Results 101 to 110 of about 11,284,409 (311)
Annals of Surgery, 1976 The use of L-Dopa in hepatic coma has been the subject of numerous reports since 1970. The following represents our experience with a rather heterogenous group of patients treated at the Massachusetts General Hospital over the past 4 years. Thirty-five patients with severe liver disease, a mean age of 53 +/- 3.5 years, including nutritional cirrhosis ...
J E, Fischer +3 more
openaire +3 more sources
L-DOPA causes mitochondrial dysfunction in vitro: A novel mechanism of L-DOPA toxicity uncovered
, 2019 © 2019 Elsevier Ltd In Parkinson's disease (PD), as in many other neurodegenerative disorders, mitochondrial dysfunction, protein misfolding, and proteotoxic stress underly the disease process.
Djordjevic, SP +4 more
core +1 more source
Angewandte Chemie International Edition, EarlyView.Renewable guaiacols are rapidly oxidized by phenyliodine(III)diacetate to masked ortho‐quinones, giving a new class of monomers that undergo selective Michael‐type polyaddition with multithiols to from thiol‐guaiacol connectivity‐bearing polymers. The activation applies to discrete monomers and directly to lignin, enabling two‐component adhesives that ...
Dominik P. Hoch +7 more
wiley +1 more source
l-DOPA and Its Receptor GPR143: Implications for Pathogenesis and Therapy in Parkinson’s Disease
Frontiers in Pharmacology, 2019 l-3,4-Dihydroxyphenylalanine (l-DOPA) is the most effective therapeutic agent for Parkinson’s disease (PD). l-DOPA is traditionally believed to be an inert amino acid that exerts actions and effectiveness in PD through its conversion to dopamine.
Yoshio Goshima +4 more
doaj +1 more source
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
Atomically precise metal cluster enzymes for pathological tissue regeneration
BMEMat, EarlyView.Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong +11 more
wiley +1 more source
, 1982 Urinary output of endogenous monoamine oxidase inhibitor was significantly greater in a group of postwithdrawal alcoholics than in controls. An oral dose of 0.5 g of L-dopa reduced output to control values in the alcoholics, but in the controls ...
Bhattacharya, S.K. +6 more
core
Protective Effects of L-Dopa and Carbidopa Combined Treatments on Human Catecholaminergic Cells
, 2012 Parkinson's disease (PD) is one of the most common neurodegenerative disorders characterized by decreased levels of the neurotransmitter dopamine (DA) in the striatum of the brain, as a result of degeneration of DA neurons.
COZZI, Renata +7 more
core +1 more source
Delayed O-methylation of L-DOPA in MB-COMT-deficient mice after oral administration of L-DOPA and carbidopa [PDF]
, 2017 1.Catechol-O-methyltransferase (COMT) is involved in the O-methylation of l-DOPA, dopamine, and other catechols. The enzyme is expressed in two isoforms: soluble (S-COMT), which resides in the cytoplasm, and membrane-bound (MB-COMT), which is anchored to
Anne Tammimäki +5 more
core +1 more source
BMEMat, EarlyView.Synthesis of QZCaCO3‐PEG to synergistically enhance the immunogenicity of radiotherapy through concurrent Zn2+‐induced cancer cell pyroptosis and Que‐mediated hypoxia amelioration through sequentially suppressing TGF‐β secretion and ECM deposition. Abstract Radiotherapy has demonstrated broad applications in treating solid tumors, but the hostile tumor
Chunjie Wang +9 more
wiley +1 more source