commun
Camacho E, Dong Y, Chrissian C, Cordero RJB, Saraiva RG, Anglero-Rodriguez Y, Smith DFQ, Jacobs E, Hartshorn I, Patiño-Medina JA, DePasquale M, Dziedzic A, Jedlicka A, Smith B, Mlambo G, Tripathi A, Broderick NA, Stark RE, Dimopoulos G, Casadevall A.   +19 more
europepmc   +1 more source

From Fragments to Function: Novel Hydrazone Derivatives as Monoamine Oxidase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Twelve N‐acylhydrazone derivatives (5a–f, 6a–f) were synthesized and characterized. Compounds displayed potent submicromolar inhibition against both MAO‐A and MAO‐B. Compound 6e exhibited the strongest activity (IC50 = 0.073 μM for MAO‐A; 0.064 μM for MAO‐B). Kinetic and docking analyses confirmed reversible, competitive inhibition via FAD interaction.
Hasan Erdinç Sellitepe, Ahmet Buğra Aksel, Ezgi Pehlivanlar Yavrucu, Hilal Zıvalı, Begüm Nurpelin Sağlık Özkan, İnci Selin Doğan   +5 more
wiley   +1 more source

Measurement of Glutamate Suppression in a 6-OHDA-Induced Dopamine Deficiency Rat Model Following Acute Single-Dose L-DOPA Using GluCEST/MRS. [PDF]

Biomedicines
Nakano T, Bono K, Ueda J, Ohmi M, Saito S.   +4 more
europepmc   +1 more source

Rational Design of Multifunctional Tacrine Derivatives as Candidates for the Treatment of Alzheimer and Parkinson Diseases

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
We present a set of multifunctional tacrine derivatives, designed with the CADMA‐Chem protocol, aimed for Alzheimer and Parkinson diseases. Of the tacrines designed, TAC‐674 and TAC‐678 are the best candidates to act as multifunctional antioxidants and neuroprotectors for Alzheimer and Parkinson diseases, respectively.
Eugenia Dzib, Luis Felipe Hernández‐Ayala, Silvana Silva‐Aguirre, Annia Galano   +3 more
wiley   +1 more source

Interplay of defects and dopants in <i>l</i>-Dopa -aided UiO-66 for superprotonic conductivity. [PDF]

RSC Adv
Selvakumar P, Somu SK, Swaminathan SV, Pal A, Nechikott AA, Nayak PK, Kundu T.   +6 more
europepmc   +1 more source

Ambient Light‐Activatable Luminescent Particle‐Embedded Conformal Patch for Photochemical Tissue Bonding and Photobiomodulated Healing

Advanced Materials, Volume 38, Issue 44, 7 August 2026.
We report a wearable photonic patch integrating room light‐ and sunlight‐activatable luminescent particles (RSLPs) for both photochemical tissue bonding and photobiomodulation. RSLPs harvest ambient light and emit red luminescence to drive chlorin e6–mediated collagen crosslinking.
Kyungjoo Jo, Seong‐Jong Kim, Seung Oh Jung, Kyeongtaek Lee, Mungu Kim, Kwanghyeon Park, Yewon Seo, Boram Park, Dongchul Jo, Jongshin Kim, Jin Huh, Hyemin Kim, Sei Kwang Hahn   +12 more
wiley   +1 more source

L-Dopa-induced changes in aperiodic bursts dynamics relate to individual clinical improvement in Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Agouram H, Neri M, Angiolelli M, Depannemaecker D, Bahuguna J, Schwey A, Régis J, Carron R, Malfait N, Eusebio A, Daucé E, Sorrentino P.   +11 more
europepmc   +1 more source

Modulus‐Switchable Miniature Robots for Biomedical Applications: A Review

Advanced Robotics Research, Volume 2, Issue 4, August 2026.
Materials, robot designs, proof‐of‐concept functions, and biomedical applications of modulus‐switchable miniature robots. Miniature soft robots have shown great potential in biomedical applications due to their excellent controllability and suitable mechanical properties in biological environments.
Chunyun Wei, Yibin Wang, Jiangfan Yu
wiley   +1 more source