Results 211 to 220 of about 12,924,254 (307)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Single-mode tuneable laser operation of hybrid microcavities based on CdSe/CdS core/shell colloidal nanorods on silica microspheres

Colloidal core/shell semiconductor nanonorystals have generated a great deal of interest as gain media in recent years due to a number of salient properties originating from their small size and the associated quantum confinement [1].
Ding, M., Andreakou, P., Manna, L., Grivas, C., Brambilla, G., Wang, Pengfei, Lagoudakis, P.G.   +6 more
core  

High-purity linearly polarized emission from a compact BIC laser. [PDF]

Light Sci Appl
Li Y, Guo W, Cui Z, Liang G, Li Z, Zheng G, Tao J, Deng ZL, Yu S, Zeng Y.   +9 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Polarization mode dispersion reduction in spun silica holey fibres

We report the fabrication of a spun holey optical fibre. Our experiments show that the complex air/glass transverse structure can be retained when the preform is spun during the fibre drawing process.
Petrovich, M.N., Fuochi, M., Baggett, J.C., Richardson, D.J., Monro, T.M., Hayes, J.R.   +5 more
core  

Interaction driven artificial magnetic conductor and defected ground structure integrated microstrip antenna for subsurface communication. [PDF]

Sci Rep
Halder S, Ghosh A, Bordoloi S, Chattopadhyay S.   +3 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Juice turbidity and fermentation method: key drivers of aroma complexity in Italian Riesling grape spirit production. [PDF]

Food Chem X
Wang H, Bi J, Liu G, Gao T, Bai W, Liang Y, Song Y, Qin Y.   +7 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Etiological Spectrum and Maternal Peripartum Hematologic Outcomes of Thrombocytopenia in Pregnancy: A Retrospective Cohort Study. [PDF]

Medicina (Kaunas)
Erbey B, Atalay CR, Erbey S.
europepmc   +1 more source