Results 141 to 150 of about 295,403 (308)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
, 2019 The focus of this research was to design a simple to use Microsoft excel algorithm that will aid in the estimation of the parameters of generalized extreme value probability distribution (GEV), generalized logistics probability distribution (GLO) and ...
Ilaboya, Idowu Rudolph
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2013 The analysis and use of hydrological data for decision making in water resources planning and management can only be meani ngful if the data possess the appropriate characteristics.
Babak Amirataee, Majid Montaseri
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Decoupling neutrino magnetic moment from mass with $$SU(2)_L$$ S U ( 2 ) L invariance
European Physical Journal C: Particles and FieldsStandard Model extensions that yield observable neutrino magnetic moments typically also induce large neutrino masses, incompatible with experimental limits.
Julie Pagès, Anil Thapa
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Modeling of Annual Maximum Storm Intensity with Bayesian Markov Chain Monte Carlo (MCMC) and L-moment [PDF]
This study presents the best fitting distribution to describe the siries MSI based on hourly rainfall form 1970 to 2008 for three rain gauge stations in Peninsular Malaysia namely Bertam, Dungun and Pekan.
Rado Yendra, - +5 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
L-moment-based frequency analysis of high-flow at Sungai Langat, Kajang, Selangor, Malaysia
, 2019 Annual maximum daily streamflow data were used to examine flood frequency for Sungai Langat in Kajang, Selangor, Malaysia. The objectives of this study were to identify the best fit probability distribution to the streamflow data and estimate the return ...
Jawatankuasa Kerja PSM UKM
core