Results 171 to 180 of about 39,513 (265)

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

Quality assessment of "naturally occurring" high-percentage L-dopa commercial products proposed as dietary supplements on the Internet: from labeling to analytical findings. [PDF]

Front Chem
Aureli F, Gaudiano MC, Raimondo M, Maccelli A, Di Giorgio D, Gramazio M, Borioni A, Bartolomei M.   +7 more
europepmc   +1 more source

No Significant Secondary Structural Change of α‐Synuclein Monomer by Site‐Specific DOPA or Phosphorylation Introduction in Its C‐Terminal Region

Journal of Peptide Science, Volume 32, Issue 9, September 2026.
Site‐specifically modified α‐synuclein containing DOPA or phosphorylation was prepared by ligation of a bacterially expressed N‐terminal polypeptide and a synthetic C‐terminal modified peptide. ABSTRACT α‐Synuclein (αSyn) is a major component of pathogenic Lewy bodies and Lewy neurites and is closely associated with Parkinson's disease.
Tatsuhito Matsuo, Isao Suetake, Mariko Kimura, Satoshi Hashimoto, Koichi Matsuo, Sakiko Matsumoto, Shinji Hirotsune, Hironobu Hojo   +7 more
wiley   +1 more source

Striatal GluN2A gene suppression reduces L-DOPA-induced abnormal involuntary movements in parkinsonian rats. [PDF]

Neuropharmacology
Yabumoto T, Kochoian BA, Coletta S, Laur O, Huang X, Bure CA, Ware C, Jin P, Traynelis SF, Papa SM.   +9 more
europepmc   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, Volume 104, Issue 6, Page e630-e647, September 2026.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source

Enhanced catalytic stability for L-Dopa synthesis through cross-linking of Al₂O₃ nanocrystals with Bacillus subtilis tyrosine hydroxylase. [PDF]

World J Microbiol Biotechnol
Batool A, Ali S, Rashid A, Ahmad MU, Sana S, Campos LC.   +5 more
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Molecular and cellular determinants of L-Dopa-induced dyskinesia in Parkinson's Disease. [PDF]

NPJ Parkinsons Dis
Servillo F, De Carluccio M, Di Lazzaro G, Campanelli F, Marino G, Natale G, Ledonne A, Massaro Cenere M, Paldino E, Di Giuda D, Picca A, Bove F, Di Iorio R, Angeloni B, Cimmino AT, Bellomo G, Picconi B, Bentivoglio AR, Mercuri NB, Parnetti L, Ghiglieri V, Viscomi MT, Calabresi P.   +22 more
europepmc   +1 more source

Decoding chemical profiles in insect‐induced gall development: Insights from Phacopteron lentiginosum–Garuga pinnata interactions

Entomological Science, Volume 29, Issue 3, September 2026.
Analysis of volatile and non‐volatile metabolites across three developmental stages (3rd, 4th and 5th instar nymphal stages) of leaf galls induced by Phacopteron lentiginosum on Garuga pinnata revealed that the 3rd stage exhibited the highest chemical diversity and concentration followed by 4th and 5th stages.
V. K. Bobika, M. Nasser, K. S. Shameer
wiley   +1 more source

Abnormal arm swing movements in Parkinson's disease: onset, progression and response to L-Dopa. [PDF]

J Neuroeng Rehabil
Patera M, Zampogna A, Pietrosanti L, Asci F, Falletti M, Pinola G, Bianchini E, Di Lazzaro G, Rosati V, Grillo P, Giannini F, Fattapposta F, Costantini G, Pisani A, Saggio G, Suppa A.   +15 more
europepmc   +1 more source