Results 161 to 170 of about 295,403 (308)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Estimating non-stationary extreme-value probability distribution shifts and their parameters under climate change using L-moments and L-moment ratio diagrams: A case study of hydrologic drought in the Goat River near Creston, British Columbia

Here, we investigate the use of rolling-windowed L-moments (RWLMs) and L-moment ratio diagrams (LMRDs) combined with a Multiple Linear Regression (MLR) machine learning algorithm to model non-stationary low-flow hydrological extremes with the potential ...
Isaac Dekker, Pearce Jones, Dubrawski Kristian L., MacDonald, Ryan, Kristian Dubrawski, Dekker, Isaac, Jones, Pearce, Ryan MacDonald   +7 more
core   +1 more source

Giant magnetic moment increase by ultrafast laser light. [PDF]

Nat Commun
Sharma S, Gill D, Krishna J, Harris-Lee E, Dewhurst JK, Shallcross S.   +5 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Electric Field Effects on the Optoelectronic Properties of Fluorinated Heptyl-Bicyclohexyl-Biphenyl: A TD-DFT Investigation. [PDF]

ACS Omega
Trabelsi J, Esboui M.
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Numerical Modeling of RC Beams Strengthened with Non-Pretensioned and Pretensioned NSM CFRP Strips. [PDF]

Materials (Basel)
Seręga S, Kotynia R.
europepmc   +1 more source

Generalizations and Applications of L-moments

International Journal of Business and Statistical Analysis, 2016
openaire   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Gait in childhood and adulthood in persons with myelomeningocele - a retrospective analysis. [PDF]

BMC Neurol
Eriksson M, Gutierrez-Farewik EM, Bartonek Å.   +2 more
europepmc   +1 more source