Results 21 to 30 of about 1,078,448 (173)

Pulegone Prevents Hypertension through Activation of Muscarinic Receptors and Cyclooxygenase Pathway in L‐NAME‐Induced Hypertensive Rats

Cardiovascular Therapeutics, Volume 2023, Issue 1, 2023., 2023
The current study was designed to determine pulegone’s antihypertensive and vasoprotective activity in L‐NAME‐induced hypertensive rats. Firstly, the hypotensive dose‐response relationship of pulegone was evaluated in normotensive anesthetized rats using the invasive method. Secondly, the mechanism involved in hypotensive activity was determined in the
Muryam Abdul Razzaq, Waqas Younis, Muhammad Nasir Hayat Malik, Tariq G. Alsahli, Alamgeer, Shah Jahan, Roma Ehsan, Arquimedes Gasparotto Junior, Asifa Bashir, Youakim Saliba   +9 more
wiley   +1 more source

Physalis angulata Leaf Ethanol Extract Reduces Oxidative Stress and Improves Endothelial Progenitor Cells in L-NAME-Induced Hypertensive Rats

Hayati Journal of Biosciences, 2022
This study aimed to evaluate the effects of ciplukan (Physalis angulata L.) leaf ethanol extract on L-NG-nitroarginine methyl ester (L-NAME)-induced hypertensive rats. We randomly divided twenty-five Wistar rats into five groups.
Dian Nugrahenny, Nur Permatasari, Setyawati Soeharto, Indriati Dwi Rahayu, Edwin Widodo, Karyono Mintaroem, Hidayat Sujuti, Retty Ratnawati, Elly Mayangsari, Dicky Faizal Irnandi, Lavina Sofia Ardani, Tika Ardhini Wardoyo, Nathania Bella Claresta, Nura Fattah Cantika Yoga, Adinda Chika Anindita, Niarti Ulan Sari Siarnu, Fardizia Putri Alia   +16 more
doaj   +1 more source

Mineralocorticoid receptor in cardiovascular diseases—Clinical trials and mechanistic insights

British Journal of Pharmacology, Volume 179, Issue 13, Page 3119-3134, July 2022., 2022
Aldosterone binds to the mineralocorticoid receptor (NR3C2), a transcription factor of the nuclear receptor family, present in the kidney and in various other non‐epithelial cells including the heart and the vasculature. Indeed, extra‐renal pathophysiological effects of this hormone have been characterized, extending its actions to the cardiovascular ...
Johann Bauersachs, Natalia López‐Andrés   +1 more
wiley   +1 more source

Glucagon‐like peptide‐1 (GLP‐1) receptor agonists and their cardiovascular benefits—The role of the GLP‐1 receptor

British Journal of Pharmacology, Volume 179, Issue 4, Page 659-676, February 2022., 2022
Cardiovascular outcome trials revealed cardiovascular benefits for type 2 diabetes mellitus patients when treated with long‐acting glucagon‐like peptide‐1 (GLP‐1) receptor agonists. In the last decade, major advances were made characterising the physiological effects of GLP‐1 and its action on numerous targets including brain, liver, kidney, heart and ...
Johanna Helmstädter, Karin Keppeler, Leonie Küster, Thomas Münzel, Andreas Daiber, Sebastian Steven   +5 more
wiley   +1 more source

Perturbations in nitric oxide homeostasis promote Arabidopsis disease susceptibility towards Phytophthora parasitica

Molecular Plant Pathology, Volume 22, Issue 9, Page 1134-1148, September 2021., 2021
Perturbations in Arabidopsis nitric oxide homeostasis promote disease susceptibility towards the oomycete pathogen Phytophthora parasitica. Abstract Phytophthora species can infect hundreds of different plants, including many important crops, causing a number of agriculturally relevant diseases.
Beimi Cui, Xiangren Ma, Yuan Li, Yu Zhou, Xiuyun Ju, Adil Hussain, Saima Umbreen, Bo Yuan, Anika Tabassum, Jibril Lubega, Weixing Shan, Gary J. Loake, Qiaona Pan   +12 more
wiley   +1 more source

Gallic Acid Attenuates Angiotensin II-Induced Hypertension and Vascular Dysfunction by Inhibiting the Degradation of Endothelial Nitric Oxide Synthase

Frontiers in Pharmacology, 2020
Hypertension is a major cause of heart attack and stroke. Our recent study revealed that gallic acid (GA) exerts protective effects on pressure overload-induced cardiac hypertrophy and dysfunction.
Xiao Yan, Qi-Yu Zhang, Yun-Long Zhang, Xiao Han, Shu-Bin Guo, Hui-Hua Li, Hui-Hua Li   +6 more
doaj   +1 more source

Compromised Cortical-Hippocampal Network Function From Transient Hypertension: Linking Mid-Life Hypertension to Late Life Dementia Risk

Frontiers in Neuroscience, 2022
Mid-life hypertension is a major risk factor for developing dementia later in life. While anti-hypertensive drugs restore normotension, dementia risk remains above baseline suggesting that brain damage sustained during transient hypertension is ...
Aaron Y. Lai, Paolo Bazzigaluppi, Christopher D. Morrone, Mary E. Hill, Bojana Stefanovic, Bojana Stefanovic, JoAnne McLaurin, JoAnne McLaurin   +7 more
doaj   +1 more source

Performance and emissions of an agricultural diesel engine fuelled with different diesel and methyl ester blends [PDF]

, 2010
This paper shows the results of an investigation carried out to assess the application of different fuels produced by blending diesel fuel with methyl ester obtained from mixture of 75% (v/v) sunflower oil and 25% (v/v) used cooking oil on a Kubota ...
Ponce de León, M.L., Sánchez-Girón Renedo, Víctor, Ponce de Leon, J. L., Camps Michelena, Manuel, Milan, I., Sanchez-Giron, V., Camps, M.   +6 more
core   +1 more source

Short-Term Administration of Serelaxin Produces Predominantly Vascular Benefits in the Angiotensin II/L-NAME Chronic Heart Failure Model

JACC: Basic to Translational Science, 2017
Summary: In patients hospitalized with acute heart failure, temporary serelaxin infusion reduced 6-month mortality through unknown mechanisms. This study therefore explored the cardiovascular effects of temporary serelaxin administration in mice ...
Joseph C. McCarthy, MS, Mark Aronovitz, MS, Jennifer J. DuPont, PhD, Timothy D. Calamaras, PhD, Iris Z. Jaffe, MD, PhD, Robert M. Blanton, MD   +5 more
doaj   +1 more source

Maternal tadalafil therapy for fetal growth restriction prevents non-alcoholic fatty liver disease and adipocyte hypertrophy in the offspring

Scientific Reports, 2021
We aimed to investigate the effects of maternal tadalafil therapy on fetal programming of metabolic function in a mouse model of fetal growth restriction (FGR). Pregnant C57BL6 mice were divided into the control, L-NG-nitroarginine methyl ester (L-NAME),
Takuya Kawamura, Hiroaki Tanaka, Ryota Tachibana, Kento Yoshikawa, Shintaro Maki, Kuniaki Toriyabe, Hiroki Takeuchi, Shinji Katsuragi, Kayo Tanaka, Tomoaki Ikeda   +9 more
doaj   +1 more source