Results 291 to 300 of about 10,236,148 (357)

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

Chirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz, Cigdem Karaaslan Kirmizioglu   +1 more
wiley   +1 more source

Intracerebroventricular anaerobic dopamine in Parkinson's disease with L-dopa-related complications: a phase 1/2 randomized-controlled trial. [PDF]

Nat Med
Moreau C, Odou P, Labreuche J, Demailly A, Touzet G, Reyns N, Gouges B, Duhamel A, Barthelemy C, Lannoy D, Carta N, Palas B, Vasseur M, Marchand F, Ollivier T, Leclercq C, Potey C, Ouk T, Baigne S, Dujardin K, Carton L, Rolland AS, Devedjian JC, Foutel V, Deplanque D, Fisichella M, Devos D.   +26 more
europepmc   +1 more source

Efficient Enantiomeric Selectivity Separation Via Homochiral Graphene Oxide Membrane

ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 4, July 2026.
A new type of chiral graphene oxide (GO) membrane is proposed that exhibits a separation factor of up to 20.1 as well as a preferential enantiomer flux of 4.5 mmol m−2 h−1. Moreover, the only first FPLC‐compatible column has been further developed via stacking these chiral GO membranes.
Junbo Wang, Jie Jiang, Weijie Yuan, Zonglin Gu, Fangfang Dai, Binquan Peng, Liuhua Mu, Yanwen Tan, Yusong Tu, Pei Li, Liang Chen   +10 more
wiley   +1 more source

Enhancements in morphology, biochemicals, nutrients, and L-Dopa in Faba bean through plant growth promoting rhizobacteria and arbuscular mycorrhizal Fungi. [PDF]

Sci Rep
Yilmaz H.
europepmc   +1 more source

L-DOPA Test in the Diagnosis of Childhood Short Stature: Evaluation of Growth Hormone Peaks Over Time. [PDF]

Endocrinol Diabetes Metab
Castelli B, De Santis R, Carrera S, Malanima MA, De Masi S, Stagi S.   +5 more
europepmc   +1 more source

Intrastriatal injection of alpha-synuclein preformed fibrils to rats results in L-DOPA reversible sensorimotor impairments and alterations in non-motor function. [PDF]

Front Neurosci
Fleming SM, Scott S, Hamad EJ, Herman DE, Holden JG, Yan L, Linning-Duffy K, Kemp CJ, Patterson JR, Miller KM, Kubik M, Kuhn N, Stoll AC, Duffy MF, Steece-Collier K, Cole-Strauss A, Lipton JW, Luk KC, Sortwell CE.   +18 more
europepmc   +1 more source

Enhancement of Haloperidol-Induced Catalepsy by GPR143, an l-DOPA Receptor, in Striatal Cholinergic Interneurons. [PDF]

J Neurosci
Hatzipantelis CJ.
europepmc   +1 more source

Antispastic effects of l-dopa

Experimental Brain Research, 1996
Antispastic effects of the noradrenaline and dopamine precursor l-3,4-dihydroxyphelanine (L-dopa) were investigated in 11 subjects in which exaggerated stretch reflexes developed after spinal cord injuries. The effects were evaluated from changes in the electromyographic (EMG) response of the quadriceps muscle during tendon jerks evoked by standardized
J, Eriksson, B, Olausson, E, Jankowska
openaire   +3 more sources

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L-Dopa and Oligozoospermia

Andrologia, 2009
A clinical investigation of L-Dopa on idiopathic oligozoospermia is carried out. Thirty nine male oligozoospermic patients with primary sterility were divided in two groups. The first group of 25 patients was treated with 500 mg a day during two months. The second group of 14 patients received 750 mg a day for the same time.
J C, Lavieri, A A, Pierini
openaire   +2 more sources

L-Dopa and Parkinsonism

Nature, 1970
This new treatment for an old disease has its origins in pharmacological research of the late 1950s. There is still not full agreement about how L-dopa functions in the nervous system, but, as this review shows, there is ample evidence to support the clinical work in progress since 1961.
D B, Calne, M, Sandler
openaire   +2 more sources