Results 101 to 110 of about 13,238,937 (304)

Transformative Masked Ortho‐Quinone Chemistry: From Direct Guaiacol Activation to Lignin‐Based Adhesives

Angewandte Chemie International Edition, EarlyView.
Renewable guaiacols are rapidly oxidized by phenyliodine(III)diacetate to masked ortho‐quinones, giving a new class of monomers that undergo selective Michael‐type polyaddition with multithiols to from thiol‐guaiacol connectivity‐bearing polymers. The activation applies to discrete monomers and directly to lignin, enabling two‐component adhesives that ...
Dominik P. Hoch, Keven Walter, Oliver Sipura, Jana Falkenhagen, Xinyang Peng, Leon Gerndt, Hamy Nguyen, Hans G. Börner   +7 more
wiley   +1 more source

L-Dopa in Hepatic Coma

Annals of Surgery, 1976
The use of L-Dopa in hepatic coma has been the subject of numerous reports since 1970. The following represents our experience with a rather heterogenous group of patients treated at the Massachusetts General Hospital over the past 4 years. Thirty-five patients with severe liver disease, a mean age of 53 +/- 3.5 years, including nutritional cirrhosis ...
J E, Fischer, F J, Funovics, H A, Falcao, R I, Wesdorp   +3 more
openaire   +3 more sources

Changes in extracellular and intracellular L-DOPA concentration in methyl-L-DOPA-pretreated primary cultured striatal astrocytes after withdrawal of L-DOPA.

, 2014
Striatal astrocytes were treated with methyl-L-DOPA (200 µM) for 4 h or 8 h (filled bar). Furthermore, astrocytes pre-treated with methyl-L-DOPA for 8 h were incubated in fresh medium for 1 h or 4 h (gray bar).
Masato Asanuma (420841), Norio Ogawa (420846), Francisco J. Diaz-Corrales (420843), Shinki Murakami (564868), Ikuko Miyazaki (420842)   +4 more
core   +1 more source

Mass spectrometry imaging identifies abnormally elevated brain L-DOPA levels and extrastriatal monoaminergic dysregulation in L-DOPA-induced dyskinesia

, 2021
L-DOPA treatment for Parkinson's disease frequently leads to dyskinesias, the pathophysiology of which is poorly understood. We used MALDI-MSI to map the distribution of L-DOPA and monoaminergic pathways in brains of dyskinetic and nondyskinetic primates.
Crossman, Alan R., Fernagut, Pierre-Olivier,, Fridjonsdottir, Elva,, Vallianatou, Theodosia, Bezard, Erwan, Fernagut, Pierre-Olivier, Schembri, Luke, Bezard, Erwan,, Shariatgorji, Mohammadreza,, Schembri, Luke S, Andrén, Per, Nilsson, Anna,, Crossman, Alan R.,, Odell, Luke, Crossman, Alan, Svenningsson, Per, Andrén, Per E., Odell, Luke R.,, Fridjonsdottir, Elva, Andrén, Per E.,, Shariatgorji, Mohammadreza, Nilsson, Anna, Shariatgorji, Reza, Vallianatou, Theodosia,, Schembri, Luke S,, Svenningsson, Per,, Odell, Luke R.   +26 more
core   +1 more source

Marine‐Derived Type I Collagen From Scyliorhinus canicula: Extraction, Characterization, and Biomedical Applications

Journal of Applied Polymer Science, EarlyView.
Marine‐derived type I collagen is extracted from Scyliorhinus canicula skin and characterized by physicochemical and morphological analyses. The collagen exhibits excellent biocompatibility, promotes wound healing, reduces inflammatory mediators, and inhibits melanogenesis.
Marwa Rejeb, Aida Lahmar, Arem Selmi, Tahsine Kosksi, Nawres Debbabi, Ghania Hamdi‐Degobert, Leila Chekir‐Ghedira   +6 more
wiley   +1 more source

L-DOPA neurotoxicity is mediated by up-regulation of DMT1-IRE expression.

PLoS ONE, 2009
BackgroundThe mechanisms underlying neurotoxicity caused by L-DOPA are not yet completely known. Based on recent findings, we speculated that the increased expression of divalent metal transporter 1 without iron-response element (DMT1-IRE) induced by L ...
Fang Du, Zhong-ming Qian, Li Zhu, Xiao Mei Wu, Wing-ho Yung, Ting-yuk Tsim, Ya Ke   +6 more
doaj   +1 more source

l-DOPA and Its Receptor GPR143: Implications for Pathogenesis and Therapy in Parkinson’s Disease

Frontiers in Pharmacology, 2019
l-3,4-Dihydroxyphenylalanine (l-DOPA) is the most effective therapeutic agent for Parkinson’s disease (PD). l-DOPA is traditionally believed to be an inert amino acid that exerts actions and effectiveness in PD through its conversion to dopamine.
Yoshio Goshima, Daiki Masukawa, Yuka Kasahara, Tatsuo Hashimoto, Aderemi Caleb Aladeokin   +4 more
doaj   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

Deuterium-L-DOPA : a novel means to improve treatment of Parkinson's disease

, 2012
L-DOPA, the precursor of dopamine, is administered to restore dopamine deficiency in Parkinson´s disease (PD) patients. L-DOPA initially provides a sustained symptomatic relief with superior efficacy as compared to other treatments, while long term ...
Torun Malmlof (18676393)
core   +1 more source