Results 161 to 170 of about 13,238,937 (304)

MSN Templated with L-Dopa Amide Derivatives Outperforms the Efficiency of Free-L-Dopa in Reducing Parkinson's Behavioral Dysfunction in Mice. [PDF]

Int J Nanomedicine
Onrubia-Márquez M, Garcia MM, Navas F, Martínez-Erro S, Martín A, Morales V, Delaval J, Merchán-Sánchez L, Sánchez-Robles EM, Paniagua NA, Rodríguez-Rivera C, Sanz R, Goicoechea C, García-Muñoz RA.   +13 more
europepmc   +1 more source

A small molecule reduces both parkinsonism and l-dopa-induced dyskinesia in animal models of Parkinson's disease. [PDF]

Sci Transl Med
Bordbar A, Bloem B, Lloyd C, Johnston TH, Schneider JS, Bezard E, Pioli E, Li Q, Tawfeeq C, Vu Pham N, Huber G, Wu J, Hill MP, Brotchie JM, McCammon JA, Herberg FW, Taylor S, Weiner DM, Merchant K, Famili I.   +19 more
europepmc   +1 more source

Challenges of Pain in Parkinson's Disease: Results from the OCEAN Study

Movement Disorders, EarlyView.
Abstract Background Pain is a common non‐motor symptom in Parkinson’s disease (PD) and is often associated to fluctuations. Objective The OpiCapone Effect on motor fluctuations and pAiN (OCEAN) study evaluated the effect of opicapone on fluctuation‐related pain when added to levodopa therapy in PD patients.
Kallol Ray Chaudhuri, Joaquim J. Ferreira, Angelo Antonini, Olivier Rascol, Monica M. Kurtis, Alexander Storch, José‐Francisco Rocha, Raquel Costa, Diogo Magalhães, Guillermo Castilla‐Fernández, Helena C. Brigas, Joerg Holenz, Per Odin, on behalf of the OCEAN study group   +13 more
wiley   +1 more source

L-DOPA Promotes Post-Treatment Neurovascular and Synaptic Homeostasis in Early Diabetic Retinopathy. [PDF]

Invest Ophthalmol Vis Sci
Chlan E, Li C, Bales KL, Wood LB, Pardue MT.   +4 more
europepmc   +1 more source

A Phase 1 Study of Convection‐Enhanced Delivery of Intraputaminal AAV2‐GDNF in Advanced Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a progressive neurodegenerative disorder. Neurotrophic therapeutic approaches have been limited in part by incomplete delivery to the putamen. We developed image‐guided convection‐enhanced delivery with real‐time monitoring to improve intraputaminal distribution of neurotrophic gene therapy. Objectives To
John D. Heiss, Debra J. Ehrlich, Codrin Lungu, Joseph Y. Choi, Gretchen Scott, Irene Dustin, Dima A. Hammoud, Peter Herscovitch, Russell R. Lonser, Kareem A. Zaghloul, Krystof Bankiewicz   +10 more
wiley   +1 more source

L-DOPA influences transferrin-dependent iron release at the blood-brain barrier. [PDF]

Fluids Barriers CNS
Serpa RO, Palsa K, Tufano E, Laukhuff H, Spiegelman VS, Elcheva I, Connor JR.   +6 more
europepmc   +1 more source

Severe Lower Limb and Abdominal Edema Associated with Subcutaneous Apomorphine Infusion

Movement Disorders Clinical Practice, EarlyView.
Guillaume Costentin, David Maltête
wiley   +1 more source

Spatiotemporal Progression Patterns of Striatal Dopamine Depletion and Cerebral Hypoperfusion in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background The identification of Parkinson's disease (PD) subtypes is crucial for predicting the disease course and designing personalized therapeutic strategies. Objectives The aim of the study was to characterize the heterogeneity of the spatiotemporal evolutionary patterns of striatal dopamine depletion and cerebral hypoperfusion in PD ...
Yeeun Sun, Youngseok Choi, Chan Wook Park, Han Kyu Na, Hye Sun Lee, Yun Joong Kim, Young H. Sohn, Phil Hyu Lee, Jeyeon Lee, Seok Jong Chung   +9 more
wiley   +1 more source

Sex and Diet Biased Effect of L-DOPA on Iron Accumulation in the Ventral Midbrain. [PDF]

J Neurochem
Serpa RO, Tufano E, Palsa K, Helmuth TB, Mills-Huffnagle S, Kant M, Connor JR.   +6 more
europepmc   +1 more source

Assessment of pharmacokinetic interaction of L-dopa and benserazide : animal model, mechanistic mathematical models, and allometric scaling across species [PDF]

, 2004
Grange, Susanna Sarah
core   +1 more source