Results 161 to 170 of about 11,284,409 (311)

Sex and Diet Biased Effect of L-DOPA on Iron Accumulation in the Ventral Midbrain. [PDF]

J Neurochem
Serpa RO, Tufano E, Palsa K, Helmuth TB, Mills-Huffnagle S, Kant M, Connor JR.   +6 more
europepmc   +1 more source

Challenges of Pain in Parkinson's Disease: Results from the OCEAN Study

Movement Disorders, EarlyView.
Abstract Background Pain is a common non‐motor symptom in Parkinson’s disease (PD) and is often associated to fluctuations. Objective The OpiCapone Effect on motor fluctuations and pAiN (OCEAN) study evaluated the effect of opicapone on fluctuation‐related pain when added to levodopa therapy in PD patients.
Kallol Ray Chaudhuri, Joaquim J. Ferreira, Angelo Antonini, Olivier Rascol, Monica M. Kurtis, Alexander Storch, José‐Francisco Rocha, Raquel Costa, Diogo Magalhães, Guillermo Castilla‐Fernández, Helena C. Brigas, Joerg Holenz, Per Odin, on behalf of the OCEAN study group   +13 more
wiley   +1 more source

Dopamine 2 receptor ablation from cholinergic neurons attenuates L-DOPA induced dyskinesias. [PDF]

Front Aging Neurosci
Uribe-Cano S, Malave L, Kottmann AH.
europepmc   +1 more source

A Phase 1 Study of Convection‐Enhanced Delivery of Intraputaminal AAV2‐GDNF in Advanced Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a progressive neurodegenerative disorder. Neurotrophic therapeutic approaches have been limited in part by incomplete delivery to the putamen. We developed image‐guided convection‐enhanced delivery with real‐time monitoring to improve intraputaminal distribution of neurotrophic gene therapy. Objectives To
John D. Heiss, Debra J. Ehrlich, Codrin Lungu, Joseph Y. Choi, Gretchen Scott, Irene Dustin, Dima A. Hammoud, Peter Herscovitch, Russell R. Lonser, Kareem A. Zaghloul, Krystof Bankiewicz   +10 more
wiley   +1 more source

No New Relevant Treatment Options for L-DOPA-Induced Dyskinesia from a Clinician's Point of View. [PDF]

Neurol Int
Müller T.
europepmc   +1 more source

Evaluation of L-Dopa Biotransformation during Repeated L-Dopa Infusion into the Striatum in Freely-Moving Young and Old Rats

, 2008
The aim of this study was to assess changes in L-3, 4- dihydroxyphenylalanine (L-DOPA) biotransformation in response to two-pulse infusion of L-DOPA into the striatum of freely-moving young (3-4 month) and old (21-26 month) male Wistar rats. In addition,
SHUI, HAO-AI;PENG, YING-I;WU, RUEY-MEEI;TSAI, YUAN-FEEN, 稅皓靄;彭英毅;吳瑞美;蔡元奮   +1 more
core  

Severe Lower Limb and Abdominal Edema Associated with Subcutaneous Apomorphine Infusion

Movement Disorders Clinical Practice, EarlyView.
Guillaume Costentin, David Maltête
wiley   +1 more source

Spatiotemporal Progression Patterns of Striatal Dopamine Depletion and Cerebral Hypoperfusion in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background The identification of Parkinson's disease (PD) subtypes is crucial for predicting the disease course and designing personalized therapeutic strategies. Objectives The aim of the study was to characterize the heterogeneity of the spatiotemporal evolutionary patterns of striatal dopamine depletion and cerebral hypoperfusion in PD ...
Yeeun Sun, Youngseok Choi, Chan Wook Park, Han Kyu Na, Hye Sun Lee, Yun Joong Kim, Young H. Sohn, Phil Hyu Lee, Jeyeon Lee, Seok Jong Chung   +9 more
wiley   +1 more source

At the extreme limits of L-DOPA therapy: probable dopamine dysregulation and psychiatric complications in Parkinson's disease. [PDF]

BMJ Neurol Open
Oikarinen N, Ottela E, Rönkä J, Haanpää M, Niemelä S, Lees AJ, Kaasinen V.   +6 more
europepmc   +1 more source

Assessment of pharmacokinetic interaction of L-dopa and benserazide : animal model, mechanistic mathematical models, and allometric scaling across species [PDF]

, 2004
Grange, Susanna Sarah
core   +1 more source