Results 71 to 80 of about 10,236,148 (357)

Fluoxetine Improves the Effect of Levodopa on 6-Hydroxy Dopamine-Induced Motor Impairments in Rats [PDF]

Advanced Pharmaceutical Bulletin, 2012
Purpose: Long term L-DOPA therapy in Parkinson’s disease is associated with troublesome motor fluctuations such as L -DOPA Induced dyskinesia and wearing off effect.
Javad Mahmoudi, Alireza Mohajjel Nayebi, Siyamak Reyhani-Rad, Morteza Samini   +3 more
doaj  

Tetrabenazine Mitigates Aberrant Release and Clearance of Dopamine in the Nigrostriatal System, and Alleviates L-DOPA-Induced Dyskinesia in a Mouse Model of Parkinson’s Disease

Journal of Parkinson’s Disease, 2022
Background: L-DOPA-induced dyskinesia (LID), occurring with aberrant processing of exogenous L-DOPA in the dopamine-denervated striatum, is a main complication of levodopa treatment in Parkinson’s disease.
Kuan-Yin Tseng, Tung-Tai Kuo, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Lars Olson, Barry J. Hoffer, Yuan-Hao Chen   +7 more
doaj   +1 more source

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

Advanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr, Anne Schmitz, Meshkat Dinarvand, Franziska Wulfert, Sangeetha Shankar, Bjoern F. Hill, Michael Wojak, Juliana Gretz, Marie Britz, Elsa Neubert, Magdalena Shumanska, Sofia Kaushik, Linda Kartaschew, Ivan Bogeski, James Daniel, Sebastian Jung, Johannes Eble, Guido Wabnitz, Luise Erpenbeck, Sebastian Kruss   +19 more
wiley   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Intrastriatal inhibition of aromatic amino acid decarboxylase prevents l-DOPA-induced dyskinesia: A bilateral reverse in vivo microdialysis study in 6-hydroxydopamine lesioned rats

Neurobiology of Disease, 2008
l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia consists of involuntary choreiform and dystonic movements. Here we report whether intrastriatal l-DOPA itself is able to trigger dyskinetic behavior and which role the neurotransmitter dopamine (DA)
Kerstin Buck, Boris Ferger
doaj   +1 more source

O papel da dopamina no desenvolvimento de fadiga em modelo experimental de doença de Parkinson [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Desportos, Programa de Pós-Graduação em Educação Física, Florianópolis, 2013A doença de Parkinson (DP) é a segunda doença neurodegenerativa mais prevalente na população, com maior
Scheffer, Débora da Luz
core  

DOPA-based paclitaxel-loaded liposomes with modifications of transferrin and alendronate for bone and myeloma targeting

, 2016
Treatment for multiple myeloma (MM) with a combined strategy of bone and tumor targeting remains a crucial technical challenge due to the incorporation of various functional components into one single system. Here, we developed dioleoyl phosphatidic acid
Qing Chang (93814), Ding Qu (3222822), Rui Geng (3222825), Shanzheng Wang (3222819), Xiangfei Kong (1909192)   +4 more
core   +1 more source

Alpha and beta EEG power reflects L-dopa acute administration in parkinsonian patients [PDF]

, 2014
Aim: To evaluate the effect of an acute L-dopa administration on eye-closed resting state electroencephalographic (EEG) activity of cognitively preserved Parkinsonian patients.
Di Biase L, CURCIO, GIUSEPPE, Salomone G, Melgari J. M, Tombini M, Fabrizio E, Trotta L, Scrascia F, Rossini PM, Mastrolilli F, Vernieri F., Fini R   +11 more
core   +1 more source

Mass spectrometry imaging identifies abnormally elevated brain L-DOPA levels and extrastriatal monoaminergic dysregulation in L-DOPA-induced dyskinesia

, 2021
L-DOPA treatment for Parkinson's disease frequently leads to dyskinesias, the pathophysiology of which is poorly understood. We used MALDI-MSI to map the distribution of L-DOPA and monoaminergic pathways in brains of dyskinetic and nondyskinetic primates.
Crossman, Alan R., Fernagut, Pierre-Olivier,, Fridjonsdottir, Elva,, Vallianatou, Theodosia, Bezard, Erwan, Fernagut, Pierre-Olivier, Schembri, Luke, Bezard, Erwan,, Shariatgorji, Mohammadreza,, Schembri, Luke S, Andrén, Per, Nilsson, Anna,, Crossman, Alan R.,, Odell, Luke, Crossman, Alan, Svenningsson, Per, Andrén, Per E., Odell, Luke R.,, Fridjonsdottir, Elva, Andrén, Per E.,, Shariatgorji, Mohammadreza, Nilsson, Anna, Shariatgorji, Reza, Vallianatou, Theodosia,, Schembri, Luke S,, Svenningsson, Per,, Odell, Luke R.   +26 more
core   +1 more source

Bilateral SERS‐Microneedle Patch for Co‐Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity

Advanced Science, EarlyView.
Our study introduced a U@mP@Au‐mediated bilateral SERS‐microneedle patch for analyzing glucose levels from ISF and sensitively detecting TB biomarkers from sputum, respectively. This integrated dual‐analyte detecting platform can be used for co‐diagnosis of diabetes mellitus (DM) and tuberculosis (TB) comorbidity, which was demonstrated in ex vivo ...
Xueqin Huang, Lingzhi Chen, Jing Xu, Jiaqi Yu, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Lang Rao, Jierong Chen, Junxia Zheng, Haibo Zhou   +12 more
wiley   +1 more source