Results 41 to 50 of about 7,513 (165)

Overview of Antagonists Used for Determining the Mechanisms of Action Employed by Potential Vasodilators with Their Suggested Signaling Pathways [PDF]

, 2016
This paper is a review on the types of antagonists and the signaling mechanism pathways that have been used to determine the mechanisms of action employed for vasodilation by test compounds.
Ahmad, Mariam, Asmawi, Mohd Zaini, Chu, Shan Tan, Mun, Fei Yam, Yean, Chun Loh, Yung, Sing Ch’ng   +5 more
core   +1 more source

Short-Term Administration of Serelaxin Produces Predominantly Vascular Benefits in the Angiotensin II/L-NAME Chronic Heart Failure Model

JACC: Basic to Translational Science, 2017
Summary: In patients hospitalized with acute heart failure, temporary serelaxin infusion reduced 6-month mortality through unknown mechanisms. This study therefore explored the cardiovascular effects of temporary serelaxin administration in mice ...
Joseph C. McCarthy, MS, Mark Aronovitz, MS, Jennifer J. DuPont, PhD, Timothy D. Calamaras, PhD, Iris Z. Jaffe, MD, PhD, Robert M. Blanton, MD   +5 more
doaj   +1 more source

Maternal tadalafil therapy for fetal growth restriction prevents non-alcoholic fatty liver disease and adipocyte hypertrophy in the offspring

Scientific Reports, 2021
We aimed to investigate the effects of maternal tadalafil therapy on fetal programming of metabolic function in a mouse model of fetal growth restriction (FGR). Pregnant C57BL6 mice were divided into the control, L-NG-nitroarginine methyl ester (L-NAME),
Takuya Kawamura, Hiroaki Tanaka, Ryota Tachibana, Kento Yoshikawa, Shintaro Maki, Kuniaki Toriyabe, Hiroki Takeuchi, Shinji Katsuragi, Kayo Tanaka, Tomoaki Ikeda   +9 more
doaj   +1 more source

Participation of NO in the vasodilatory action of isoespintanol

Vitae, 2019
Background: accumulating evidence suggests that natural compounds and specifically monoterpenes exert a vasodilator action. Objetive: to investigate the vascular effects of isoespintanol (2-isopropil-3,6- dimetoxi-5-metilfenol, ISO) monoterpene isolated ...
Gustavo J. RINALDI, Benjamín ROJANO, Guillermo SCHINELLA, Susana M. MOSCA   +3 more
doaj   +1 more source

Tumor Necrosis Factor - Related Apoptosis-Inducing Ligand (TRAIL) promotes angiogenesis and ischemia- induced neovascularization via NADPH Oxidase 4 (NOX4) and Nitric Oxide - dependent mechanisms [PDF]

, 2015
Background — Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) has the ability to inhibit angiogenesis by inducing endothelial cell death, as well as being able to promote pro- angiogenic activity in vitro.
Azahri, N, Cartland, S, Di Bartolo, B, Gentile, C, Griffith, T, Kavurma, M, Prado-Lourenco, L, Ravindran, J, Thai, T, Thomas, S, Yeung, A   +10 more
core   +2 more sources

Reduced Brain Cortex Angiogenesis in the Offspring of the Preeclampsia-Like Syndrome

HYPERTENSION, 2023
BACKGROUND: Children from pregnancies affected by preeclampsia have an increased risk of cognitive and behavioral alterations via unknown pathophysiology.
F. Troncoso, H. Sandoval, Belén Ibáñez, D. López-Espíndola, Francisca Bustos, J. C. Tapia, Pedro Sandaña, Esthefanny Escudero-Guevara, Francisco Nualart, Eder Ramírez, Robert W Powers, Manu Vatish, H. Mistry, L. Kurlak, J. Acurio, C. Escudero   +15 more
semanticscholar   +1 more source

Leptin Enhances Nitric Oxide Production and Decreases Blood Flow in Rat Skeletal Muscle

European Journal of Biology, 2022
Objective: There are a few studies related to nitric oxide (NO) and leptin interaction in the regulation of physiological events in skeletal muscle. Therefore, the aim of the present study is to investigate the interaction of leptin and NO in response to
Savaş Üstünova, Ayşegül Kapucu, Cihan Demirci Tansel   +2 more
doaj   +1 more source

The estrogen effects on endothelial repair and mitogen-activated protein kinase activation are abolished in endothelial nitric-oxide (NO) synthase knockout mice, but not by NO synthase inhibition by N-nitro-L-arginine methyl ester. [PDF]

, 2008
We have previously shown that estrogen exerts a vasoprotective effect by accelerating reendothelialization after perivascular artery injury through activation of the estrogen receptor alpha.
Billon, Audrey, Lehoux, Stéphanie, Lam Shang Leen, Laetitia, Laurell, Henrik, Filipe, Cédric, Benouaich, Vincent, Brouchet, Laurent, Dessy, Chantal, Gourdy, Pierre, Gadeau, Alain-Pierre, Tedgui, Alain, Balligand, Jean-Luc, Arnal, Jean-François   +12 more
core   +2 more sources

S-allylcysteine Improves Blood Flow Recovery and Prevents Ischemic Injury by Augmenting Neovasculogenesis. [PDF]

, 2017
Studies suggest that a low level of circulating human endothelial progenitor cells (EPCs) is a risk factor for ischemic injury and coronary artery disease (CAD). Consumption of S-allylcysteine (SAC) is known to prevent CAD.
Chao, Che-Yi, Chiang, En-Pei Isabel, Chiu, Shao-Chih, Rodriguez, Raymond L, Syu, Jia-Ning, Tang, Feng-Yao, Tsai, Shu-Yao, Yang, Mei-Due   +7 more
core   +1 more source

Inhibition of eNOS Partially Blunts the Beneficial Effects of Nebivolol on Angiotensin II-Induced Signaling in H9c2 Cardiomyoblasts

Current Issues in Molecular Biology, 2022
We have recently illustrated that nebivolol can inhibit angiotensin II (Ang II)-mediated signaling in cardiomyoblasts; however, to date, the detailed mechanism for the beneficial effects of nebivolol has not been studied.
Rukhsana Gul, Nouf Alsalman, Assim A. Alfadda   +2 more
doaj   +1 more source