Results 81 to 90 of about 11,284,409 (311)

Temporal administration of entacapone with slow release L-dopa: pharmacokinetic profile and clinical outcome

, 2004
Entacapone is a specific, peripherally acting catechol- O-methyltransferase (COMT) inhibitor that prevents peripheral degradation of L-dopa, thus improving its bioavailability.
A. Bassi, PIERANTOZZI M., M. Pierantozzi, BRUSA L., LUNARDI G., Stanzione, P, Giacomini, P, FEDELE, ERNESTO, PIERANTOZZI, MARIANGELA, Fedele, E, G. Lunardi, Bassi, A, E. Fedele, GIACOBINI P., Lunardi, G, GIACOMINI, Patrizia, Pierantozzi, M, STANZIONE P., Brusa, L, P. Stanzione, BASSI A., STANZIONE, PAOLO, L. Brusa   +22 more
core   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

L-DOPA administration improved symptoms and motor deficits of PD marmosets.

, 2018
(A) Cumulative PDRS scores of the marmosets during the on and off L-DOPA treatments. The parkinsonian marmosets (n = 3) showed improvement in PD disabilities following L-DOPA treatment (B) Motor subscale scores showing progression of individual ...
Marcel M. Daadi (40597), Gourav R. Choudhury (5680574)   +1 more
core   +1 more source

A Disulfide‐Sticker Strategy for Marine Adhesive Coatings: From Deciphering Self‐Assembly Mechanism to Functional Application in Hair Regeneration

Advanced Science, EarlyView.
A disulfide‐sticker strategy, coupled with Ca2+ coordination, drives the hierarchical self‐assembly of a recombinant scallop adhesive protein into fishnet‐like nanostructures, affording a coating with versatile wet adhesion and intrinsic antioxidant activity. This biocompatible coating markedly promotes hair regeneration by activating follicular niches,
Lulu Wang, Juan Yang, Xin Jiang, Zhanghui Zheng, Hongyu Wei, Na Li, Xiangqiang Chu, Weizhi Liu   +7 more
wiley   +1 more source

L-DOPA-induced signaling pathways and neuroepigenetic mechanisms in experimental parkinsonism and dyskinesia

, 2014
In patients with Parkinson’s disease (PD), the restoration of depleted striatal dopamine by chronic administration of its precursor, L-DOPA, results in the emergence of debilitating involuntary movements.
Michael Feyder (18637498)
core  

Alpha and beta EEG power reflects L-dopa acute administration in parkinsonian patients [PDF]

, 2014
Aim: To evaluate the effect of an acute L-dopa administration on eye-closed resting state electroencephalographic (EEG) activity of cognitively preserved Parkinsonian patients.
Di Biase L, CURCIO, GIUSEPPE, Salomone G, Melgari J. M, Tombini M, Fabrizio E, Trotta L, Scrascia F, Rossini PM, Mastrolilli F, Vernieri F., Fini R   +11 more
core   +1 more source

Polydopamine Nanoparticle‐Mediated Precise Near‐Infrared Optical Stimulation for Cognitive Enhancement

Advanced Science, EarlyView.
Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou, Qiong Xue, Su‐Xuan Hou, Ke‐Yao Zhang, Wei‐Tong Pan, Ting‐Ting Zeng, Yu‐Ge Wang, Daqing Ma, Chenguang Zhao, Pan‐Miao Liu, Jian‐Jun Yang   +10 more
wiley   +1 more source

Changes in extracellular and intracellular L-DOPA concentration in methyl-L-DOPA-pretreated primary cultured striatal astrocytes after withdrawal of L-DOPA.

, 2014
Striatal astrocytes were treated with methyl-L-DOPA (200 µM) for 4 h or 8 h (filled bar). Furthermore, astrocytes pre-treated with methyl-L-DOPA for 8 h were incubated in fresh medium for 1 h or 4 h (gray bar).
Masato Asanuma (420841), Norio Ogawa (420846), Francisco J. Diaz-Corrales (420843), Shinki Murakami (564868), Ikuko Miyazaki (420842)   +4 more
core   +1 more source

l-Dopa induced dyskinesias in Parkinsonian mice: Disease severity or l-Dopa history [PDF]

, 2015
In Parkinson’s disease, the efficacy of l-Dopa treatment changes over time, as dyskinesias emerge with previously beneficial doses. Using MitoPark mice, that models mitochondrial failure in dopamine (DA) neurons and mimics the progressive loss of ...
Cadet, Jean-Lud, Shan, Lufei, Bäckman, Cristina M., Diaz, Oscar, Olson, Lars, Zhang, Yajun, Ladenheim, Bruce, Hoffer, Barry J., Chiang, Yung-Hsiao   +8 more
core   +1 more source

Mass spectrometry imaging identifies abnormally elevated brain L-DOPA levels and extrastriatal monoaminergic dysregulation in L-DOPA-induced dyskinesia

, 2021
L-DOPA treatment for Parkinson's disease frequently leads to dyskinesias, the pathophysiology of which is poorly understood. We used MALDI-MSI to map the distribution of L-DOPA and monoaminergic pathways in brains of dyskinetic and nondyskinetic primates.
Crossman, Alan R., Fernagut, Pierre-Olivier,, Fridjonsdottir, Elva,, Vallianatou, Theodosia, Bezard, Erwan, Fernagut, Pierre-Olivier, Schembri, Luke, Bezard, Erwan,, Shariatgorji, Mohammadreza,, Schembri, Luke S, Andrén, Per, Nilsson, Anna,, Crossman, Alan R.,, Odell, Luke, Crossman, Alan, Svenningsson, Per, Andrén, Per E., Odell, Luke R.,, Fridjonsdottir, Elva, Andrén, Per E.,, Shariatgorji, Mohammadreza, Nilsson, Anna, Shariatgorji, Reza, Vallianatou, Theodosia,, Schembri, Luke S,, Svenningsson, Per,, Odell, Luke R.   +26 more
core   +1 more source