Results 191 to 200 of about 39,480 (265)

Multiple transitions to high l-DOPA 4,5-dioxygenase activity reveal molecular pathways to convergent betalain pigmentation in Caryophyllales. [PDF]

New Phytol
Walker-Hale N, Guerrero-Rubio MA, Brockington SF.   +2 more
europepmc   +1 more source

Repercussions of Diagnostic Delay in Rare Diseases

Journal of Genetic Counseling, Volume 35, Issue 4, August 2026.
ABSTRACT Rare diseases (RDs) are often subject to diagnostic delays due to their low prevalence, clinical variability, and limited professional awareness. This scoping review aimed to map the literature on these delays, examining their clinical, emotional, and socioeconomic consequences.
Luisa Rezende Batista, Luiza Fernandes Valente, Fernando Spina, Davi Said Gonçalves Celso, Israel Gomy, Christiane Mariotini‐Moura   +5 more
wiley   +1 more source

L-DOPA Induces Spatially Discrete Changes in Gene Expression in the Forebrain of Mice with a Progressive Loss of Dopaminergic Neurons. [PDF]

Mol Neurobiol
Radlicka-Borysewska A, Ziemiańska M, Zięba M, Szumiec Ł, Bagińska M, Chrószcz M, Gołda S, Hajto J, Korostyński M, Kreiner G, Pera J, Piechota M, Rodriguez Parkitna J.   +12 more
europepmc   +1 more source

Current Insight into Human Ornithine Aminotransferase: A Review

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 8, Page 1431-1441, August 2026.
ABSTRACT Human ornithine aminotransferase (hOAT) is a mitochondrial matrix pyridoxal‐5′‐phosphate enzyme (PLP) that catalyzes the reversible transfer of the δ‐amino group of L‐ornithine (L‐Orn) to α‐ketoglutarate (α‐KG) yielding glutamate‐5‐semialdehyde (GSA) and glutamate. GSA is prone to cyclize to Δ1‐pyrroline‐5‐carboxylate.
Fulvio Floriani, Carla Borri Voltattorni, Riccardo Montioli   +2 more
wiley   +1 more source

Impulsive-compulsive behaviours and striatal neuroactivity in mildly parkinsonian rats under D2/3 agonist and L-DOPA treatment. [PDF]

NPJ Parkinsons Dis
Wolfschlag M, Espa E, Skovgård K, Halje P, Cenci MA.   +4 more
europepmc   +1 more source

Conservative roots confer a larger microbial carbon pump efficacy than acquisitive roots by regulating microbial life‐history strategy

Functional Ecology, Volume 40, Issue 8, Page 2617-2627, August 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Root activity creates unique microbial hotspots in the rhizosphere by influencing the metabolic activities of surrounding soil microorganisms, profoundly regulating the dynamics of soil organic carbon (SOC). However, how root economic strategies affect the formation and
Qiyu Tan, Peipei Zhang, Na Li, Guangru Wang, Wenbo Pang, Huangxin Zhang, Mingzhou Zhang, Qitong Wang, Huajun Yin   +8 more
wiley   +1 more source

Diabetic striatopathy: Hyperglycemic chorea/ballism successfully treated with L-dopa. [PDF]

J Diabetes Investig
Tsukaguchi R, Hasebe M, Shibue K, Hamasaki A.   +3 more
europepmc   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, Volume 183, Issue 15, Page 4091-4110, August 2026.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Arterial spin labeling MRI based perfusion pattern related to motor dysfunction and L-DOPA reactivity in Parkinson's disease. [PDF]

Neuroimage Clin
Zheng Q, Yuan W, Wen J, Qin J, Wu C, Wu H, Duanmu X, Tan S, Guo T, Zhou C, Wu J, Chen J, Zeng Q, Fang Y, Zhu B, Yan Y, Tian J, Zhang B, Zhang M, Guan X, Xu X.   +20 more
europepmc   +1 more source

Diagnosis of Growth Hormone Deficiency in Children: Comparative Performance of Arginine Versus Glucagon as the First Stimulation Test

Clinical Endocrinology, Volume 105, Issue 2, Page 213-219, August 2026.
ABSTRACT Objective Growth hormone deficiency (GHD) diagnosis typically requires the performance of two sequential stimulation tests. Glucagon stimulation test (GST) and arginine stimulation test (AST) are widely used. This study aimed to determine the most suitable order of tests.
David Shaki, Daria Shvarts, Eli Hershkovitz, Lior Carmon, Hazan Guy, Bachar Yoav, Alon Haim   +6 more
wiley   +1 more source