Results 271 to 280 of about 729,292 (310)

Blood pressure variability in established L-NAME hypertension in rats

Journal of Hypertension, 1999
Blood pressure variability was evaluated in conscious Wistar control rats and rats with established L-NAME hypertension (20 mg/kg per 24 h, 4 weeks).Final systolic arterial pressure was 185+/-5 and 132+/-4 mm Hg in the Nomega-nitro-L-arginine methyl ester (L-NAME)-treated and control rats, respectively.
J, Blanc, P, Ponchon, D, Laude, J L, Elghozi, B, Jover   +4 more
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Mibefradil prevents L-NAME-exacerbated nephrosclerosis in spontaneously hypertensive rats

Journal of Hypertension, 1999
To determine the potential renal protective effects of a novel calcium channel blocker mibefradil in chronic renal failure.We compared the long-term effects of mibefradil with an angiotensin-converting enzyme inhibitor cilazapril on blood pressure, proteinuria, renal function and histological alterations in N-nitro-L-arginine methylester (L-NAME ...
C, Qiu, P, Bruneval, A, Roeckel, D, Heudes, J P, Duong Van Huyen, S, Roux   +5 more
openaire   +2 more sources

L-NAME enhances pulmonary vasoconstriction without inhibiting EDRF-dependent vasodilation

Journal of Applied Physiology, 1992
The purpose of the present study was to determine the influence of NG-nitro-L-arginine methyl ester (L-NAME) on pulmonary vascular responses to endothelium-dependent relaxing factor- (EDRF) dependent and EDRF-independent substances in the pulmonary vascular bed of the anesthetized cat.
H L, Lippton, Q, Hao, A, Hyman
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Hypothalamic and Plasmatic Angiotensin Metabolism in L-NAME Treated Rats

Hormone and Metabolic Research, 2010
In order to study the interaction between the renin-angiotensin system (RAS) and nitric oxide (NO), we analyzed the activity of aspartyl- (AspAP), glutamyl- (GluAP), alanyl- (AlaAP), and cystinylaminopeptidase (CysAP) enzymes involved in the RAS cascade, in the hypothalamus, and plasma of normotensive adult male rats after the inhibition of NO ...
A B, Segarra, M, Ramírez, A B, Villarejo, I, Banegas, F, Vives, M, de Gasparo, F, Alba, J, Cobo, I, Prieto   +8 more
openaire   +2 more sources

L-NAME in the cardiovascular system – nitric oxide synthase activator?

Pharmacological Reports, 2012
L-arginine analogues are widely used inhibitors of nitric oxide synthase (NOS) activity both in vitro and in vivo, with N(ω)-nitro-L-arginine methyl ester (L-NAME) being at the head. On the one hand, acute and chronic L-NAME treatment leads to changes in blood pressure and vascular reactivity due to decreased nitric oxide (NO) bioavailability. However,
Jana, Kopincová, Angelika, Púzserová, Iveta, Bernátová   +2 more
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The nitric oxide synthesis inhibitor L-name facilitates associative learning

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1996
1. Nitric oxide has been suggested to play an important role in synaptic plasticity and in learning. 2. The authors examined the effects of NW-nitro-L-arginine methyl ester, a competitive and enantiomeric specific inhibitor of nitric oxide synthase, on classical conditioning of the rabbit's nictitating membrane response. 3.
W, Du, J A, Harvey
openaire   +2 more sources

Effect of low dose L-NAME pretreatment on nitric oxide/reactive oxygen species balance and vasoactivity in L-NAME/salt-induced hypertensive rats.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2019
Nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase-dependent reactive oxygen species (ROS) overproduction and decreased nitric oxide (NO) bioavailability lead to vascular dysfunction and development of hypertension. The goal of our study was to analyze an effect of salt diet and NO synthase (NOS) inhibition with NG-nitro-L-arginine ...
S, Vrankova, A, Zemancikova, J, Torok, O, Pechanova   +3 more
openaire   +2 more sources

Egzersizin L-NAME hipertansiyonuna etkisi

2020
78
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Dose-Dependent Autonomic Dysfunction in Chronic L-NAME-Hypertensive Diabetic Rats

Journal of Cardiovascular Pharmacology, 2005
This study investigated the effects of varying doses of L-NAME on arterial pressure (AP), baroreflex control, and heart rate (HR)/AP variability in the STZ-diabetic rat. Fifty-two male Wistar rats were injected with 50 mg/kg IV STZ (diabetes, D, n = 24) or citrate (controls, C, n = 28) 30 days before recordings.
Adriana Werner, Balbinott, Maria Claudia, Irigoyen, Maria do Socorro, Brasileiro-Santos, Berenice, Zottis, Nelson Gianni, de Lima, Juliana, Passaglia, Beatriz D'Agord, Schaan   +6 more
openaire   +2 more sources

L-NAME-induced heavy proteinuria in healthy rats

Doklady Biological Sciences, 2010
A V, Kutina, V V, Zakharov, E I, Shahmatova, Yu V, Natochin   +3 more
openaire   +2 more sources