Results 11 to 20 of about 1,078,448 (173)

Tadalafil Improves L-NG-Nitroarginine Methyl Ester-Induced Preeclampsia With Fetal Growth Restriction-Like Symptoms in Pregnant Mice [PDF]

American Journal of Hypertension, 2017
Abstract BACKGROUND We investigated the efficacy and mechanisms of tadalafil, a selective phosphodiesterase 5 inhibitor, in treating preeclampsia (PE) with fetal growth restriction (FGR) using L-NG-nitroarginine methyl ester (L-NAME)-induced PE with FGR in pregnant mice as our experimental model.
Kento, Yoshikawa, Takashi, Umekawa, Shintaro, Maki, Michiko, Kubo, Masafumi, Nii, Kayo, Tanaka, Hiroaki, Tanaka, Kazuhiro, Osato, Yuki, Kamimoto, Eiji, Kondo, Kenji, Ikemura, Masahiro, Okuda, Kan, Katayama, Takekazu, Miyoshi, Hiroshi, Hosoda, Ning, Ma, Toshimichi, Yoshida, Tomoaki, Ikeda   +17 more
openaire   +3 more sources

Alterations of myocardial ketone metabolism in heart failure with preserved ejection fraction (HFpEF). [PDF]

ESC Heart Fail
Abstract Introduction Cardiac energy metabolism is disrupted in heart failure with preserved ejection fraction (HFpEF), as characterized by a switch from glucose oxidation towards fatty acid oxidation. However, although oxidation of ketones is an important source of ATP it remains unclear how the heart oxidizes ketones in HFpEF.
Sun Q, Wagg CS, Wong N, Wei K, Ketema EB, Zhang L, Fang L, Seubert JM, Lopaschuk GD.   +8 more
europepmc   +2 more sources

Effects of nitric oxide synthase inhibitors, l‐N^G‐nitroarginine and l‐N^G‐nitroarginine methyl ester, on responses to vasodilators of the guinea‐pig coronary vasculature [PDF]

British Journal of Pharmacology, 1992
The effects of l‐NG‐nitroarginine (l‐NOARG) and l‐NG‐nitroarginine methyl ester (l‐NAME) on vasodilatation induced by ATP, substance P, 5‐hydroxytryptamine (5‐HT), bradykinin and sodium nitroprusside (SNP) were examined in the guinea‐pig coronary bed, by use of a Langendorff technique.
A, Vials, G, Burnstock
openaire   +2 more sources

Combination of angiotensin II andl-N^G-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure [PDF]

American Journal of Physiology-Heart and Circulatory Physiology, 2016
Mitochondrial dysfunction has been implicated as a cause of energy deprivation in heart failure (HF). Herein, we tested individual and combined effects of two pathogenic factors of nonischemic HF, inhibition of nitric oxide synthesis [with l- NG-nitroarginine methyl ester (l-NAME)] and hypertension [with angiotensin II (AngII)], on myocardial ...
Dale J, Hamilton, Aijun, Zhang, Shumin, Li, Tram N, Cao, Jessie A, Smith, Indira, Vedula, Andrea M, Cordero-Reyes, Keith A, Youker, Guillermo, Torre-Amione, Anisha A, Gupte   +9 more
openaire   +2 more sources

Novel enhancers of guanylyl cyclase‐A activity acting via allosteric modulation

British Journal of Pharmacology, Volume 180, Issue 24, Page 3254-3270, December 2023., 2023
Abstract Background and Purpose Guanylyl cyclase‐A (GC‐A), activated by endogenous atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), plays an important role in the regulation of cardiovascular and renal homeostasis and is an attractive drug target. Even though small molecule modulators allow oral administration and longer half‐life,
Henriette Andresen, Cristina Pérez‐Ternero, Jerid Robinson, Deborah M. Dickey, Adrian J. Hobbs, Lincoln R. Potter, Finn Olav Levy, Alessandro Cataliotti, Lise Román Moltzau   +8 more
wiley   +1 more source

Growing season methyl bromide and methyl chloride fluxes at a sub-arctic wetland in Sweden [PDF]

, 2009
Methyl bromide and methyl chloride fluxes were measured at several sites in a sub-arctic wetland near Abisko, Sweden (68°280N 18°490E) throughout the 2008 growing season.
Blei, Emanuel, Heal, Mathew R., Hardacre, Catherine   +2 more
core   +5 more sources

CNS sites controlling the gastric pyloric sphincter: Neuroanatomical and functional study in the rat

Journal of Comparative Neurology, Volume 531, Issue 15, Page 1562-1581, October 2023., 2023
The dorsal motor nucleus of the vagus (DMV) of the brainstem is a crucial region that modulates the activity of gastric function. The pyloric sphincter at the gastroduodenal junction, which regulates the flow of partially digested food from the stomach, is mediated by the nucleus in a site‐specific manner.
Janell Richardson, Ghazaul Dezfuli, Allen W. Mangel, Richard A. Gillis, Stefano Vicini, Niaz Sahibzada   +5 more
wiley   +1 more source

Extracellular vesicles derived from Akkermansia muciniphila promote placentation and mitigate preeclampsia in a mouse model

Journal of Extracellular Vesicles, Volume 12, Issue 5, May 2023., 2023
Am produced EVs in the GI tract. AmEVs can cross the intestinal barrier and reach the placenta in dams. AmEVs can interact with trophoblasts to improve trophoblast proliferation, migration and invasion by activating the EGFR‐PI3K‐AKT signalling pathway, which further promotes SpA remodelling. The graphical abstract was created with BioRender.com.
Yun Chen, Zihao Ou, Menglan Pang, Zixin Tao, Xifen Zheng, Zhipeng Huang, Dongni Wen, Qianbei Li, Ruisi Zhou, Peng Chen, Bo Situ, Chao Sheng, Yingying Huang, Xiaojing Yue, Lei Zheng, Liping Huang   +15 more
wiley   +1 more source

Critical role of mitogen‐inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis

Journal of Cell Communication and Signaling, Volume 17, Issue 1, Page 151-165, March 2023., 2023
Graphical abstract Xing et al. (2022) investigated the critical role of MIG6 in vascular permeability. MIG6 deficiency promotes VEGFA‐induced vascular permeability via activation of PLCγ1‐Ca2+‐eNOS signaling and perturbation of the balance in RAC1/RHOA activation, resulting in endothelial barrier disruption.
Liying Xing, Guanqun Huang, Rongyuan Chen, Lijuan Huang, Juanxi Liu, Xiangrong Ren, Shasha Wang, Haiqing Kuang, Anil Kumar, Jong Kyong Kim, Qin Jiang, Xuri Li, Chunsik Lee   +12 more
wiley   +1 more source

The effect of L-arginine and L-NAME on myocardial capillary density in normal rats

Advanced Biomedical Research, 2013
Background: This study evaluated the effect of L-arginine (Nitric Oxide (NO) precursor) and L-NG-Nitroarginine Methyl Ester (L-NAME) (NO synthase inhibitor) on myocardial capillary density in normal rats.
Majid Khazaei, Muhammad Amin Moshayedi, Massoud Teimouri Jervekani, Shahrzad Aghili, Saeed Montazer, Roshanak Mehdipour Dastjerdi, Fazlolah Hashemzehi, Hourossadat Hashemi Jazi   +7 more
doaj   +1 more source