Results 81 to 90 of about 10,236,148 (357)

L-DOPA-induced signaling pathways and neuroepigenetic mechanisms in experimental parkinsonism and dyskinesia

, 2014
In patients with Parkinson’s disease (PD), the restoration of depleted striatal dopamine by chronic administration of its precursor, L-DOPA, results in the emergence of debilitating involuntary movements.
Michael Feyder (18637498)
core  

Temporal administration of entacapone with slow release L-dopa: pharmacokinetic profile and clinical outcome

, 2004
Entacapone is a specific, peripherally acting catechol- O-methyltransferase (COMT) inhibitor that prevents peripheral degradation of L-dopa, thus improving its bioavailability.
A. Bassi, PIERANTOZZI M., M. Pierantozzi, BRUSA L., LUNARDI G., Stanzione, P, Giacomini, P, FEDELE, ERNESTO, PIERANTOZZI, MARIANGELA, Fedele, E, G. Lunardi, Bassi, A, E. Fedele, GIACOBINI P., Lunardi, G, GIACOMINI, Patrizia, Pierantozzi, M, STANZIONE P., Brusa, L, P. Stanzione, BASSI A., STANZIONE, PAOLO, L. Brusa   +22 more
core   +1 more source

A Supramolecular Reversible and Anisotropic Conductive Adhesive for Flexible Electronics

Advanced Science, EarlyView.
Supramolecular network‐based nanocomposites are developed as a stretchable conductive adhesive for flexible electronics. It's as convenient as traditional solders and constructs anisotropic conductive and robust stretchable connections among diverse soft/rigid materials.
Tongtong Li, Yahui Zhao, Ying Zhang, Yuquan Li, Xuan Ye, Hongyun Qiu, Zhaorui Zhang, Jiang‐Fei Xu, Shaobo Ji   +8 more
wiley   +1 more source

L-DOPA administration improved symptoms and motor deficits of PD marmosets.

, 2018
(A) Cumulative PDRS scores of the marmosets during the on and off L-DOPA treatments. The parkinsonian marmosets (n = 3) showed improvement in PD disabilities following L-DOPA treatment (B) Motor subscale scores showing progression of individual ...
Marcel M. Daadi (40597), Gourav R. Choudhury (5680574)   +1 more
core   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

Changes in extracellular and intracellular L-DOPA concentration in methyl-L-DOPA-pretreated primary cultured striatal astrocytes after withdrawal of L-DOPA.

, 2014
Striatal astrocytes were treated with methyl-L-DOPA (200 µM) for 4 h or 8 h (filled bar). Furthermore, astrocytes pre-treated with methyl-L-DOPA for 8 h were incubated in fresh medium for 1 h or 4 h (gray bar).
Masato Asanuma (420841), Norio Ogawa (420846), Francisco J. Diaz-Corrales (420843), Shinki Murakami (564868), Ikuko Miyazaki (420842)   +4 more
core   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

Molecular basis of L-DOPA-induced dyskinesia : studies on striatal signaling

, 2009
Parkinson s disease (PD) is a neurological disorder characterized by tremor, rigidity and bradykinesia. PD is caused by selective degeneration of the dopaminergic neurons, which originate in the substantia nigra pars compacta (SNc) and project to the ...
Emanuela Santini (362343)
core  

Early diabetes‐like phenotypes in germ‐free mice induced by gut microbiota from patients with type 2 diabetes

Animal Models and Experimental Medicine, EarlyView.
Gut microbiota from patients with type 2 diabetes induced early diabetes‐like phenotypes in germ‐free mice, including progressive glucose intolerance and mild renal injury. Longitudinal profiling revealed persistent dysbiosis preceding stable metabolic dysfunction, with coordinated fecal and plasma metabolite alterations and a prominent L‐Dopa ...
Jianghao Feng, Xing Liu, Hua Zhu, Yun Yang, Wei Liu, Xiaoliang Jiang, Zhiwei Yang   +6 more
wiley   +1 more source

Injectable Bone Cements: A Generational Framework for Bioactivity, Porosity, and Mechanobiological Design at the Nanoscale

Advanced NanoBiomed Research, EarlyView.
Key demographic, biological, and material considerations that drive the need for advanced injectable bone cement technologies. Injectable bone cements (IBCs) are widely used in orthopaedic and craniofacial applications due to their minimally invasive delivery and ability to provide early mechanical stabilisation.
Frank Fei, Yogambha Ramaswamy, Young Jung No   +2 more
wiley   +1 more source