Results 121 to 130 of about 295,403 (308)
Statistical L-moment and L-moment Ratio Estimation and their Applicability in Network Analysis
, 2019 This research centers on finding the statistical moments, network measures, and statistical tests that are most sensitive to various node degradations for the Barabási-Albert, Erdös-Rényi, and Watts-Strogratz network models.
Anderson, Timothy S.
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
, 2008 : The L-moment estimation method is applied to the parameters of a Log-Normal distribution. Two sample formulae of L-moments, considering historical floods are proposed.
Gu Sheng-hua +4 more
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Ankara’da meydana gelen yağmurların L moment yöntemleri ile bölgesel frekans analizi
, 2009 Bu araştırmada Ankara ilinde meydana gelen yağmurların L moment yöntemleri ile noktasal ve bölgesel frekans analizi gerçekleştirilmiştir. Bu amaçla öncelikle Ankara ilinde bulunan 32 yağış gözlem istasyonundan elde edilen günlük yağmur miktarlarından ...
Anlı, Alper Serdar
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2019 The design of hydraulic structures and the assessment of flood control measures require the estimation of flood quantiles. Since observed flood data are rarely available at the specific location, flood estimation in un-gauged or poorly gauged basins is a
Do-Hun Lee, Nam Won Kim
core +1 more source
Constraints on ∆L = 2 vector bosons with tree couplings to SM particles
Journal of High Energy PhysicsWe investigate phenomenological implications of vector bosons V transforming as (1, 2, -3/2) under the standard model (SM) product gauge group SU(3) C , SU(2) L and U(1) Y . These vector bosons can couple to two SM leptons at tree-level forming dimension-
Zhong-Lv Huang, Xiao-Gang He
doaj +1 more source