Results 181 to 190 of about 24,681,778 (305)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Umpolung Character of Styrenes: Mechanism and Stereoselective Studies of α, β-Substituted Amino Acids Using Chiral Ir-Phosphine Complexes. [PDF]

J Comput Chem
Bhaskararao B, Antonio JJ, Kraka E.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

AOFT Field Structures of the TCV L–H Transition

We present a compact, data-driven visualisation of organisational dynamics during the TCV L–H transition using the Alpha–Omega Field Theory (AOFT). The effective organisational frequency f(t) = \frac{1}{2\pi}\sqrt{P_{\mathrm{heat}}(t)/W_{\mathrm{MHD}}(t)} is computed directly from experimental heating-power and stored-energy time series of a ...
openaire   +2 more sources

Static and Dynamic Responses of One-Dimensional Hexagonal Piezoelectric Quasicrystal Microbeams Resting on Elastic Foundations. [PDF]

Materials (Basel)
Zhang S, Zhang L, Li L, Liu B.
europepmc   +1 more source

Rapid Change of Hydrogen Neutral Energy Distribution at L/H-Transition in JFT-2M H-mode

"Rapid changes of the main ion energy distribution at transitions from L-to-H, H-to-L and during ELMs are studied with the time of flight neutral measurement on the JFT-2M tokamak.
JFT-2M, Group, "Miura, Y., Hoshino, K., Maeda, H., Itoh, K.", Itoh, S.-I., Takizuka, T., Okano, F., Mori, M., Suzuki, N.   +9 more
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Statement of Retraction: β-Patchoulene represses hypoxia-induced proliferation and epithelial-mesenchymal transition of liver cancer cells. [PDF]

Bioengineered
europepmc   +1 more source

Reversible layered/non-layered phase transition in a topological semimetal. [PDF]

Nat Commun
Liang Q, Chen J, Xie Z, Shi X, Yang L, Jiang W, Zhou J, Zheng S.   +7 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source