Brazilian Journal of Medical and Biological Research, 2016 A relationship between thyroid hormones and the cardiovascular system has been well established in the literature. The present in vitro study aimed to investigate the mechanisms involved in the vasodilator effect produced by the acute application of 10-8–
J. Lozano-Cuenca +6 more
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Intermedin inhibits norepinephrine-induced contraction of rat seminal vesicle
Asian Pacific Journal of Reproduction, 2014 Objective: To study the effect of inter medin(IMD) on smooth muscle of rat seminal vesicles including the specific receptors and the signal pathways involved. Methods: The contraction of the seminal vesicle in response to norepinephrine (NE) and ADM2/IMD
P.F. Wong, M.P.L. Cheung, O WS, F. Tang
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A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1) K+ channels in carbon monoxide–induced proarrhythmic early afterdepolarizations [PDF]
, 2017 Exposure to carbon monoxide (CO) causes early afterdepolarization arrhythmias. Previous studies in rats indicated arrhythmias arose due to augmentation of the late Na+ current.
Chris Peers +8 more
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Vasorelaxant mechanisms of ketamine in rabbit renal artery [PDF]
Korean Journal of Anesthesiology, 2012 BackgroundKetamine is a non-barbiturate anesthetic agent which has various effects on the cardiovascular system. Among them, ketamine is known for its hypotensive properties. The hypotension is thought to be mediated by a direct effect on vascular smooth
Il Jung, Sung Hwan Jung
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Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery. [PDF]
, 2018 Extracellular pH is an important physiological determinant of vascular tone that is normally maintained within 7.35-7.45. Any change outside this range leads to severe pathological repercussions.
Mohanty, Ipsita +3 more
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Nitric oxide regulates synaptic transmission between spiny projection neurons [PDF]
, 2014 Recurrent axon collaterals are a major means of communication between spiny projection neurons (SPNs) in the striatum and profoundly affect the function of the basal ganglia.
Greengard, Paul +9 more
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Effects of nitric oxide inhibitors in mice with bladder outlet obstruction
International Brazilian Journal of UrologyPurpose To investigate the lower urinary tract changes in mice treated with L-NAME, a non-selective competitive inhibitor of nitric oxide synthase (NOS), or aminoguanidine, a competitive inhibitor of inducible nitric oxide synthase (iNOS), after 5 weeks
Marcy Lancia Pereira +5 more
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Animals, 2020 It is assumed that nitric oxide synthase and nitric oxide are involved in the regulation of female reproduction. This study aimed to assess the roles of nitric oxide synthase (NOS) in follicular development.
Junrong Li +3 more
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Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target [PDF]
, 2018 Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed in the last years.
Abdel-Aziz +431 more
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Exploring the role of dimethylarginine dimethylaminohydrolase-mediated reduction in tissue asymmetrical dimethylarginine levels in cardio-protective mechanism of ischaemic postconditioning in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Reperfusion of ischaemic myocardium results in reduced nitric oxide (NO) biosynthesis by endothelial nitric oxide synthase (eNOS) leading to endothelial dysfunction and subsequent tissue damage. Impaired NO biosynthesis may be partly due to
Kamaldeep Kaur, Nirmal Singh, R Dhawan
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