Results 161 to 170 of about 75,185 (305)

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

No New Relevant Treatment Options for L-DOPA-Induced Dyskinesia from a Clinician's Point of View. [PDF]

Neurol Int
Müller T.
europepmc   +1 more source

Diagnosis of Growth Hormone Deficiency in Children: Comparative Performance of Arginine Versus Glucagon as the First Stimulation Test

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Growth hormone deficiency (GHD) diagnosis typically requires the performance of two sequential stimulation tests. Glucagon stimulation test (GST) and arginine stimulation test (AST) are widely used. This study aimed to determine the most suitable order of tests.
David Shaki, Daria Shvarts, Eli Hershkovitz, Lior Carmon, Hazan Guy, Bachar Yoav, Alon Haim   +6 more
wiley   +1 more source

At the extreme limits of L-DOPA therapy: probable dopamine dysregulation and psychiatric complications in Parkinson's disease. [PDF]

BMJ Neurol Open
Oikarinen N, Ottela E, Rönkä J, Haanpää M, Niemelä S, Lees AJ, Kaasinen V.   +6 more
europepmc   +1 more source

The Parasitoid Wasp Glyptapanteles porthetriae Induces a Photoperiod‐Dependent Diapause‐Like State in Its Potential Overwintering Host Lasiocampa quercus

Entomologia Experimentalis et Applicata, EarlyView.
We evaluated Lasiocampa quercus as an overwintering host for the koinobiont larval endoparasitoid Glyptapanteles porthetriae by exposing parasitized larvae to different environmental conditions and comparing parasitoid development with that in the primary host Lymantria dispar.
Thomas Zankl, Christa Schafellner
wiley   +1 more source

Disruption of the l-DOPA Receptor Gpr143/OA1-Gene in Mice Creates a Unique Mixed Psychosis-Like Phenotype. [PDF]

Neuropsychopharmacol Rep
Goshima Y, Nakamura H, Koga M, Koyama J, Kimura Y, Vasishth MN, Snyder EY, Asai M, Sakai K, Masukawa D.   +9 more
europepmc   +1 more source

Offspring Dependency Is Not Reflected in the Social Immunity of Three Burying Beetle Species

Entomologia Experimentalis et Applicata, EarlyView.
Nicrophorus pustulatus, Nicrophorus vespilloides, and Nicrophorus orbicollis are three burying beetle species that differ both in their ecology and in the dependency of their offspring on parental care. This gradient of offspring dependency might be reflected in the parents' social immunity capabilities and/or investment.
Leon Müller, Laura Cherpion, Maximilian Körner   +2 more
wiley   +1 more source

Effects of chemogenetic inhibition of serotonergic raphe-striatal neurons on L-DOPA-induced behaviors and neurochemistry in a rat model of Parkinson's disease. [PDF]

Acta Neuropathol Commun
Budrow CN, Bernal-Conde LD, Sandoval IM, Galfano A, Grezenko H, Velazquez A, Marmion DJ, Flores-Barrera E, Venkatesh S, Coyle M, Meyers K, Nguyen K, Holden H, Tseng KY, Bishop CR, Manfredsson FP.   +15 more
europepmc   +1 more source

Time‐calibrated relationships of a rare cave catfish (Trichomycterus rubbioli): Shedding light on troglobitic lifestyle origin in the Brazilian caatinga

Journal of Fish Biology, EarlyView.
Abstract Catfishes of the subfamily Trichomycterinae comprise the most diverse fish group with species adapted to live in Neotropical caves, but past evolutionary scenarios that have driven the origin of these troglobitic species remain unknown. We herein investigate the phylogenetic position of the cave‐restricted Trichomycterus rubbioli, endemic to ...
Wilson J. E. M. Costa, Paulo J. Vilardo, José Leonardo O. Mattos, Axel M. Katz, Valter M. Azevedo‐Santos, Pedro L. C. Uzeda, Rodrigo L. Ferreira   +6 more
wiley   +1 more source

l-DOPA-Containing Protein Autoxidation: An Empirical Valence Bond Simulation of the Rate-Limiting Step. [PDF]

J Phys Chem B
Oanca G, Prah A, Åqvist J, Mavri J.
europepmc   +1 more source