Results 1 to 10 of about 7,513 (165)

RETRACTED: Neuroprotective Role of L-NG-Nitroarginine Methyl Ester (L-NAME) against Chronic Hypobaric Hypoxia with Crowding Stress (CHC) Induced Depression-Like Behaviour.

PLoS ONE, 2016
Improper neuroimmune responses following chronic stress exposure have been reported to cause neuronal dysfunctions leading to memory impairment, anxiety and depression like behaviours. Though several factors affecting microglial activation and consequent
Satya Narayan Deep, Iswar Baitharu, Apurva Sharma, Anoop Kishor Singh Gurjar, Dipti Prasad, Shashi Bala Singh   +5 more
doaj   +6 more sources

Effects of Diclofenac, L-NAME, L-Arginine, and Pentadecapeptide BPC 157 on Gastrointestinal, Liver, and Brain Lesions, Failed Anastomosis, and Intestinal Adaptation Deterioration in 24 Hour-Short-Bowel Rats. [PDF]

PLoS ONE, 2016
Stable gastric pentadecapeptide BPC 157 was previously used to ameliorate wound healing following major surgery and counteract diclofenac toxicity. To resolve the increasing early risks following major massive small bowel resectioning surgery, diclofenac
Nermin Lojo, Zarko Rasic, Anita Zenko Sever, Danijela Kolenc, Darko Vukusic, Domagoj Drmic, Ivan Zoricic, Marko Sever, Sven Seiwerth, Predrag Sikiric   +9 more
doaj   +5 more sources

Physalis angulata leaf extract ameliorates L-NG-nitroarginine methyl ester (L-NAME)-induced preeclampsia symptoms in rats through improved endothelial progenitor cells and endothelial cells due to reduced antiangiogenic factor and oxidative stress

F1000Research, 2022
Background: This study aimed to determine the ameliorative effects of Physalis angulata leaf extract on L-NG-nitroarginine methyl ester (L-NAME)-induced preeclampsia symptoms in rats. Methods: Phytochemical analysis of the extract was performed with liquid chromatography-high resolution mass spectrometry (LC-HRMS).
Dian Nugrahenny, Achmad Rudijanto, Nur Permatasari, I Wayan Arsana Wiyasa, Mohammad Aris Widodo, Karyono Mintaroem, Edi Widjajanto, Mustofa Mustofa   +7 more
semanticscholar   +3 more sources

Tadalafil Improves L-NG-Nitroarginine Methyl Ester-Induced Preeclampsia With Fetal Growth Restriction-Like Symptoms in Pregnant Mice [PDF]

American Journal of Hypertension, 2017
Abstract BACKGROUND We investigated the efficacy and mechanisms of tadalafil, a selective phosphodiesterase 5 inhibitor, in treating preeclampsia (PE) with fetal growth restriction (FGR) using L-NG-nitroarginine methyl ester (L-NAME)-induced PE with FGR in pregnant mice as our experimental model.
Kento, Yoshikawa, Takashi, Umekawa, Shintaro, Maki, Michiko, Kubo, Masafumi, Nii, Kayo, Tanaka, Hiroaki, Tanaka, Kazuhiro, Osato, Yuki, Kamimoto, Eiji, Kondo, Kenji, Ikemura, Masahiro, Okuda, Kan, Katayama, Takekazu, Miyoshi, Hiroshi, Hosoda, Ning, Ma, Toshimichi, Yoshida, Tomoaki, Ikeda   +17 more
openaire   +3 more sources

Effects of nitric oxide synthase inhibitors, l‐N^G‐nitroarginine and l‐N^G‐nitroarginine methyl ester, on responses to vasodilators of the guinea‐pig coronary vasculature [PDF]

British Journal of Pharmacology, 1992
The effects of l‐NG‐nitroarginine (l‐NOARG) and l‐NG‐nitroarginine methyl ester (l‐NAME) on vasodilatation induced by ATP, substance P, 5‐hydroxytryptamine (5‐HT), bradykinin and sodium nitroprusside (SNP) were examined in the guinea‐pig coronary bed, by use of a Langendorff technique.
A, Vials, G, Burnstock
openaire   +3 more sources

Combination of angiotensin II andl-N^G-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure [PDF]

American Journal of Physiology-Heart and Circulatory Physiology, 2016
Mitochondrial dysfunction has been implicated as a cause of energy deprivation in heart failure (HF). Herein, we tested individual and combined effects of two pathogenic factors of nonischemic HF, inhibition of nitric oxide synthesis [with l- NG-nitroarginine methyl ester (l-NAME)] and hypertension [with angiotensin II (AngII)], on myocardial ...
Dale J, Hamilton, Aijun, Zhang, Shumin, Li, Tram N, Cao, Jessie A, Smith, Indira, Vedula, Andrea M, Cordero-Reyes, Keith A, Youker, Guillermo, Torre-Amione, Anisha A, Gupte   +9 more
openaire   +3 more sources

The Possible Anti-nociceptive Effect of Troxerutin and Neural Interactions Using Formalin and Writhing Tests in Mice [PDF]

Avicenna Journal of Medical Biochemistry, 2023
Background: Previous reports suggest flavonoids as potent analgesic compounds. Objectives: Based on these observations, the present study investigated the anti-nociceptive action of troxerutin and neural interactions with opioidergic, serotoninergic ...
Farima Jafari-Tirabadi, Shahin Hassanpour, Ahmad Asghari   +2 more
doaj   +2 more sources

Physalis angulata Leaf Ethanol Extract Reduces Oxidative Stress and Improves Endothelial Progenitor Cells in L-NAME-Induced Hypertensive Rats [PDF]

Hayati Journal of Biosciences, 2022
This study aimed to evaluate the effects of ciplukan (Physalis angulata L.) leaf ethanol extract on L-NG-nitroarginine methyl ester (L-NAME)-induced hypertensive rats. We randomly divided twenty-five Wistar rats into five groups.
Dian Nugrahenny, Nur Permatasari, Setyawati Soeharto, Indriati Dwi Rahayu, Edwin Widodo, Karyono Mintaroem, Hidayat Sujuti, Retty Ratnawati, Elly Mayangsari, Dicky Faizal Irnandi, Lavina Sofia Ardani, Tika Ardhini Wardoyo, Nathania Bella Claresta, Nura Fattah Cantika Yoga, Adinda Chika Anindita, Niarti Ulan Sari Siarnu, Fardizia Putri Alia   +16 more
doaj   +3 more sources

N-Acetylcysteine and N-Nitroarginine Methyl Ester Attenuate Carboplatin-Induced Ototoxicity in Dissociated Spiral Ganglion Neuron Cultures

Clinical and Experimental Otorhinolaryngology, 2011
Objectives Carboplatin, a platinum-containing anti-cancer drug used to treat a variety of cancers, induces ototoxicity. Since, reactive oxygen species (ROS) and nitric oxide (NO) seem to be responsible for this toxicity, the antioxidant, N-acetyl-L ...
Il Joon Moon
exaly   +2 more sources

Role of HO/CO in the Control of Peripheral Circulation in Humans [PDF]

International Journal of Hypertension, 2012
Experimental studies show that the heme oxygenase/carbon monoxide system (HO/CO) plays an important role in the homeostasis of circulation and in the pathophysiology of hypertension.
David Sacerdoti, Despina Mania, Paola Pesce, Silvia Gaiani, Angelo Gatta, Massimo Bolognesi   +5 more
doaj   +4 more sources