Results 11 to 20 of about 7,513 (165)

Identification of ageing-associated gene signatures in heart failure with preserved ejection fraction by integrated bioinformatics analysis and machine learning

Genes and Diseases
The incidence of heart failure with preserved ejection fraction (HFpEF) increases with the ageing of populations. This study aimed to explore ageing-associated gene signatures in HFpEF to develop new diagnostic biomarkers and provide new insights into ...
Guoxing Li, Qingju Zhou, Ming Xie, Boying Zhao, Keyu Zhang, Yuan Luo, Lingwen Kong, Diansa Gao, Yongzheng Guo   +8 more
doaj   +2 more sources

Divergent cardiac and renal effects of miR-181c-5p inhibition in a rodent heart failure model

Frontiers in Cardiovascular Medicine
AimsMiR-181c-5p overexpression associates with heart failure (HF) and cardiac damage, but the underlying pathophysiology remains unclear. This study investigated the effect of miR-181c-5p inhibition on cardiac function and fibrosis in a rodent model of ...
Jente R. A. Boen, Jente R. A. Boen, Andreas B. Gevaert, Andreas B. Gevaert, Amélie Dendooven, Amélie Dendooven, Dustin Krüger, Michiel Tubeeckx, Jens Van Fraeyenhove, Tine Bruyns, Vincent F. M. Segers, Vincent F. M. Segers, Emeline M. Van Craenenbroeck, Emeline M. Van Craenenbroeck   +13 more
doaj   +2 more sources

Isosakuranetin ameliorates hypertension in rats induced by L-NAME

Journal of Pharmaceutical Health Care and Sciences
Background Hypertension is a major global health problem that often develops without noticeable symptoms. Current treatments and complementary approaches focus on improving endothelial function and enhancing nitric oxide (NO) production to promote ...
Rungusa Pantan, Ratchanaporn Chokchaisiri, Apichart Suksamrarn, Chainarong Tocharus   +3 more
doaj   +2 more sources

Metabolomic Profiling and Biological Investigation of the Marine Sponge-Derived Fungus Aspergillus sp. SYPUF29 in Response to NO Condition

Journal of Fungi
Marine-derived fungi are assuming an increasingly central role in the search for natural leading compounds with unique chemical structures and diverse pharmacological properties.
Jiao Xiao, Xiuping Lin, Yanqiu Yang, Yingshu Yu, Yinyin Li, Mengjie Xu, Yonghong Liu   +6 more
doaj   +2 more sources

Dioscorea prehensilis Ameliorates the Features of Preeclampsia in L-NG-Nitroarginine Methyl Ester (L-NAME) Preeclamptic Model

Tropical Journal of Natural Product Research, 2018
Iyabo Adebisi, Shaibu Bello, Constance Shehu, Musa Abdullahi, Chinenye Ugwah-Oguejiofor, Nnaemeka Ndodo, Mohammed Umar   +6 more
openaire   +2 more sources

Perinatal N(G)-Nitro-L-arginine methyl ester administration decreases anxiety- and depression-like behaviors in adult mice [PDF]

Einstein (São Paulo), 2023
Objective: We hypothesized that perinatal manipulations of the nitrergic system would affect adult animal behaviors. Methods: We tested this hypothesis by perinatally administering N(G)-Nitro-L-arginine methyl ester (L-NAME), a non-specific antagonist ...
Raoni Conceição Dos-Santos, Cláudio da Silva-Almeida, Bruno Guimarães Marinho, Rodrigo Rodrigues da Conceição, Wellington da Silva Côrtes, Ragab Gaber Ahmed, Roberto Laureano-Melo   +6 more
doaj   +1 more source

Effects of oxidative stress on liver, brain and spinal cord of rats using L-NAME and treated with hydroxyurea. A model of sickle cell complication [PDF]

Acta Cirúrgica Brasileira, 2020
Purpose: To analyze the serum levels of nitric oxide and correlate them with the levels of thiobarbituric acid reactive substances (TBARS) in liver, brain and spinal cord of animals using L-NAME and treated with hydroxyurea.
Abilio Torres dos Santos Neto, Iandara Schettert Silva, Maria Lucia Ivo, Camila Tozaki Rodrigues, Eduardo Benedetti Parisotto, Rondon Tosta Ramalho, Geanlucas Mendes Monteiro   +6 more
doaj   +1 more source

Effects of L-arginine and L-NAME on ischemia-reperfusion in rat liver [PDF]

Acta Cirúrgica Brasileira, 2015
PURPOSE: To evaluated the effects of L-arginine (a NO donor) and L-NAME (Nw-nitro-L-arginine methyl ester - a NOS inhibitor) on ischemia-reperfusion in rat livers.METHODS: One hundred fifty two male Wistar rats were divided into four groups: control ...
Márcio Luís Lucas, Cláudia Ramos Rhoden, Ernani Luís Rhoden, Cláudio Galeano Zettler, Angelo Alves de Mattos   +4 more
doaj   +1 more source

Novel enhancers of guanylyl cyclase‐A activity acting via allosteric modulation

British Journal of Pharmacology, Volume 180, Issue 24, Page 3254-3270, December 2023., 2023
Abstract Background and Purpose Guanylyl cyclase‐A (GC‐A), activated by endogenous atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), plays an important role in the regulation of cardiovascular and renal homeostasis and is an attractive drug target. Even though small molecule modulators allow oral administration and longer half‐life,
Henriette Andresen, Cristina Pérez‐Ternero, Jerid Robinson, Deborah M. Dickey, Adrian J. Hobbs, Lincoln R. Potter, Finn Olav Levy, Alessandro Cataliotti, Lise Román Moltzau   +8 more
wiley   +1 more source

CNS sites controlling the gastric pyloric sphincter: Neuroanatomical and functional study in the rat

Journal of Comparative Neurology, Volume 531, Issue 15, Page 1562-1581, October 2023., 2023
The dorsal motor nucleus of the vagus (DMV) of the brainstem is a crucial region that modulates the activity of gastric function. The pyloric sphincter at the gastroduodenal junction, which regulates the flow of partially digested food from the stomach, is mediated by the nucleus in a site‐specific manner.
Janell Richardson, Ghazaul Dezfuli, Allen W. Mangel, Richard A. Gillis, Stefano Vicini, Niaz Sahibzada   +5 more
wiley   +1 more source