Results 51 to 60 of about 1,078,448 (173)

Effects of Diclofenac, L-NAME, L-Arginine, and Pentadecapeptide BPC 157 on Gastrointestinal, Liver, and Brain Lesions, Failed Anastomosis, and Intestinal Adaptation Deterioration in 24 Hour-Short-Bowel Rats. [PDF]

PLoS ONE, 2016
Stable gastric pentadecapeptide BPC 157 was previously used to ameliorate wound healing following major surgery and counteract diclofenac toxicity. To resolve the increasing early risks following major massive small bowel resectioning surgery, diclofenac
Nermin Lojo, Zarko Rasic, Anita Zenko Sever, Danijela Kolenc, Darko Vukusic, Domagoj Drmic, Ivan Zoricic, Marko Sever, Sven Seiwerth, Predrag Sikiric   +9 more
doaj   +1 more source

Influence of L-Nω-nitroarginine methyl ester and sodium nitroprusside in vitro on the oxidative modification of rat lysosome proteins

, 2017
Aim. To investigate in vitro effects of 5 mM L-Nω-nitroarginine methyl ester and 0.1 mM sodium nitroprusside on oxidative modification of lysosomal proteins of liver of intact sexually mature female rats of Wistar line. Methods.
M A Fomina, S A Isakov, A N Ryabkov, A M Kudlaeva   +3 more
core   +1 more source

Nitric Oxide Synthase Is Involved in Follicular Development via the PI3K/AKT/FoxO3a Pathway in Neonatal and Immature Rats

Animals, 2020
It is assumed that nitric oxide synthase and nitric oxide are involved in the regulation of female reproduction. This study aimed to assess the roles of nitric oxide synthase (NOS) in follicular development.
Junrong Li, Wei Zhang, Shanli Zhu, Fangxiong Shi   +3 more
doaj   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Exploring the role of dimethylarginine dimethylaminohydrolase-mediated reduction in tissue asymmetrical dimethylarginine levels in cardio-protective mechanism of ischaemic postconditioning in rats [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Reperfusion of ischaemic myocardium results in reduced nitric oxide (NO) biosynthesis by endothelial nitric oxide synthase (eNOS) leading to endothelial dysfunction and subsequent tissue damage. Impaired NO biosynthesis may be partly due to
Kamaldeep Kaur, Nirmal Singh, R Dhawan
doaj   +1 more source

Functional Role of Piezo1 in Regulating Whole‐Lung Vascular Reactivity

Pulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Mechanosensitive cation channels expressed in pulmonary arterial smooth muscle (SMC) and endothelial (EC) cells contribute to the regulation of vasoconstriction and vasodilation of the pulmonary vasculature. Here, we report that activating Piezo1, a mechanosensitive cation channel, with Yoda1 induced a mild increase in pulmonary arterial ...
Sophia Parmisano, Jiyuan Chen, Yuqin Chen, Pritesh P. Jain, Lauren Yung, Wei‐Ting Wang, Ting Wang, Xiang Li, Angela Balistrieri, Sophia A. Ferrizzi, Cassia Pedron, Owen Brooks, Mona Alotaibi, Jian Wang, Joe G.N. Garcia, Patricia A. Thistlethwaite, Ayako Makino, Jason X.‐J. Yuan   +17 more
wiley   +1 more source

Addressing Key Limitations of Diastolic Function Assessment in Mouse Echocardiography by Enabling Robust Retrospective Analysis From a Standard Imaging View

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Echocardiographic assessment of diastolic function in mice remains challenging because parameters translated from clinical practice are constrained by murine physiology. In particular, parameters derived from early (E) and late (A) transmitral filling velocities are frequently compromised by wave fusion at higher heart rates.
Michael Marterstock, Antje Schauer, Alina Maslakova, Annett Opitz, Peter Dieterich, Stephan Speier, Susanne Kämmerer, Peter Mirtschink, Irakli Kopaliani, Andreas Deussen   +9 more
wiley   +1 more source

Granulocyte-Colony Stimulating Factor Increases Cerebral Blood Flow via a NO Surge Mediated by Akt/eNOS Pathway to Reduce Ischemic Injury

The Scientific World Journal, 2015
Granulocyte-colony stimulating factor (G-CSF) protects brain from ischemic/reperfusion (I/R) injury, and inhibition of nitric oxide (NO) synthases partially reduces G-CSF protection.
Hock-Kean Liew, Jon-Son Kuo, Jia-Yi Wang, Cheng-Yoong Pang   +3 more
doaj   +1 more source

Regulation of Renal Hemodynamics and Function by RGS2. [PDF]

PLoS ONE, 2015
Regulator of G protein signaling 2 (RGS2) controls G protein coupled receptor (GPCR) signaling by acting as a GTPase-activating protein for heterotrimeric G proteins. Certain Rgs2 gene mutations have been linked to human hypertension.
Patrick Osei-Owusu, Elizabeth A Owens, Li Jie, Janaina S Reis, Steven J Forrester, Tatsuo Kawai, Satoru Eguchi, Harpreet Singh, Kendall J Blumer   +8 more
doaj   +1 more source

Glutamine enhances endothelial cell survival and vasodilation by increasing glutathione to reduce oxidative stress

Physiological Reports, Volume 14, Issue 2, January 2026.
Abstract Cardiovascular disease is exacerbated by diabetes through hyperglycemia‐induced endothelial dysfunction, which arises from oxidative stress. Glutamine is postulated to decrease oxidative stress; however, its effect on endothelial dysfunction in hyperglycemia is unknown.
Marzyeh Kheradmand, Gurneet Sangha, Claire M. Sissons, Michael Sun, Xinyao Zhou, Lauren V. Smith, Meagan Bauer, Chengpeng Chen, Alisa Morss Clyne   +8 more
wiley   +1 more source