Results 121 to 130 of about 39,473 (264)

No New Relevant Treatment Options for L-DOPA-Induced Dyskinesia from a Clinician's Point of View. [PDF]

Neurol Int
Müller T.
europepmc   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

At the extreme limits of L-DOPA therapy: probable dopamine dysregulation and psychiatric complications in Parkinson's disease. [PDF]

BMJ Neurol Open
Oikarinen N, Ottela E, Rönkä J, Haanpää M, Niemelä S, Lees AJ, Kaasinen V.   +6 more
europepmc   +1 more source

Rotenone Induces Morphological Damage and Reduction in Catecholamine Levels in the Central Nervous System of the Ascidian Styela plicata

Environmental Toxicology, EarlyView.
ABSTRACT Ascidians are invertebrates that occupy a key phylogenetic position as a sister group of the vertebrates. The organization of their central nervous system (CNS), with cortex and medulla, indicates a plesiomorphic character of the gray and white matter of vertebrates, making this group of animals useful for studies of neurodegenerative events ...
Andressa de Abreu Mello, Carlos Augusto Borges de Andrade Gomes, Rafaela Rocha dos Santos, Cintia Monteiro de Barros, Silvana Allodi   +4 more
wiley   +1 more source

Disruption of the l-DOPA Receptor Gpr143/OA1-Gene in Mice Creates a Unique Mixed Psychosis-Like Phenotype. [PDF]

Neuropsychopharmacol Rep
Goshima Y, Nakamura H, Koga M, Koyama J, Kimura Y, Vasishth MN, Snyder EY, Asai M, Sakai K, Masukawa D.   +9 more
europepmc   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

l-DOPA-Containing Protein Autoxidation: An Empirical Valence Bond Simulation of the Rate-Limiting Step. [PDF]

J Phys Chem B
Oanca G, Prah A, Åqvist J, Mavri J.
europepmc   +1 more source

Conservative roots confer a larger microbial carbon pump efficacy than acquisitive roots by regulating microbial life‐history strategy

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Root activity creates unique microbial hotspots in the rhizosphere by influencing the metabolic activities of surrounding soil microorganisms, profoundly regulating the dynamics of soil organic carbon (SOC). However, how root economic strategies affect the formation and
Qiyu Tan, Peipei Zhang, Na Li, Guangru Wang, Wenbo Pang, Huangxin Zhang, Mingzhou Zhang, Qitong Wang, Huajun Yin   +8 more
wiley   +1 more source

Effects of chemogenetic inhibition of serotonergic raphe-striatal neurons on L-DOPA-induced behaviors and neurochemistry in a rat model of Parkinson's disease. [PDF]

Acta Neuropathol Commun
Budrow CN, Bernal-Conde LD, Sandoval IM, Galfano A, Grezenko H, Velazquez A, Marmion DJ, Flores-Barrera E, Venkatesh S, Coyle M, Meyers K, Nguyen K, Holden H, Tseng KY, Bishop CR, Manfredsson FP.   +15 more
europepmc   +1 more source

Elevated UV‐B alters anti‐herbivore plant defence allocation, while silicon supplementation maintains resistance

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract The impacts of elevated surface ultraviolet‐B (UV‐B) on ecological processes, such as anti‐herbivore defence in plants, remain poorly understood. Many cereal crops depend on accumulating silicon (Si) in their tissues to resist insect herbivory.
Sajjad Reyhani Haghighi, Christopher I. Cazzonelli, Sue E. Hartley, Scott N. Johnson   +3 more
wiley   +1 more source